全文获取类型
收费全文 | 265篇 |
免费 | 20篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 18篇 |
妇产科学 | 12篇 |
基础医学 | 24篇 |
口腔科学 | 12篇 |
临床医学 | 38篇 |
内科学 | 44篇 |
皮肤病学 | 9篇 |
神经病学 | 23篇 |
特种医学 | 4篇 |
外科学 | 28篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 27篇 |
眼科学 | 10篇 |
药学 | 20篇 |
中国医学 | 2篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 8篇 |
2022年 | 17篇 |
2021年 | 27篇 |
2020年 | 13篇 |
2019年 | 19篇 |
2018年 | 23篇 |
2017年 | 18篇 |
2016年 | 17篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 22篇 |
2012年 | 17篇 |
2011年 | 25篇 |
2010年 | 17篇 |
2009年 | 6篇 |
2008年 | 9篇 |
2007年 | 9篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2002年 | 2篇 |
排序方式: 共有285条查询结果,搜索用时 15 毫秒
41.
42.
Eskin Mehmet AlBuhairan Fadia Rezaeian Mohsen Abdel-Khalek Ahmed M. Harlak Hacer El-Nayal Mayssah Asad Nargis Khan Aqeel Mechri Anwar Noor Isa Multazam Hamdan Motasem Isayeva Ulker Khader Yousef Al Sayyari Alaa Khader Albaraa Behzadi Bahareh Öztürk Cennet Şafak Hendarmin Laifa Annisa Khan Murad Moosa Khatib Salam 《The Psychiatric quarterly》2019,90(1):229-248
Psychiatric Quarterly - There is a scarcity of research on suicidal phenomena in the Muslim world. Therefore, this study aimed at investigating the self-reported prevalence of suicidal thoughts,... 相似文献
43.
Mohebi Nafiseh Arab Mahsa Moghaddasi Mehdi Behnam Ghader Bahareh Emamikhah Maziar 《Journal of neurology》2019,266(10):2584-2586
Journal of Neurology - Supplementary motor area, the posterior third of the medial aspect of superior frontal gyrus, is known to be a heterogeneous area in function. It is involved in... 相似文献
44.
Expression of miR-9 and miR-200c,ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran 下载免费PDF全文
45.
Shahram Majidi Yamane Makke Amr Ewida Bahareh Sianati Adnan I. Qureshi Mohamad Z. Koubeissi 《Neurocritical care》2017,27(1):90-95
Background
Traumatic brain injury (TBI) is a well-known risk factor for seizures. We aimed to identify the frequency and risk factors for seizure occurrence during hospitalization for TBI.Methods
We used ICD-9-CM codes to identify patients 18 years of age or older from the National Trauma Data Bank who were admitted with TBI. We also used ICD-9-CM codes to identify the subset who had seizures during hospitalization. Patient demographics, comorbidities, Glasgow Coma Scale (GCS) score, Injury Severity Score Abbreviated Injury Scale (ISSAIS), in-hospital complications, and discharge disposition were compared in the seizure group (SG) and no-seizure group (NSG).Results
A total of 1559 patients had in-hospital seizures, comprising 0.4% of all patients admitted with TBI. The mean age of SG was 3 years older than NSG [51 vs. 48; p < 0.0001]. African-American ethnicity (20 vs. 12%, p < 0.0001) and moderate TBI (8 vs. 4%, p < 0.0001) were more common in SG. History of alcohol dependence was more common in the SG (25 vs. 11%, p < 0.0001). Fall was the most common mechanism of injury in SG (56 vs. 36% in NSG; p < 0.0001). Subdural hematoma was more common in SG (31 vs. 21%, p < 0.0001). SG had higher rates of pneumonia, ARDS, acute kidney injury, and increased ICP. The average length of hospital stay was significantly higher in SG (10 vs. 6 days, p < 0.0001), and these patients had higher rate of discharge to nursing facility (32 vs. 25%, p < 0.0001).Conclusion
In-hospital seizures occur in 0.4% of all TBI patients. Although infrequent, seizure occurrence is associated with higher rates of hospital complications such as pneumonia and ARDS and is an independent predictor of longer hospital stay and worse hospital outcome.46.
Justus C. Dchsel Bahareh Behrouz Mei Yue Joel E. Beevers Heather L. Melrose Matthew J. Farrer 《Parkinsonism & related disorders》2010,16(10):650-655
ObjectiveTo assess the contribution of wild-type, mutant and loss of leucine-rich repeat kinase-2 (LRRK2; Lrrk2) on dendritic neuronal arborization.BackgroundLRRK2 mutations are recognized as the major genetic determinant of susceptibility to Parkinson’s disease for which a cellular assay of Lrrk2 mutant function would facilitate the development of targeted molecular therapeutics.MethodsDendritic neuronal arborization (neurite length, branching and the number of processes per cell) was quantified in primary hippocampal and midbrain cultures derived from five lines of recombinant LRRK2 mice, including human BAC wild-type and mutant overexpressors (Y1699C and G2019S), murine knock-out and G2019S knock-in animals.ResultsNeuronal arborization in cultures from BAC Lrrk2 wild-type animals is comparable to non-transgenic littermate controls, despite high levels of human transgene expression. In contrast, primary neurons from both BAC mutant overexpressors presented with significantly reduced neuritic outgrowth and branching, although the total number of processes per cell remained comparable. The mutant-specific toxic gain-of-function observed in cultures from BAC mutant mice may be partially rescued by staurosporine treatment, a non-specific kinase inhibitor. In contrast, neuronal arborization is far more extensive in neuronal cultures derived from murine knock-out mice that lack endogenous Lrrk2 expression. In Lrrk2 G2019S knock-in mice, arguably the most physiologically relevant system, neuritic arborization is not impaired.ConclusionsImpairment of neuritic arborization is an exaggerated, albeit mutant specific, consequence of Lrrk2 over-expression in primary cultures. The phenotype and assay described provides a means to develop therapeutic agents that modulate the toxic gain-of-function conferred by mutant Lrrk2. 相似文献
47.
