首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3698813篇
  免费   320536篇
  国内免费   13726篇
耳鼻咽喉   50892篇
儿科学   118343篇
妇产科学   97257篇
基础医学   580724篇
口腔科学   102714篇
临床医学   331323篇
内科学   661237篇
皮肤病学   95187篇
神经病学   316886篇
特种医学   148560篇
外国民族医学   497篇
外科学   572254篇
综合类   113763篇
现状与发展   23篇
一般理论   2378篇
预防医学   309448篇
眼科学   85760篇
药学   259660篇
  22篇
中国医学   10124篇
肿瘤学   176023篇
  2021年   55044篇
  2020年   35074篇
  2019年   57990篇
  2018年   71416篇
  2017年   54456篇
  2016年   60248篇
  2015年   74234篇
  2014年   108505篇
  2013年   173587篇
  2012年   97145篇
  2011年   97541篇
  2010年   117719篇
  2009年   122052篇
  2008年   85314篇
  2007年   88613篇
  2006年   99572篇
  2005年   94681篇
  2004年   97293篇
  2003年   87756篇
  2002年   77617篇
  2001年   120831篇
  2000年   115127篇
  1999年   111699篇
  1998年   67024篇
  1997年   64584篇
  1996年   62584篇
  1995年   58197篇
  1994年   52358篇
  1993年   48897篇
  1992年   82940篇
  1991年   79401篇
  1990年   75943篇
  1989年   74615篇
  1988年   69445篇
  1987年   68137篇
  1986年   64931篇
  1985年   64809篇
  1984年   56580篇
  1983年   51284篇
  1982年   44754篇
  1981年   41914篇
  1980年   39514篇
  1979年   48960篇
  1978年   40955篇
  1977年   36773篇
  1976年   34074篇
  1975年   32839篇
  1974年   35532篇
  1973年   34195篇
  1972年   31689篇
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
91.
Introduction: Percutaneous renal mass biopsy has evolved over the last decade with improvements on previous pitfalls including low tissue yield, high non-diagnostic rates, and complications. As understanding of tumor biology and natural history of renal cortical neoplasms has improved, percutaneous renal mass biopsy is poised to have an expanding role in an area characterized by individualized management and refined risk stratification.

Areas covered: This review summarizes the evolution of renal mass biopsy to its current state with respect to outcomes, indications, and clinical guidelines.

Expert opinion: With improved understanding of differential biological potential of renal cortical neoplasms combined with technical improvements in diagnostic yield and accuracy, utilization of renal mass biopsy is becoming an important adjunct to patient care in a broad range of clinical scenarios, including active surveillance, thermal ablation, and use of primary systemic therapy in localized and advanced settings.  相似文献   

92.
93.
94.
95.
96.
MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer‐enriched miRNA is required for prostate tumorigenesis. We identify miR‐205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR‐205 is not required for normal prostate development and homeostasis, genetic deletion of miR‐205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR‐205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR‐205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR‐205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR‐205 in the progression of Pten null‐induced prostate cancer.  相似文献   
97.
98.
Secondary tricuspid regurgitation (TR) caused by right ventricular enlargement in the setting of left heart disease/pulmonary hypertension has been well described. In contrast, that associated with right atrial enlargement—atrial functional TR (AF‐TR)—remains largely underappreciated. AF‐TR most often occurs in the setting of lone atrial fibrillation, although it is also seen in its absence (idiopathic AF‐TR). Several recent studies have found that the prevalence, hemodynamic significance, and prognosis of AF‐TR are not inconsequential, suggesting increased physician awareness of this novel clinical entity is warranted. This article discusses the pathogenesis, echocardiographic findings, and treatment of this underappreciated cause of secondary TR.  相似文献   
99.
We review the spectrum of cutaneous disorders associated with inflammatory and neoplastic plasmacytic pathology. Because plasma cells are derived from B‐lymphocytes our overview includes discussion of certain lymphoplasmacytic proliferations. It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous plasma cell infiltrates, (b) deposits of plasma cell products or their derivatives in the skin and (c) miscellaneous, poorly understood cutaneous complications of plasmacytic disorders. Lesions arising primarily in the skin and those due to cutaneous involvement by multisystem disorders are addressed. The range includes a spectrum of tumefactive and circulatory manifestations. We highlight key clinical and pathological features of the different conditions and outline recent advances in our understanding of these entities. By emphasizing the dermatopathological characteristics of this spectrum of disorders we hope to hone the diagnostic accuracy of practitioners in the field.  相似文献   
100.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号