全文获取类型
收费全文 | 7013篇 |
免费 | 345篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 153篇 |
儿科学 | 326篇 |
妇产科学 | 138篇 |
基础医学 | 630篇 |
口腔科学 | 226篇 |
临床医学 | 448篇 |
内科学 | 1481篇 |
皮肤病学 | 104篇 |
神经病学 | 401篇 |
特种医学 | 243篇 |
外科学 | 1534篇 |
综合类 | 91篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 242篇 |
眼科学 | 134篇 |
药学 | 573篇 |
中国医学 | 29篇 |
肿瘤学 | 628篇 |
出版年
2023年 | 31篇 |
2022年 | 72篇 |
2021年 | 205篇 |
2020年 | 87篇 |
2019年 | 141篇 |
2018年 | 189篇 |
2017年 | 140篇 |
2016年 | 172篇 |
2015年 | 226篇 |
2014年 | 326篇 |
2013年 | 370篇 |
2012年 | 586篇 |
2011年 | 639篇 |
2010年 | 378篇 |
2009年 | 328篇 |
2008年 | 466篇 |
2007年 | 490篇 |
2006年 | 462篇 |
2005年 | 451篇 |
2004年 | 402篇 |
2003年 | 358篇 |
2002年 | 331篇 |
2001年 | 67篇 |
2000年 | 44篇 |
1999年 | 36篇 |
1998年 | 47篇 |
1997年 | 43篇 |
1996年 | 31篇 |
1995年 | 26篇 |
1994年 | 34篇 |
1993年 | 30篇 |
1992年 | 17篇 |
1991年 | 31篇 |
1990年 | 20篇 |
1989年 | 17篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 9篇 |
1981年 | 12篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1970年 | 2篇 |
1931年 | 1篇 |
排序方式: 共有7387条查询结果,搜索用时 109 毫秒
61.
Kindling has been suggested as a possible mechanism for cocaine-induced seizures in chronic cocaine abusers, even though no convincing examples have been reported. We report a 37-year-old woman who initially experienced generalized tonic-clonic seizures (GTC) only immediately after "crack" use. She had a normal examination, negative family or past history for seizures, and normal cranial computed tomography and EEG. After she had abused cocaine almost daily for 2 years, her EEG demonstrated bitemporal slowing with independent spikes, and seizures were no longer temporally associated with acute cocaine use. Thereafter, despite complete abstinence from cocaine and treatment with phenytoin, she continued to experience four to six GTC a month. In light of the lack of other predisposing factors for epilepsy, this case may represent an example of cocaine-induced kindling in humans. 相似文献
62.
Increased expression and secretion of interleukin-6 in patients with Barrett's esophagus. 总被引:6,自引:0,他引:6
63.
Sanjeev C Joshi Daya N Sharma Anil K Bahadur Rajesh Maurya Sanjeev Kumar Nita Khurana 《Journal of Medical Imaging and Radiation Oncology》2003,47(4):434-437
Twenty‐six patients of Cystosarcoma phyllodes, treated between July 1994 and July 2001, were analysed retrospectively. Median age at presentation was 38 years (range 13?61 years). Mean size of the lesion was 6 cm. There were 77% left‐sided lesions and 23% right‐sided lesions. Histologically, 58% lesions were benign, 11% borderline and 31% malignant lesions. All patients underwent definitive surgical procedure in the form of wide local excision or mastectomy. Four patients received postoperative radiotherapy. Median follow‐up period was 35 months. Six patients showed recurrence, and four of these were malignant. Median disease‐free survival period was 34 months. 相似文献
64.
