l-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety via sustainable sonochemical approach

The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established via the reaction of N-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification.

The l-proline catalyzed ultrasonic-mediated synthesis of polysubstituted pyridone derivatives through the reaction of N-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidenes has demonstrated as an efficient protocol.     

Prevalence and impact of comorbidities on disease prognosis among patients with COVID-19 in Bangladesh: A nationwide study amid the second wave

BackgroundSocio-demographics and comorbidities are involved in determining the severity and fatality in patients with COVID-19 suggested by studies in various countries, but study in Bangladesh is insufficient.AimsWe designed the study to evaluate the association of sociodemographic and comorbidities with the prognosis of adverse health outcomes in patients with COVID-19 in Bangladesh.MethodsA multivariate retrospective cohort study was conducted on data from 966 RT-PCR positive patients from eight divisions during December 13, 2020, to February 13, 2021. Variables included sociodemographic, comorbidities, symptoms, Charlson comorbidity index (CCI) and access to health facilities. Major outcome was fatality. Secondary outcomes included hospitalization, duration of hospital stay, requirement of mechanical ventilation and severity.ResultsMale (65.8%, 636 of 966) was predominant and mean age was 39.8 ± 12.6 years. Fever (79%), dry cough (55%), and loss of test/smell (51%) were frequent and 74% patients had >3 symptoms. Fatality was recorded in 10.5% patients. Comorbidities were found in 44% patients. Hypertension (21.5%) diabetes (14.6%), and cardiovascular diseases (11.3%) were most prevalent. Age >60 years (OR: 4.83, 95% CI: 2.45–6.49), and CCI >3 (OR: 5.48, 95% CI: 3.95–7.24) were predictors of hospitalizations. CCI >4 (aOR: 3.41, 95% CI: 2.57–6.09) was predictor of severity. Age >60 years (aOR: 3.77, 95% CI: 1.07–6.34), >3 symptoms (aOR: 2.14, 95% CI: 0.97–4.91) and CCI >3 vs. CCI <3 (aOR: 5.23, 95% CI: 3.77–8.09) were independently associated with fatality.ConclusionsIncreased age, >3 symptoms, increasing comorbidities, higher CCI were associated with increased hospitalization, severity and fatality in patients with COVID-19.     

Recent Advances in Polymer Nanocomposites Based on Polyethylene and Polyvinylchloride for Power Cables

Polymer nanocomposites used in underground cables have been of great interest to researchers over the past 10 years. Their preparation and the dispersion of the nanoparticles through the polymer host matrix are the key factors leading to their enhanced dielectric properties. Their important dielectric properties are breakdown strength, permittivity, conductivity, dielectric loss, space charge accumulation, tracking, and erosion, and partial discharge. An overview of recent advances in polymer nanocomposites based on LDPE, HDPE, XLPE, and PVC is presented, focusing on their preparation and electrical properties.     

Failure Mechanism of Hybrid Steel Beams with Trapezoidal Corrugated-Web Non-Welded Inclined Folds

Literature of Steel Beams with a thin-walled trapezoidal Corrugated Web (SBCWs) shows that the capacity of SBCWs is affected by both the fatigue cracks initiated along the inclined folds (IFs) and the maximal additional stress located in the middle of the IFs. An experimental investigation on the behaviour of hybrid SBCWs under flexure is presented in this paper. This study focuses on the effect of the welding IF between the web and flanges (IFs welded or non-welded), the horizontal-fold length (200, 260, and 350 mm), and transversal flange stiffeners on the failure mechanism of the SBCW under three line load. Accordingly, six hybrid specimens were fabricated, instrumented, and tested (five SBCW specimens and one specimen with a flat web). The test setup was designed to generate shear and a moment in the testing zone via three-point bending. The results indicated that non-welded IFs specimens with or without flange stiffeners failed owing to web tearing after web and flange local buckling. The failure mode of the specimen with continuous welding between the web and flanges was local flange buckling. Finally, the paper presents a comparison between the experimental results and the European Code to predict the capacity of the flange towards local buckling. It was concluded that the non-welding the IFs affected the inelastic behaviour and the capacity of the SBCWs. In addition, the bending resistance equations presented by EN 1993-1-5 can safely predict the test results of the non-welded inclined fold and yield a high safe variation.     

Reducing radiation dose for multi-phase contrast-enhanced dual energy renal CT: pilot study evaluating prior iterative reconstruction

Abdominal Radiology - Prior iterative reconstruction (PIR) uses spatial information from one phase of enhancement to reduce image noise in other phases. We sought to determine if PIR could reduce...     

Potential of Bacillus sp. LG7 as a Promising Source of Ligninolytic Enzymes for Industrial and Biotechnological Applications

Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Ligninolytic bacteria are considered a major source of ligninolytic enzymes, which are widely used in a...