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91.
92.
Diagnosis and treatment of latent tuberculosis infection in liver transplant recipients in an endemic area 总被引:2,自引:0,他引:2
Benito N Sued O Moreno A Horcajada JP González J Navasa M Rimola A 《Transplantation》2002,74(10):1381-1386
BACKGROUND: Treatment of latent tuberculosis infection (LTBI) with isoniazid is recommended for transplant recipients with positive tuberculin skin test (TST). However, TST could be an imperfect identifier of LTBI in this population. In addition, the risk of isoniazid hepatotoxicity could be high in liver transplant recipients (LTR). A retrospective cohort study was performed to evaluate the diagnosis and treatment of LTBI in LTR. METHODS: Charts of all 547 patients who received primary liver transplantation at a University Hospital in Spain between 1988 and 1998 were reviewed. RESULTS: TST was performed in 373 patients (71%) before transplantation. The result was positive in 89 (24%). The median follow-up after transplantation was 49 months. None of the TST-positive patients developed tuberculosis (TB), but 5 out of 284 patients with negative TST (1.76%) had active TB (P=0.6). Twenty-three patients received isoniazid as treatment of LTBI according to the decision of the attending physician. None of these patients developed TB, but 4 of them (17%) presented isoniazid hepatotoxicity. Among patients who did not receive isoniazid, 2 out of 21 (9.52%) with radiologic previous TB developed active TB versus 0.44% (2/452) among the remaining patients (relative risk [RR], 27.8, 95% CI, 3.2-147). CONCLUSIONS: Treatment of LTBI with isoniazid can not be recommended to LTR on the basis of a positive TST because it is an imperfect identifier of patients at risk of TB. LTR with radiologic features of previous TB are at higher risk of posttransplant active TB. Isoniazid-related hepatotoxicity is more frequent among LTR than in the general population. 相似文献
93.
Vicente Conesa MA Garcia-Martinez E Gonzalez Billalabeitia E Chaves Benito A Garcia Garcia T Vicente Garcia V Ayala de la Peña F 《Breast (Edinburgh, Scotland)》2012,21(4):468-474
Peripheral blood lymphocyte (PBL) count may reflect the immune status of cancer patients. We retrospectively analyzed the predictive and prognostic impact of baseline and post-chemotherapy PBL counts in a homogeneous group of 103 breast cancer patients treated with neoadjuvant chemotherapy (anthracyclines and taxanes). In univariate analysis, baseline PBL under 1500 × 10(6)/L (p = 0.013; hazard ratio [HR]: 2.80, 95%CI 1.24-6.61), and PBL decrease >200 × 10(6)/L after the first cycle of chemotherapy (p = 0.047; HR: 2.82, 95%CI 1.01-7.86) were significantly related to disease free survival. In multivariate analysis, both baseline PBL count less than 1500 × 10(6)/L (p = 0.034; HR: 3.32, 95%CI 1.09-10.02) and PBL decrease >200 × 10(6)/L after first cycle (p = 0.032; HR: 3.25, 95%CI 1.10-9.56) showed independent prognostic value for worse disease free survival. No effect was observed for overall survival. Our data support the relevance of pre- and post-chemotherapy PBL for breast cancer recurrence after neoadjuvant chemotherapy. 相似文献
94.
Porcaro Antonio Benito Tafuri Alessandro Panunzio Andrea Mazzucato Giovanni Cerrato Clara Gallina Sebastian Bianchi Alberto Rizzetto Riccardo Amigoni Nelia Serafin Emanuele Cianflone Francesco Orlando Rossella Gentile Ilaria Migliorini Filippo Zecchini Antoniolli Stefano Di Filippo Giacomo Brunelli Matteo Pagliarulo Vincenzo Cerruto Maria Angela Antonelli Alessandro 《International urology and nephrology》2022,54(3):541-550
International Urology and Nephrology - To evaluate the influence of endogenous testosterone density (ETD) on pelvic lymph node invasion (PLNI) in high risk (HR) prostate cancer (PCa) treated with... 相似文献
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98.
Rafaela Muñoz Carrasco Marina Álvarez Benito Elisa Muñoz Gomariz José Luis Raya Povedano María Martínez Paredes 《European radiology》2010,20(12):2797-2805
Objective
To assess clinical variables that may be useful in differentiating gynaecomastia from carcinoma and to analyse the contribution of mammography and ultrasound to the evaluation of male breast disease. 相似文献99.
Benito FC 《Revista espa?ola de cardiología》2000,53(7):998-1000
A 17 year old man with transposition of the great vessels who had two episodes of late recurrent syncope following Senning repair 2 months before hospital registration. One episode required basic cardiopulmonary reanimation. Holter monitoring documented isolated polytopic and coupled ventricular extrasystoles. Programmed left ventricular pacing induced polymorphous ventricular tachycardia, which converted to monomorphic sustained ventricular tachycardia after intravenous procainamide. A cardioverter defibrillator was implanted in left ventricle by intravenous approach. Twelve months later the patient presented an episode of polymorphic ventricular tachycardia and one appropriate therapy from the defibrillator discharge was done. 相似文献
100.