Renee D. Goodwin Kate Hottinger Lillian Pena Anil Chacko Jonathan Feldman Marianne Z. Wamboldt 《The Journal of asthma》2014,51(6):639-644
Objective: To investigate the prevalence of asthma and mental health problems among representative samples of youth in high-risk service settings and the community, and to examine the relationship between asthma and mental health in these groups. Methods: Data were drawn from the Alternative Service Use Patterns of Youth with Serious Emotional Disturbance Study (SED) (n?=?1181), a combined representative, cross-sectional sample of youth in various clinical settings and the community. Multiple logistic regression analyses were used to examine the association between asthma and mental disorders. Demographic characteristics were investigated as potential confounders. Results: Asthma was common among 15.2% of youth in service settings and 18.8% of youth in the community. The prevalence of mental disorders was extremely high among youth with and without asthma in all service settings, and asthma was associated with increased prevalence of mental disorders among youth in the community, but not among youth in service settings. The relationship between asthma and internalizing disorders among youth in the community does not appear entirely attributable to confounding by demographics. Conclusions: Findings are consistent with and extend previous data by showing that both asthma and mental disorders are disproportionately common among youth in high-risk service settings. Almost half of youth with asthma in service settings meet diagnostic criteria for a mental disorder. Clinicians and policy makers who are responsible for the health care of youth in these high-risk groups should be aware that asthma is common, and that the prevalence of internalizing disorders are especially common among those with asthma. 相似文献
65.
66.
67.
68.
Rice JP Hartz SM Agrawal A Almasy L Bennett S Breslau N Bucholz KK Doheny KF Edenberg HJ Goate AM Hesselbrock V Howells WB Johnson EO Kramer J Krueger RF Kuperman S Laurie C Manolio TA Neuman RJ Nurnberger JI Porjesz B Pugh E Ramos EM Saccone N Saccone S Schuckit M Bierut LJ;the GENEVA Consortium 《Addiction (Abingdon, England)》2012,107(11):2019-2028
AIMS: Nicotine dependence is a highly heritable disorder associated with severe medical morbidity and mortality. Recent meta-analyses have found novel genetic loci associated with cigarettes per day (CPD), a proxy for nicotine dependence. The aim of this paper is to evaluate the importance of phenotype definition (i.e. CPD versus Fagerstr?m Test for Cigarette Dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence. DESIGN: Genome-wide association study. SETTING: Community sample. PARTICIPANTS: A total of 3365 subjects who had smoked at least one cigarette were selected from the Study of Addiction: Genetics and Environment (SAGE). Of the participants, 2267 were European Americans, 999 were African Americans. MEASUREMENTS: Nicotine dependence defined by FTCD score ≥4, CPD. FINDINGS: The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR)?=?0.65, P?=?2.4?×?10(-8) ]. This association was further strengthened in a meta-analysis with a previously published data set (combined P?=?6.7?×?10(-16) , total n?=?4200). When CPD was used as an alternate phenotype, the association no longer reached genome-wide significance (β?=?-0.08, P?=?0.0004). CONCLUSIONS: Daily cigarette consumption and the Fagerstrom Test for Cigarette Dependence show different associations with polymorphisms in genetic loci. 相似文献
69.
Anil K Jain 《Indian Journal of Orthopaedics》2013,47(3):322-Jun;47(3):322
70.
Rimesh Pal Naresh Sachdeva Soham Mukherjee Vikas Suri Deepy Zohmangaihi Sant Ram Goverdhan Dutt Puri Ashish Bhalla Shiv Lal Soni Navin Pandey Anil Bhansali Sanjay Kumar Bhadada 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):193-196
Background and aimsPatients with diabetes mellitus (DM) often demonstrate impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM).MethodsRecords of non-severe COVID-19 patients admitted at our institution between April 10, 2020 and May 20, 2020 were retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (PCR) confirmation of diagnosis.ResultsThirty-one non-severe COVID-19 patients were included. Nine patients (29%) had T2DM with mean HbA1c at admission of 8.3 ± 1.0%. Anti-SARS-CoV-2 antibody was estimated at a median of 16 (14–17) days post-PCR confirmation of COVID-19 diagnosis. Only three patients (10%) were seronegative, and all had T2DM. Patients with T2DM were more likely to have non-detectable anti-SARS-CoV-2 antibodies than those without DM (p = 0.019).ConclusionsCOVID-19 patients with T2DM may not undergo seroconversion even after two weeks of diagnosis. Impaired seroconversion could theoretically increase the risk of reinfections in patients with DM. However, the finding requires validation in large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in patients with and without DM. 相似文献