ABSTRACTBackground: Addiction has been reported as a major personal, social and political challenge in people of different strata and education levels in all countries. The present study was conducted to predict addiction potential based on sensation-seeking, psychological hardiness and assertiveness in students. Methods: The present correlational study was conducted in 2018 on a statistical population comprising all the students of the School of Medicine in Kermanshah University of Medical Sciences, Kermanshah, Iran. Convenience sampling was used to select 200 subjects. The data collection tools included the sensation-seeking scale, the psychological hardiness questionnaire, the assertion inventory and the addiction potential scale. The data collected were analyzed in SPSS using the statistical methods of the Pearson correlation coefficient and regression analysis. Results: Analyzing the findings showed the total scores of addiction potential and active addiction potential are positively associated with the total score of sensation-seeking and negatively and significantly correlated with that of psychological hardiness. Conclusions: Given the role of sensation-seeking, psychological hardiness and assertiveness in addiction potential, university authorities are recommended to hold workshops and seminars to enhance the awareness of students of the personality traits conducive to addiction. 相似文献
Fish skin grafting as a new skin substitute is currently being used in clinical applications. Acceleration of the wound healing, lack of disease transmission, and low cost of the production process can introduce fish skin as a potential alternative to other grafts. An appropriate decellularization process allows the design of 3D acellular scaffolds for skin regeneration without damaging the morphology and extracellular matrix content. Therefore, the role of decellularization processes is very important to maintain the properties of fish skin. In this review article, recent studies on various decellularization processes as well as biological, physical, and mechanical properties of fish skin and its applications with therapeutic effects in wound healing were investigated. 相似文献
Purpose: The aim of the study was to evaluate the effect of limited dissection of Tenon capsule on the outcome of strabismus surgery.
Methods: Patients between the ages of 2 and 50 years with pure horizontal strabismus were enrolled in a prospective study. Patients were divided into two groups: case and control as a non-randomized study. The method of operation was similar in both groups except for the amount of sheath Tenon dissection. In the control group the intermuscular connections and Tenon capsule were cut as much as possible. In the study group, Tenon capsule, 3-4 mm posterior to the location of the sutures over the muscle (recessed or resected), were cut and intermuscular connections remained intact.
Results: The study enrolled 54 patients with 27 patients in each group. In both groups, after operation, regardless of the type of surgery, the angle of strabismus was reduced (P< 0.05). For patients who had undergone bimedial recession, the angle of strabismus was corrected to 2.6 ± 0.4 prism diopters per mm (PD/mm) of muscle recession in the case group, and 2.2 ± 0.9 in the control group (P=0.2). For patients who had undergone monocular recession and resection (R&R) for esotropia, the angle of strabismus was corrected 3.4 ± 0.3 PD/mm of muscle recession or resection in the case group, and 3.2 ± 0.2 in the control group (P=0.05). For patients who had undergone bilateral recession, the angle of strabismus was corrected 2.3 ± 0.2 PD/mm of muscle recession in the case group, and 2.2±0.2 in the control group (P=0.03). For patients who had undergone R&R for exotropia, the angle of strabismus was corrected 3.1 ± 0.5 PD/mm of muscle recession or resection in the case group, and 2.7 ± 0.3 in the control group (P=0.02).
Conclusion: Connective tissue ensheathments, whether disturbed or removed, do not ultimately affect the success of the strabismus surgery. 相似文献
Remarkable findings from genome-wide association studies (GWAS) on blood pressure (BP) traits have made new insights for developing precision medicine toward more effective screening measures. However, generality of GWAS findings in diverse populations is hampered by some technical limitations. There is no comprehensive study to evaluate source(s) of the non-generality of GWAS results on BP traits, so to fill the gap, this systematic review study was carried out. Using MeSH terms, 1545 records were detected through searching in five databases and 49 relevant full-text articles were included in our review. Overall, 749 unique variants were reported, of those, majority of variants have been detected in Europeans and were associated to systolic and diastolic BP traits. Frequency of genetic variants with same position was low in European and non-European populations (n = 38). However, more than 200 (>25%) single nucleotide polymorphisms were found on same loci or linkage disequilibrium blocks (r2 ≥ 80%). Investigating for locus position and linkage disequilibrium of infrequent unique variants showed modest to high reproducibility of findings in Europeans that in some extent was generalizable in other populations. Beyond theoretical limitations, our study addressed other possible sources of non-generality of GWAS findings for BP traits in the same and different origins. 相似文献
The purpose of this in vitro study was to evaluate quantitatively the effectiveness of three different restorative materials used as an intracoronal barrier to prevent microleakage of endodontically treated teeth. Fifty-five extracted human single-canal teeth were used in this study. The teeth were endodontically prepared and obturated. Forty-five teeth were randomly assigned to three experimental groups: group 1: sealed with Ketac-Cem (3M ESPE, St Paul, MN) (n = 15), group 2: sealed with Clearfil Protect Bond/Clearfil AP-X (Kuraray, New York, NY) (n = 15), and group 3: sealed with Maxcem (Kerr, Orange, CA) (n = 15). Ten teeth were also randomly assigned to a negative control group (n = 5) and a positive control group (n = 5). Microleakage was tested by using a sterile two-chamber bacterial method and Enterococcus faecalis was used as a microbial marker. Samples were incubated aerobically at 37 degrees C for 120 days. Bacterial leakage was determined by change in turbidity in the medium. Statistical analysis was performed using a Wald chi-square test. No significant difference (p > 0.05) in bacterial leakage was found between the three experimental groups tested. All positive controls leaked within 60 days and broth of the negative control group remained clear throughout the entire experimental period. 相似文献
In recent years, tissue regeneration has become a promising field for developing stem cell-based transplantation therapies for human patients. Adult stem cells are affected by the same aging mechanisms that involve somatic cells. One of the mechanisms involved in cellular aging is hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and disruption of 5′ adenosine monophosphate-activated protein kinase (AMPK). Aging of stem cells results in their impaired regenerative capacity and depletion of stem cell pools in adult tissue, which results in lower efficacy of stem cell therapy. By utilizing an effective therapeutic intervention for aged stem cells, stem cell therapy can become more promising for future application. mTORC1 inhibition is a practical approach to preserve the stem cell pool. In this article, we review the dynamic interaction between sirtuin (silent mating type information regulation 2 homolog) 1, AMPK, and mTORC1. We propose that using AMPK activators such as 5-aminoimidazole-4-carboxamide ribonucleotide, A769662, metformin, and oxidized nicotinamide adenine dinucleotide (NAD+) are practical ways to be employed for achieving better optimized results in stem cell-based transplantation therapies. 相似文献
Journal of Neurology - Bilateral medial vestibular nuclei (MVN) is a common target in thiamine depletion and results in acute vestibular failure. Involvement of the MVN was present in 27 out of 38... 相似文献