全文获取类型
收费全文 | 158篇 |
免费 | 10篇 |
国内免费 | 5篇 |
专业分类
儿科学 | 5篇 |
基础医学 | 46篇 |
口腔科学 | 1篇 |
临床医学 | 14篇 |
内科学 | 49篇 |
皮肤病学 | 6篇 |
特种医学 | 2篇 |
外科学 | 8篇 |
综合类 | 2篇 |
预防医学 | 22篇 |
眼科学 | 13篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 7篇 |
2015年 | 4篇 |
2014年 | 4篇 |
2013年 | 4篇 |
2012年 | 9篇 |
2011年 | 12篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 20篇 |
2007年 | 17篇 |
2006年 | 26篇 |
2005年 | 9篇 |
2004年 | 11篇 |
2003年 | 9篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1986年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有173条查询结果,搜索用时 15 毫秒
81.
Prapai Dejkhamron Jeerunda Santiprabhob Supawadee Likitmaskul Chaicharn Deerochanawong Petch Rawdaree Thipaporn Tharavanij Sirimon Reutrakul Chawkaew Kongkanka Chittiwat Suprasongsin Nawaporn Numbenjapon Taninee Sahakitrungruang Raweewan Lertwattanarak Pontipa Engkakul Apiradee Sriwijitkamol Manassawee Korwutthikulrangsri Rattana Leelawattana Mattabhorn Phimphilai Somkiat Potisat Panthep Khananuraksa Cherdchai Nopmaneejumruslers Wannee Nitiyanant the Thai Type Diabetes Diabetes Diagnosed Before Age Years Registry Care Network 《Journal of diabetes investigation.》2021,12(4):516-526
Aims/IntroductionThe Thai Type 1 Diabetes and Diabetes Diagnosed Before Age 30 Years Registry, Care and Network was established in 2014 and involved 31 hospitals. The objective of the registry was to evaluate glycemic control and complications of patients with type 1 diabetes.Materials and MethodsPatients’ demographics, clinical data, frequencies of daily self‐monitoring of blood glucose (SMBG), glycemic control and complications were collected.ResultsAmong the 1,907 type 1 diabetes patients, the mean age was 21.2 ± 11.3 years. The mean glycated hemoglobin level was 9.35 ± 2.41%, with significant variations among age groups (P < 0.001). Conventional insulin treatment and intensive insulin treatment were used in 43 and 57% of patients, respectively. Mean glycated hemoglobin levels were significantly higher in patients treated with conventional insulin treatment compared to those treated with intensive insulin treatment (9.63 ± 2.34 vs 9.17 ± 2.46%, P = 0.002). Compared to the conventional insulin treatment group, significantly more patients in the intensive insulin treatment group achieved good glycemic control (P < 0.001), and fewer had diabetic retinopathy (P = 0.031). The prevalence of microvascular complications increased significantly with age (P < 0.001). Multivariate analysis showed good glycemic control to be associated with age 25 to <45 years, intensive insulin treatment with SMBG three or more times daily and diabetes duration of 1 to <5 years.ConclusionsMost Thai type 1 diabetes patients were not meeting the recommended glycemic target. As a result of this study, the national program to improve the quality of diabetes treatment and education has been implemented, and the results are ongoing. 相似文献
82.
Clinical significance of p53 antigen and anti-p53 antibodies in the sera of hepatocellular carcinoma patients 总被引:6,自引:0,他引:6
Navapun Charuruks Pisit Tangkijvanich Narin Voravud Ratana Chatsantikul Apiradee Theamboonlers Yong Poovorawan 《Journal of gastroenterology》2001,36(12):830-836
Background. To analyze the clinical significance of serum p53 protein and anti-p53 antibodies as serological markers for hepatocellular
carcinoma (HCC). Methods. We studied clinical data, i.e., age, sex, etiology, serum alpha-fetoprotein (AFP) level, TMN staging, and Okuda staging in
141 patients with HCC. The sera of these patients were analyzed for serum p53 protein and serum anti-p53 antibodies by enzyme-linked
immunosorbent assay (ELISA). Results. Serum p53 antigen and serum anti-p53 antibodies were detected in the sera of 32 of the 141 (22.7%) patients and 26 of the
141 patients (18.4%), respectively. Of note, the HCC patients who were positive for p53 antigen (32/141) had no circulating
anti-p53 antibodies. When both these groups of patients were combined as a serum p53 status-positive group, the total number
in this group was 58 (41.1%). Positive status of p53 was not associated with age (P = 0.206), serum alpha-fetoprotein level (P = 0.851), Okuda staging (P = 0.243), or survival (P = 0.078), but was correlated significantly with TMN staging (P = 0.049). Interestingly, a shorter survival time (mean, 3.9 months) was noted in the serum p53 status-positive group, in
comparison with the longer survival time (mean, 6.5 months) in the serum p53 status-negative group. Conclusions. Combination of the detection of serum p53 antigen and antibodies by ELISA may represent a suitable noninvasive investigation
in assessing the clinical implications and prognoses of patients with HCC.
Received: December 8, 2000 / Accepted: June 22, 2001 相似文献
83.
Elevated serum nitric oxide metabolites in biliary atresia 总被引:1,自引:0,他引:1
Vejchapipat P Chongsrisawat V Theamboonlers A Chittmittrapap S Poovorawan Y 《Pediatric surgery international》2006,22(1):106-109
Biliary atresia (BA) remains one of the most intractable liver diseases in children. The aim of this study was to investigate
the possible roles of nitric oxide (NO) in BA. Serum levels of nitrite and nitrate (NO production) were determined using a
colorimetric method from 65 post-operative BA patients and 12 healthy children. The patients were categorized into two groups
according to their jaundice status, and serum alanine aminotransferase (ALT, a marker for liver injury). Unpaired t tests were used. Data are expressed as mean and SD in terms of μmol/l. Age and gender between BA patients and controls were
comparable. Serum NO metabolites of BA patients was higher than the controls (79.77±21.22 vs. 65.75±9.44, P=0.001). Subgroup analysis revealed that there was no difference in serum nitrate/nitrite levels of BA patients without jaundice
compared to those with jaundice (78.85±23.23 vs. 80.90±18.76, P=0.70). However, patients with serum ALT≥100 IU/l had higher levels of serum NO metabolites compared to those with serum ALT<100 IU/l.
