全文获取类型
收费全文 | 37721篇 |
免费 | 3048篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 466篇 |
儿科学 | 1256篇 |
妇产科学 | 1200篇 |
基础医学 | 4842篇 |
口腔科学 | 763篇 |
临床医学 | 5097篇 |
内科学 | 6332篇 |
皮肤病学 | 365篇 |
神经病学 | 3082篇 |
特种医学 | 1071篇 |
外科学 | 4833篇 |
综合类 | 819篇 |
一般理论 | 38篇 |
预防医学 | 4971篇 |
眼科学 | 617篇 |
药学 | 2622篇 |
1篇 | |
中国医学 | 67篇 |
肿瘤学 | 2381篇 |
出版年
2023年 | 243篇 |
2022年 | 368篇 |
2021年 | 715篇 |
2020年 | 469篇 |
2019年 | 747篇 |
2018年 | 857篇 |
2017年 | 575篇 |
2016年 | 658篇 |
2015年 | 732篇 |
2014年 | 1001篇 |
2013年 | 1435篇 |
2012年 | 2220篇 |
2011年 | 2216篇 |
2010年 | 1139篇 |
2009年 | 1013篇 |
2008年 | 1919篇 |
2007年 | 2040篇 |
2006年 | 1855篇 |
2005年 | 1789篇 |
2004年 | 1788篇 |
2003年 | 1612篇 |
2002年 | 1497篇 |
2001年 | 996篇 |
2000年 | 932篇 |
1999年 | 825篇 |
1998年 | 476篇 |
1997年 | 411篇 |
1996年 | 385篇 |
1995年 | 374篇 |
1994年 | 277篇 |
1993年 | 249篇 |
1992年 | 659篇 |
1991年 | 558篇 |
1990年 | 532篇 |
1989年 | 511篇 |
1988年 | 500篇 |
1987年 | 458篇 |
1986年 | 497篇 |
1985年 | 470篇 |
1984年 | 370篇 |
1983年 | 318篇 |
1982年 | 224篇 |
1981年 | 216篇 |
1980年 | 218篇 |
1979年 | 361篇 |
1978年 | 242篇 |
1977年 | 224篇 |
1974年 | 233篇 |
1973年 | 212篇 |
1969年 | 204篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
32.
D L Renfrew G Y el-Khoury T E Moore M H Kathol C G Whitten C W Walker M A Fraser-Hill 《Investigative radiology》1991,26(11):1019-1023
Although general suggestions have been made regarding a radiology residency curriculum, no specific list of entities has been offered. Over the past ten years, we have developed a resident-run morning conference in musculoskeletal radiology that is supervised by faculty and covers a specific curriculum. We offer our curriculum as an example that may assist other departments in developing their own curricula. 相似文献
33.
A patient with Hodgkin’s disease received a fractionated 3, 740 rad dosage over 4 weeks to a portal that included both kidneys. Three months later a computed tomographic scan obtained 2 hours after intravenous contrast injection demonstrated sharply demarcated, dense, persistent nephrograms corresponding to the irradiated areas. These changes are ascribed to acute radiation nephritis, reflecting tubular stasis and ischemia. 相似文献
34.
35.
Yubin Miao Said D Figueroa Darrell R Fisher Herbert A Moore Richard F Testa Timothy J Hoffman Thomas P Quinn 《Journal of nuclear medicine》2008,49(5):823-829
Peptide-targeted alpha-therapy with 7.4 MBq of (212)Pb-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-ReO-[Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) ((212)Pb-DOTA-Re(Arg(11))CCMSH) cured 45% of B16/F1 murine melanoma-bearing C57 mice in a 120-d study, highlighting its melanoma treatment potential. However, there is a need to develop an imaging surrogate for patient-specific dosimetry and to monitor the tumor response to (212)Pb-DOTA-Re(Arg(11))CCMSH therapy. The purpose of this study was to evaluate the potential of (203)Pb-DOTA-Re(Arg(11))CCMSH as a matched-pair SPECT agent for (212)Pb-DOTA-Re(Arg(11))CCMSH. METHODS: DOTA-Re(Arg(11))CCMSH was labeled with (203)Pb in 0.5 M NH(4)OAc buffer at pH 5.4. The internalization and efflux of (203)Pb-DOTA-Re(Arg(11))CCMSH were determined in B16/F1 melanoma cells. The pharmacokinetics of (203)Pb-DOTA-Re(Arg(11))CCMSH was examined in B16/F1 melanoma-bearing C57 mice. A micro-SPECT/CT study was performed with (203)Pb-DOTA-Re(Arg(11))CCMSH in a B16/F1 melanoma-bearing C57 mouse at 2 h after injection. RESULTS: (203)Pb-DOTA-Re(Arg(11))CCMSH was easily prepared in NH(4)OAc buffer and completely separated from the excess nonradiolabeled peptide by reversed-phase high-performance liquid chromatography (RP-HPLC). (203)Pb-DOTA-Re(Arg(11))CCMSH displayed fast internalization and extended retention in B16/F1 cells. Approximately 73% of (203)Pb-DOTA-Re(Arg(11))CCMSH activity internalized after a 20-min incubation at 25 degrees C. After incubation of the cells in culture medium for 20 min, 78% of internalized activity remained in the cells. (203)Pb-DOTA-Re(Arg(11))CCMSH exhibited a biodistribution pattern similar to that of (212)Pb-DOTA-Re(Arg(11))CCMSH in B16/F1 melanoma-bearing mice. (203)Pb-DOTA-Re(Arg(11))CCMSH exhibited a peak tumor uptake of 12.00+/-3.20 percentage injected dose per gram (%ID/g) at 1 h after injection. The tumor uptake gradually decreased to 3.43+/-1.12 %ID/g at 48 h after injection. (203)Pb-DOTA-Re(Arg(11))CCMSH exhibited a peak tumor-to-kidney uptake ratio of 1.53 at 2 h after injection. The absorbed doses to the tumor and kidneys were 4.32 and 4.35 Gy, respectively, per 37 MBq. Whole-body clearance of (203)Pb-DOTA-Re(Arg(11))CCMSH was fast, with approximately 89% of the injected activity cleared through the urinary system by 2 h after injection. (203)Pb showed 1.6-mm SPECT resolution, which was comparable to (99m)Tc. Melanoma lesions were visualized through SPECT/CT images of (203)Pb-DOTA-Re(Arg(11))CCMSH at 2 h after injection. CONCLUSION: (203)Pb-DOTA-Re(Arg(11))CCMSH exhibited favorable pharmacokinetic and tumor imaging properties, highlighting its potential as a matched-pair SPECT agent for (212)Pb-DOTA-Re(Arg(11))CCMSH melanoma treatment. 相似文献
36.
37.
38.
39.
Using Syva EMIT reagents and a Cobas Bio centrifugal analyser we have developed a cost-effective assay for the detection of cannabinoids in urine. With this method, up to 1500 samples can be assayed with a single 100 test kit while maintaining acceptable precision. A mean CV of 6.1% was obtained for the concentration range 80-130 micrograms/l. The method is suitable for high-risk urines since heart treatment may be performed prior to analysis. There was no significant change in the measured concentration of cannabinoids in urine samples on storage in plastic containers, refrigerated or frozen, for up to seven weeks. 相似文献
40.