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排序方式: 共有897条查询结果,搜索用时 15 毫秒
891.
Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C 总被引:15,自引:0,他引:15
Cammà C Bruno S Di Marco V Di Bona D Rumi M Vinci M Rebucci C Cividini A Pizzolanti G Minola E Mondelli MU Colombo M Pinzello G Craxì A 《Hepatology (Baltimore, Md.)》2006,43(1):64-71
Conflicting data exist regarding the relationship between hepatitis C virus genotype 1 and hepatic steatosis as well as the latter's role in the progression of fibrosis and treatment response. We assessed factors associated with hepatic steatosis in genotype 1 chronic hepatitis C and the impact of hepatic fat on fibrosis development and interferon responsiveness. Two hundred ninety-one non-diabetic patients with genotype 1 chronic hepatitis C were examined for the presence of steatosis and its correlation with clinical, virological, and biochemical data, including insulin resistance (IR), evaluated by the homeostasis model assessment (HOMA) score. Steatosis was graded as mild (1%-20% of hepatocytes involved), moderate (21%-40% of hepatocytes involved), and severe (>40% of hepatocytes involved). Steatosis was mild in 110 of 291 (37.8%) and moderate/severe in 55 of 291 (18.9%) subjects. By logistic regression, moderate/severe steatosis was independently associated with the female sex (odds ratio [OR] 2.74; 95% CI 1.40-5.35), high gamma-glutamyltransferase levels (OR 1.52; 95% CI 1.22-1.91), and HOMA-score (OR 1.076; 95% CI 1.001-1.26). By logistic regression, moderate/severe steatosis (OR 2.78; 95% CI 1.21-6.4), and platelet counts (OR 0.97; 95% CI 0.96-0.98) were independent predictors of advanced fibrosis. Patients with moderate/severe steatosis had an OR of 0.52 (95% CI 0.30-0.90) for sustained virological response compared with patients with mild/absent steatosis. In conclusion, in nondiabetic European patients with genotype 1 hepatitis C at low risk for the metabolic syndrome, the prevalence of steatosis was nearly 60%. IR is a risk factor for moderate/severe steatosis, especially in men. Moderate/severe steatosis has clinical relevance, being associated with advanced fibrosis and hyporesponsiveness to antiviral therapy. 相似文献
892.
Federica Gobbo Claudia Zanardello Marco Bottinelli Jane Budai Francesca Bruno Roberta De Nardi Tommaso Patregnani Salvatore Catania Calogero Terregino 《Viruses》2022,14(8)
From October 2021 to January 2022, different incursions of clade 2.3.4.4b H5N1 HPAIV (Highly Pathogenic Avian Influenza Virus) occurred in several Italian regions with its main diffusion in Densely Poultry Populated Areas (DPPAs) of north-eastern Italy. Monitoring and control activities applied in the affected area clearly evidenced that turkeys and broilers were the most affected species, although several flocks of broilers at times resulted HPAIV H5N1 infected in absence of increased mortality and/or clinical signs. Thus, an approach based on sampling dead birds was adopted in the broiler sector to improve the early detection of infection; this protocol allowed us to confirm that 15 farms were HPAIV-infected with birds ready to be delivered to the slaughterhouse. The aim of this report is to describe the results of the diagnostic activities carried out in one HPAIV H5N1-infected broiler farm, three days after laboratory confirmation during the pre-movement testing without showing increased mortality or clinical signs. Thus, clinical signs, daily cumulative mortality rate (CMR), virus shedding, seroconversion, pathobiology of clade 2.3.4.4b H5N1 HPAIV as well as Avian Influenza Viruses (AIVs) environmental contamination were thoroughly examined in the infected holding. Such in-depth investigation demonstrated low infection prevalence in live birds, low environmental contamination, no seroconversion for AIVs, gross and microscopic findings compatible with systemic infection with peracute death in H5N1 HPAIV-infected birds. 相似文献
893.
Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study
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Magdalena Stepien Talita Duarte‐Salles Veronika Fedirko Anne Floegel Dinesh Kumar Barupal Sabina Rinaldi David Achaintre Nada Assi Anne Tj?nneland Kim Overvad Nadia Bastide Marie‐Christine Boutron‐Ruault Gianluca Severi Tilman Kühn Rudolf Kaaks Krasimira Aleksandrova Heiner Boeing Antonia Trichopoulou Christina Bamia Pagona Lagiou Calogero Saieva Claudia Agnoli Salvatore Panico Rosario Tumino Alessio Naccarati H. B. Bueno‐de‐Mesquita Petra H. Peeters Elisabete Weiderpass J. Ramón Quirós Antonio Agudo María‐José Sánchez Miren Dorronsoro Diana Gavrila Aurelio Barricarte Bodil Ohlsson Klas Sj?berg M?rten Werner Malin Sund Nick Wareham Kay‐Tee Khaw Ruth C. Travis Julie A. Schmidt Marc Gunter Amanda Cross Paolo Vineis Isabelle Romieu Augustin Scalbert Mazda Jenab 《International journal of cancer. Journal international du cancer》2016,138(2):348-360
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ‐p180Kit) in a case‐control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log‐transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development. 相似文献
894.
Hedwig Eisenbarth Alessandro Angrilli Antonio Calogero Jeremy Harper Lacy A. Olson Edward Bernat 《Biological psychology》2013
Studies that investigate the differences between high and low psychopathic persons in brain activity during emotional facial expression processing are rare and commonly focus on males. The current study assessed whether previously reported behavioral differences would be reflected in differential brain activity in a sample of female offenders. 相似文献
895.
Rosaria M. Pipitone Francesco Malvestiti Grazia Pennisi Oveis Jamialahmadi Paola Dongiovanni Giorgio Bertolazzi Jussi Pihlajamäki Hannele Yki-Järvinen Umberto Vespasiani-Gentilucci Federica Tavaglione Samantha Maurotti Cristiana Bianco Gabriele Di Maria Marco Enea Anna L. Fracanzani Vesa Kärjä Giulia Lupo Ville Männistö Marica Meroni Roberto Piciotti Sami Qadri Rossella Zito Antonio Craxì Vito Di Marco Calogero Cammà Claudio Tripodo Luca Valenti Stefano Romeo Salvatore Petta Stefania Grimaudo 《Liver international》2023,43(8):1761-1771
896.
897.
Antonina Luca Giulia Donzuso Giovanni Mostile Roberta Terranova Calogero Edoardo Cicero Alessandra Nicoletti Mario Zappia 《European journal of neurology》2023,30(9):2849-2853