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Aref Salehzadeh Behrooz Shisheian Ali Rafaat Ali Nikkhah Tahereh Rezaii 《Drug and chemical toxicology》2019,42(3):280-285
Pesticides are introduced into the environment in a variety of ways and constitute a wide group of environmental pollutants. To evaluate the attenuating effects of sesame oil on the toxicity of diazinon (DZN), male Wistar rats were exposed to DZN and/or sesame oil by gavage at different dosages for 8?weeks. DZN in a concentration of 30?mg/kg caused an increase in the number of white blood cell (WBCs), and the combination of DZN and sesame oil raised the number of platelets; the number of red blood cells, however, did not change. In addition, DZN caused a drastic decrease in the sperm count in a dose-dependent manner and in a concentration of 50?mg/kg, the sperm count decreased by more than 50%, but the combination of sesame oil in a dose of 4?ml/kg with DZN reversed the effect of this pesticide. The evidence presented here suggests that in addition to antioxidants, such as olive oil, intermittent exposure with sufficient intervals can decrease the toxicity of pesticides. 相似文献
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Nima Motamed Hossein Ajdarkosh Mohammad Hadi Karbalaie Niya Mahshid Panahi Behzad Farahani Nader Rezaie Mehdi Nikkhah Amir H. Faraji Gholamreza Hemmasi Dhayaneethie Perumal G. Hossein Ashrafi Fahimeh Safarnezhad Tameshkel Esmaeel Gholizadeh Mahmoodreza Khoonsari Farhad Zamani 《Clinical cardiology》2022,45(6):641
Background and AimsContinuous scoring systems were developed versus traditional dichotomous approaches to define metabolic syndrome. The current study was carried out to evaluate the ability of scoring systems to predict fatal and nonfatal cardiovascular events.Materials and MethodsThe data of 5147 individuals aged 18 years or more obtained from a population‐based cohort study were analyzed. The occurrence of atherosclerotic cardiovascular disease (ASCVD) in the period of 7 years follow‐up was considered as the associated outcome. Joint Interim Statement (JIS) definition, as a traditional definition of metabolic syndrome (MetS), and two versions of MetS scoring systems, based on standardized regression weights from structural equation modeling (SEM) and simple method for quantifying metabolic syndrome (siMS) were considered as potential predictors.ResultsThe scoring systems, particularly, based on SEM, were observed to have a significant association with composite cardiovascular events (HR = 1.388 [95% CI = 1.153–1.670], p = .001 in men and HR = 1.307 [0.95% CI = 1.120–1.526] in women) in multiple Cox proportional hazard regression analyses, whereas the traditional definition of MetS did not show any significant association. While both two scoring systems showed acceptable predictive abilities for cardiovascular events in women (MetS score based on SEM: area of under curve [AUC] = 0.7438 [95% CI = 0.6195–0.7903] and siMS: AUC = 0.7207 [95% CI = 0.6676–0.7738]), the two systems were not acceptable for identifying risk in men.ConclusionUnlike the dichotomous definition of MetS, the scoring systems showed an independent association with cardiovascular events. Scoring systems, particularly those based on SEM, may be useful for the prediction of cardiovascular events in women. 相似文献
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U. Tacke D. Karger J. Spreer A. Berlis G. Nikkhah R. Korinthenberg 《Child's nervous system》2011,27(6):961-966