In conclusion, NO production was elevated in BA patients compared to normal controls. Serum NO was associated with serum ALT
levels, but not with jaundice status, in BA patients. These suggest that NO plays a role in the pathophysiology of liver injury
in post-operative BA. 相似文献
84.
85.
86.
Pattaratida Sa‐nguanmoo Pisit Tangkijvanich Nutchanart Thawornsuk Preeyaporn Vichaiwattana Kesmanee Prianantathavorn Apiradee Theamboonlers Yasuhito Tanaka Yong Poovorawan 《Journal of medical virology》2010,82(8):1341-1349
Although hepatitis B virus (HBV) infection is endemic in Southeast Asia, molecular epidemiological data on HBV circulating in some countries are limited. The aims of this study were to evaluate the seroprevalence of HBV and its genetic variability among migrant workers from Cambodia, Laos, and Myanmar in Thailand. Sera collected from 1,119 Cambodian, 787 Laotian, and 1,103 Myanmarese workers were tested for HBsAg. HBV DNA was amplified and the pre‐S/S region was sequenced for genotyping and genetic mutation analysis. HBsAg was detected in 282 (9.4%). The prevalence of HBsAg among migrant workers from Cambodia, Laos, and Myanmar was 10.8%, 6.9%, and 9.7%, respectively. Of 224 subjects positive for HBV DNA, 86% were classified as genotype C (99% were sub‐genotype C1) and 11.6% were genotype B (30.8%, 34.6%, and 30.8% were sub‐genotypes B2, B3, and B4, respectively). Various point mutations in the “a” determinant region were detected in approximately 18% of these samples, of which Ile126Ser/Asn was the most frequent variant. Sequencing analysis showed that 19.1% of samples had pre‐S mutations, with pre‐S2 deletion as the most common mutant (7.7%) followed by pre‐S2 start codon mutation (3.8%) and both pre‐S2 deletion and start codon mutation (3.3%). High prevalence of HBV infection (approximately 7–11%) was found among migrant workers from Cambodia, Laos, and Myanmar, which may reflect the current seroprevalence in their respective countries. The data also demonstrated that HBV sub‐genotype C1 was the predominant strain and various mutations of HBV occurring naturally were not uncommon among these populations. J. Med. Virol. 82:1341–1349, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
87.
Juthatip Keawcharoen Thanunrat Thongmee Raphee Panyathong Pichai Joiphaeng Supansa Tuanthap Kanisak Oraveerakul Apiradee Theamboonlers Yong Poovorawan 《Virus genes》2013,46(2):369-370
Phylogenetic analysis of partial ORF1 and ORF2 genes of Hepatitis E virus (HEV) strains from pigs in Thailand during 2011–2012 was performed. The result indicated that the current Thai strains belonged to the genotype 3 subgroup 3f, which were similar to the previous HEVs circulating in humans in Thailand. 相似文献
88.
Supchokpul A Chansaenroj J Theamboonlers A Payungporn S Kamolvarin N Sampathanukul P Junyangdikul P Swangvarees S Karalak A Poovorawan Y 《The Southeast Asian journal of tropical medicine and public health》2011,42(5):1113-1118
In some circumstances, infection with human papillomavirus (HPV), especially HPV type 16 (HPV16), progresses to cervical cancer. Viral E4 expression reflects viral replication and translation and its presence may rule out a latent infectious stage. Twenty cervical cytology samples with known HPV 16 infection of each cytological category namely, negative for intraepithelial lesion (NIL), low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL) and squamous carcinoma (SCC) were investigated by single-step quantitative RT PCR for HPV 16 E4 mRNA, which was not found in any NIL sample but in all LSIL and HSIL samples. Thus, E4 expression assay should be useful for determining precancerous states and may be suitable as an adjunct in cervical HPV testing. 相似文献
89.
Tontulawat P Pongsiri P Thongmee C Theamboonlers A Kamolvarin N Poovorawan Y 《The Southeast Asian journal of tropical medicine and public health》2011,42(3):570-578
Dengue virus (DENV) causes various clinical symptoms of differing severity based on time of infections. The existing laboratory methods, semi-nested PCR and Dengue IgM ELISA, still have limitations for diagnosis. A commercially available rapid immunochromatographic dengue NS1 antigen and IgM antibody tests in comparison with semi-nested PCR and IgM ELISA for confirmation of DENV infection were evaluated. In total, 237 single acute serum specimens and 50 paired sera of dengue patients were examined using the rapid dengue NS1 antigen test, IgM antibody test, semi-nested PCR and Dengue IgM ELISA. The NS1 and IgM rapid tests showed sensitivity of 70.6%, and 75.6%, respectively, and specificity of 73.4% and 97.1%, respectively. The combination of NS1 and IgM tests enhanced diagnosis. Thus rapid dengue NS1 antigen and IgM antibody tests are highly appropriate for diagnosis of dengue infection as it is rapid, easily applicable, sensitive and highly specific. 相似文献
90.
Honsawek S Praianantathavorn K Chongsrisawat V Vejchapipat P Theamboonlers A Poovorawan Y 《Pediatric surgery international》2011,27(7):681-687