全文获取类型
收费全文 | 542篇 |
免费 | 34篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 16篇 |
妇产科学 | 11篇 |
基础医学 | 72篇 |
口腔科学 | 12篇 |
临床医学 | 70篇 |
内科学 | 108篇 |
皮肤病学 | 17篇 |
神经病学 | 57篇 |
特种医学 | 12篇 |
外科学 | 53篇 |
预防医学 | 59篇 |
眼科学 | 23篇 |
药学 | 32篇 |
中国医学 | 5篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 5篇 |
2022年 | 15篇 |
2021年 | 12篇 |
2020年 | 7篇 |
2019年 | 11篇 |
2018年 | 14篇 |
2017年 | 15篇 |
2016年 | 13篇 |
2015年 | 13篇 |
2014年 | 16篇 |
2013年 | 28篇 |
2012年 | 36篇 |
2011年 | 35篇 |
2010年 | 32篇 |
2009年 | 14篇 |
2008年 | 30篇 |
2007年 | 32篇 |
2006年 | 32篇 |
2005年 | 30篇 |
2004年 | 33篇 |
2003年 | 15篇 |
2002年 | 12篇 |
2001年 | 12篇 |
2000年 | 5篇 |
1999年 | 10篇 |
1998年 | 13篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 5篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1967年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有577条查询结果,搜索用时 15 毫秒
21.
Larissa Fonseca da Cunha Sousa Fernanda Matos Coelho David Henrique Rodrigues Alline Cristina Campos Lucíola da Silva Barcelos Mauro Martins Teixeira Milene Alvarenga Rachid Antonio Lúcio Teixeira 《Clinics (S?o Paulo, Brazil)》2013,68(3):391-394
OBJECTIVE:
Ischemic stroke may result from transient or permanent reductions of regional cerebral blood flow. Polymorphonuclear neutrophils have been described as the earliest inflammatory cells to arrive in ischemic tissue. CXCR1/2 receptors are involved in the recruitment of these cells. However, the contribution of these chemokine receptors during transient brain ischemia in mice remains poorly understood. In this work, we investigated the effects of reparixin, an allosteric antagonist of CXCR1/2 receptors, in a model of middle cerebral artery occlusion and reperfusion in mice.METHODS:
C57BL/6J male mice treated with reparixin or vehicle were subjected to a middle cerebral artery occlusion procedure 1 h after the treatment. Ninety minutes after ischemia induction, the monofilament that prevented blood flow was removed. Twenty-four hours after the reperfusion procedure, behavioral changes, including motor signs, were analyzed with the SmithKline/Harwell/Imperial College/Royal Hospital/Phenotype Assessment (SHIRPA) battery. The animals were sacrificed, and brain tissue was removed for histological and biochemical analyses. Histological sections were stained with hematoxylin and eosin, neutrophil infiltration was estimated by myeloperoxidase activity and the inflammatory cytokine IL-1β was measured by ELISA.RESULTS:
Pre-treatment with reparixin reduced the motor deficits observed in this model of ischemia and reperfusion. Myeloperoxidase activity and IL-1β were reduced in the reparixin-treated group. Histological analysis revealed that ischemic injury was also attenuated by reparixin pre-treatment.CONCLUSIONS:
Our results suggest that the blockade of the CXCR1/2 receptors by reparixin promotes neuroprotective effects by reducing the levels of polymorphonuclear infiltration in the brain and the tissue damage associated with middle cerebral artery occlusion and reperfusion. 相似文献22.
23.
Carvalho SR Alvarenga Filho H Papais-Alvarenga RM Chacur FH Dias RM 《Respirology (Carlton, Vic.)》2012,17(5):869-875
Background and objective: Impairment of respiratory function has been described in end‐stage multiple sclerosis (MS), as well as in patients with mild to severe disability. No data are available regarding the respiratory function of MS patients without disability. The objective of this study was to assess the pulmonary function, respiratory muscle strength and carbon monoxide diffusion capacity of the lungs (DLCO) in patients with relapsing‐remitting multiple sclerosis (RRMS) without disability. Methods: Twenty‐seven RRMS patients and 25 healthy control subjects were recruited. All subjects underwent clinical and neurological examination, and spirometry; lung volumes, DLCO and maximal respiratory pressures were measured. All subjects were rated on the Modified Fatigue Impact Scale and Fatigue Severity Scale scales. Results: There were no significant differences in age, gender, height, weight or body mass index between the groups. The mean duration of illness in the MS group was 5.44 ± 3.74 years, and the mean Expanded Disability Status Scale was 0.62 ± 0.65. The mean values for total lung capacity, forced expiratory volume in 1 s (FEV1) and FEV1/FVC were normal in both groups. Fifteen RRMS patients exhibited a reduction in maximal expiratory pressure (MEP), but only one patient exhibited a reduction in maximal inspiratory pressure. The mean values for DLCO were lower in RRMS patients (P = 0.0004) than in the control group. DLCO was decreased in 15 (55.55%), out of 27 RRMS patients. The fatigue scale results were not correlated with pulmonary function test results Conclusions: DLCO and MEP may be impaired in RRMS patients without disability. 相似文献
24.