Carles Vilariño-Güell Christian Wider Owen A. Ross Barbara Jasinska-Myga Jennifer Kachergus Stephanie A. Cobb Alexandra I. Soto-Ortolaza Bahareh Behrouz Michael G. Heckman Nancy N. Diehl Claudia M. Testa Zbigniew K. Wszolek Ryan J. Uitti Joseph Jankovic Elan D. Louis Lorraine N. Clark Alex Rajput Matthew J. Farrer 《Neurogenetics》2010,11(4):401-408
Genetic variation in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was recently associated with an increased risk of developing essential tremor (ET) and Parkinson disease (PD). Herein, we performed a comprehensive study of LINGO1 and its paralog LINGO2 in ET and PD by sequencing both genes in patients (ET, n?=?95; PD, n?=?96) and by examining haplotype-tagging single-nucleotide polymorphisms (tSNPs) in a multicenter North American series of patients (ET, n?=?1,247; PD, n?=?633) and controls (n?=?642). The sequencing study identified six novel coding variants in LINGO1 (p.S4C, p.V107M, p.A277T, p.R423R, p.G537A, p.D610D) and three in LINGO2 (p.D135D, p.P217P, p.V565V), however segregation analysis did not support pathogenicity. The association study employed 16 tSNPs at the LINGO1 locus and 21 at the LINGO2 locus. One variant in LINGO1 (rs9652490) displayed evidence of an association with ET (odds ratio (OR)?=?0.63; P?=?0.026) and PD (OR?=?0.54; P?=?0.016). Additionally, four other tSNPs in LINGO1 and one in LINGO2 were associated with ET and one tSNP in LINGO2 associated with PD (P?<?0.05). Further analysis identified one tSNP in LINGO1 and two in LINGO2 which influenced age at onset of ET and two tSNPs in LINGO1 which altered age at onset of PD (P?<?0.05). Our results support a role for LINGO1 and LINGO2 in determining risk for and perhaps age at onset of ET and PD. Further studies are warranted to confirm these findings and to determine the pathogenic mechanisms involved. 相似文献
48.
Behrouz B Vilariño-Güell C Heckman MG Soto-Ortolaza AI Aasly JO Sando S Lynch T Craig D Uitti RJ Wszolek ZK Ross OA Farrer MJ 《Neuroscience letters》2010,486(3):228-230
Mitochondrial dysfunction has been proposed to play a role in the pathogenesis of Parkinson's disease (PD). Supportive of this hypothesis, several genetic variants that regulate mitochondrial function and homeostasis have been described to alter PD susceptibility. A recent report demonstrated association of a single nucleotide polymorphism in the mitochondrial translation initiation factor 3 (MTIF3) gene with PD risk. The protein encoded by this nuclear gene is essential for initiation complex formation on the mitochondrial 55S ribosome and regulates translation of proteins within the mitochondria. Changes in the function or expression of the MTIF3 protein may result in altered mitochondrial function, ATP production or formation of reactive oxygen species thereby affecting susceptibility to PD. We examined the association of rs7669 with sporadic PD in three Caucasian case control series (n=2434). A significant association was observed in the largest series (Norwegian; n=1650) when comparing CC vs. CT/TT genotypes, with the Irish and US series having a similar but non-significant trend. The combined series also revealed an association with risk of PD (P=0.01), supporting the possible involvement of this gene in PD etiology. 相似文献
49.
Bahareh Amirkalali Farshad Sharifi Hossein Fakhrzadeh Mojde Mirarefein Maryam Ghaderpanahi Zohreh Badamchizadeh Bagher Larijani 《Nutrition Research》2010
Anthropometric and classical biologic markers of malnutrition, such as serum albumin, are limited because they are influenced by nonnutritional factors. We propose that a biologic parameter that both predicts nutritional status and is unaffected by nonnutritional factors would facilitate the diagnosis of malnutrition in the elderly. This cross-sectional study included 179 randomized elderly patients. Nutritional status was assessed by the Mini-Nutritional Assessment (MNA) instrument; other end points included anthropometric measures and biologic parameters. Subjects were divided into 3 groups based on MNA-defined nutritional status, and end point means were compared using 2-way analyses of variance adjusted by sex. Correlations between the most accurate biologic marker in predicting malnutrition and other biologic and clinical variables were assessed using Pearson correlation test. Multiple linear regressions were then performed to relate the best biomarker of malnutrition to specific parameters. Finally, leptin levels that predict malnutrition were determined using receiver operating characteristic curve cutoff values. The well-nourished group had significantly higher leptin (P = .001), weight, body mass index, mid-arm circumference, and calf circumference (all, P < .001) compared with the malnourished group and the at risk of malnutrition group. Serum leptin was the optimal biomarker of MNA-defined malnutrition and had significant positive correlations with weight (P = .003) and with all anthropometric values (all P < .001), but no significant correlation with C-reactive protein. Sex, weight, and triglyceride were the best predictors of serum leptin (all P < .001). The optimal cutoff value of serum leptin to detect malnutrition was 4.3 ng/mL in men and 25.7 ng/mL in women. Serum leptin may be a good predictor of nutritional status in elderly patients. 相似文献
50.