25.
Thiago Roberto Lima Romero Raquel Rodrigues Soares Santos Marina Gomes Miranda e Castor Júlia Alvarenga Petrocchi Luciana Souza Guzzo Andre Klein Igor Dimitri Gama Duarte 《Pharmacological reports : PR》2018,70(4):784-788
Background
The aim of this study was to investigate this involvement in not inflammatory model of pain and which opioid receptor subtype mediates noradrenaline-induced peripheral antinociception. Noradrenaline is involved in the intrinsic control of pain-inducing pro-nociceptive effects in the primary afferent nociceptors. However, inflammation can induce various plastic changes in the central and peripheral noradrenergic system that, upon interaction with the immune system, may contribute, in part, to peripheral antinociception.Methods
Hyperalgesia was induced by intraplantar injection of prostaglandin E2 (PGE2, 2 μg) into the plantar surface of the right hind paw and the paw pressure test to evaluated the hyperalgesia was used. Noradrenaline (NA) was administered locally into right hind paw of Wistar rat (160–200 g) alone and after either agents, α2-adrenoceptor antagonist yohimbine, α1-adrenoceptor antagonist prazosin, β-adrenoceptor antagonist propranolol, μ-opioid antagonist clocinnamox, δ-opioid antagonist naltrindole and κ-opioid antagonist nor-binaltorfimina. In addition, the enkephalinase inhibitor bestatin was administered prior to NA low dose.Results
Intraplantar injection of NA induced peripheral antinociception against hyperalgesia induced by PGE2. This effect was reversed, in dose dependent manner, by intraplantar injection of yohimbine, prazosin, propranolol, clocinnamox and naltrindole. However, injection of nor-binaltorfimina did not alter antinociception of NA after PGE2 hyperalgesia. Bestatin intensified the antinociceptive effects of low-dose of NA.Conclusion
Besides the α2-adrenoceptor, the present data provide evidence that, in absence of inflammation, NA activating α1 and β-adrenoceptor induce endogenous opioid release to produce peripheral antinociceptive effect by μ and δ opioid receptors. 相似文献26.
Alvarenga Livia Cardozo Ludmila F. M. F. Da Cruz Beatriz O. Paiva Bruna R. Fouque Denis Mafra Denise 《International urology and nephrology》2022,54(10):2645-2652
International Urology and Nephrology - Recent studies have shed light on the potential role of curcumin in mitigating inflammation in patients with chronic kidney disease (CKD). This study aimed to... 相似文献
27.
28.
29.
Edith U Ebeledike Godwin IC Nwokedi Okechukwu O Ndu Festus BC Okoye Izuchukwu S Ochiogu 《Asian Pacific journal of tropical medicine》2010,3(5):395-398
ObjectiveTo investigate the calcium and phosphorus contents of four domestic animals used as sources of meat in Nigeria.MethodsThe calcium contents of the body parts of the animals were determined using atomic absorption spectrometer. Their phosphorus contents were determined colorimetrically using the molybdenum blue method.ResultsThe calcium and phosphorus contents were significantly higher in the bone samples than in the other animal parts investigated (P<0.05). The calcium contents of all the edible parts were higher in chicken than in the other animals. High calcium and phosphorus contents were detected in the faeces of chicken and goat, and that of cattle and goat, respectively. Low calcium and phosphorus contents were detected in the urine samples. Calcium: phosphorus ratios calculated for the bones of chicken, cattle and goat were satisfactory.ConclusionsIn conclusion, calcium and phosphorus contents of the animal parts vary significantly and their relative contents may be related to the animal's diet. Chicken parts may be the preferred dietary source of these minerals. This study highlights the need for routine investigation of the mineral contents of food, which is necessary for proper nutritional guidelines. 相似文献
30.
Alister N. Hodge RN BN Grad. Cert. Critical Care Master of Emergency Nursing Andrea P. Marshall RN IC Cert. BN MN Grad. Cert. Ed. Studies 《Collegian (Royal College of Nursing, Australia)》2009,16(3):101-118
The practice of allowing family to be present during patient resuscitation or invasive procedures (Family Presence) is gaining acceptance in North America and the United Kingdom in controlled circumstances. Research into Family Presence has demonstrated multiple benefits for the patient, family and health care team. These advantages include helping the family to understand the severity of the illness/trauma and to see that appropriate attempts were undertaken to save their loved one. Family Presence can also facilitate improved communication between the health care team and family. In spite of evidence supporting Family Presence as a useful practice for patient, family and health care team, the use of Family Presence is uncommon within Australian emergency departments and hospitals. Clear expectations at organisational, governmental and professional levels are essential to effectively implement this approach. To be supported in the clinical area, the success of a Family Presence program requires an inclusive approach to program development. A critical component of a successful Family Presence program is a family facilitator who is adequately prepared for the role and committed to supporting the family during resuscitation or invasive procedures. Research exploring Family Presence in Australia is lacking and highlights the need for context specific research in this area. 相似文献