全文获取类型
收费全文 | 7307篇 |
免费 | 456篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 204篇 |
妇产科学 | 102篇 |
基础医学 | 993篇 |
口腔科学 | 950篇 |
临床医学 | 483篇 |
内科学 | 1473篇 |
皮肤病学 | 169篇 |
神经病学 | 440篇 |
特种医学 | 233篇 |
外科学 | 733篇 |
综合类 | 302篇 |
预防医学 | 799篇 |
眼科学 | 120篇 |
药学 | 452篇 |
1篇 | |
中国医学 | 64篇 |
肿瘤学 | 190篇 |
出版年
2023年 | 67篇 |
2022年 | 172篇 |
2021年 | 241篇 |
2020年 | 193篇 |
2019年 | 229篇 |
2018年 | 306篇 |
2017年 | 183篇 |
2016年 | 204篇 |
2015年 | 268篇 |
2014年 | 332篇 |
2013年 | 393篇 |
2012年 | 555篇 |
2011年 | 639篇 |
2010年 | 343篇 |
2009年 | 307篇 |
2008年 | 409篇 |
2007年 | 449篇 |
2006年 | 357篇 |
2005年 | 275篇 |
2004年 | 237篇 |
2003年 | 166篇 |
2002年 | 186篇 |
2001年 | 148篇 |
2000年 | 127篇 |
1999年 | 124篇 |
1998年 | 53篇 |
1997年 | 46篇 |
1996年 | 42篇 |
1995年 | 30篇 |
1994年 | 43篇 |
1993年 | 21篇 |
1992年 | 50篇 |
1991年 | 50篇 |
1990年 | 33篇 |
1989年 | 48篇 |
1988年 | 37篇 |
1987年 | 43篇 |
1986年 | 43篇 |
1985年 | 30篇 |
1984年 | 31篇 |
1983年 | 23篇 |
1982年 | 25篇 |
1979年 | 16篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1976年 | 17篇 |
1975年 | 15篇 |
1970年 | 20篇 |
1968年 | 20篇 |
1967年 | 13篇 |
排序方式: 共有7785条查询结果,搜索用时 15 毫秒
71.
72.
73.
Shyrar Tanussiya Ramu Madushika Dissanayake Chandima Jeewandara Farha Bary Michael Harvie Laksiri Gomes Ayesha Wijesinghe Dinuka Ariyaratne Graham S. Ogg Gathsaurie Neelika Malavige 《Immunology》2023,170(1):47-59
To further understand the role of NS1-specific antibodies (Abs) in disease pathogenesis, we compared neutralizing antibody levels (Nabs), NS1-Ab levels, IgG antibody subclass profiles and NS1-specific memory B-cell responses (Bmems) in individuals, with varying severity of past dengue. Nabs (Neut50 titres) were assessed using the Foci Reduction Neutralization Test (FRNT) and in-house ELISAs were used to assess NS1-Abs and NS1-Ab subclasses for all four DENV serotypes in individuals with past DF (n = 22), those with past DHF (n = 14) and seronegative (SN) individuals (n = 7). B-cell ELISpot assays were used to assess NS1-specific Bmem responses. 15/22 (68.18%) individuals with past DF and 9/14 (64.29%) individuals with past DHF had heterotypic infections. Neut50 titres were found to be significantly higher for DENV1 than DENV2 (p = 0.0006) and DENV4 (p = 0.0127), in those with past DHF, whereas there was no significant difference seen in titres for different DENV serotypes in those with past DF. Overall NS1-Ab to all serotypes and NS1-specific IgG1 responses for DENV1, 2 and 4 serotypes were significantly higher in those with past DHF than individuals with past DF. Those with past DHF also had higher IgG1 than IgG3 for DENV1 and DENV3, whereas no differences were seen in those with past DF. Over 50% of those with past DF or DHF had NS1-specific Bmem responses to >2 DENV serotypes. There was no difference in the frequency of Bmem responses to any of the DENV serotypes between individuals with past DF and DHF. Although the frequency of Bmem responses to DENV1 correlated with DENV1-specific NS1-Abs levels (Spearman r = 0.35, p = 0.02), there was no correlation with other DENV serotypes. We found that those with past DF had broadly cross-reactive Nabs, while those with past DHF had higher NS1-Ab responses possibly with a different functionality profile than those with past DF. Therefore, it would be important to further evaluate the functionality of NS1-specific antibody and Bmem responses to find out the type of antibody repertoire that is associated with protection against severe disease. 相似文献
74.
Vinicio Granados-Soto Marcelo de O. Rufino Lúcia D. Gomes Lopes Srgio H. Ferreira 《European journal of pharmacology》1997,340(2-3)
The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat. Saline, NG-monomethyl-
-arginine, a nitric oxide synthesis inhibitor (50 μg) and methylene blue, a guanylate cyclase inhibitor (500 μg), did not exhibit any antinociceptive activity. However, morphine (10 μg) produced a significant antinociceptive effect in phases 2a and 2b, which was reduced by pretreatment with either NG-monomethyl-
-arginine or methylene blue. These results suggest that the local administration of morphine induces antinociception by the activation of the
-arginine–nitric oxide–cGMP pathway. 相似文献
Full-size image
Full-size image
Full-size image
75.
Aneurysm of sinus of Valsalva dissecting into interventricular septum is a rare entity. We report one such case who was incidentally diagnosed by echocardiography to have this abnormality during evaluation of a clinically suspected isolated aortic regurgitation.KEY WORDS: Aneurysm – dissecting – sinus of Valsalva, Echocardiography 相似文献
76.
Rhinosporidiosis is a rare fungal disease resulting from infection by Rhinosporidium seeberi. There seems to be a relationship between the disease and agriculture, suggesting that Rhinosporidium lives in soil, and many authors agree that water is a necessary medium of transmission. The sites of infection are the nose (most common), eye, nasopharynx, penile urethra and external ear. Nasal cases generally present obstruction, epistaxis, watery or mucopurulent discharge, presence of tumoral pedunculated polypoid mass, generally with septal implantation. Histological examination presents characteristic sporangia in large numbers and in the submucosa a granulomatous host response. The treatment is by surgical excision (recurrence occurs in 10% of cases), and medical treatment used diaminodiphenylsulfone or Amphotericin B to avoid recurrent cases. We present a case of Rhinosporidiosis in a 10 years-old child, female, with 3 months history of nasal obstruction, epistaxis and presence of nasal mass in left nasal cavity that was submitted to surgical excision. 相似文献
77.
78.
79.
80.
Nakamura-Palacios EM de Oliveira RW Gomes CF 《Progress in neuro-psychopharmacology & biological psychiatry》1999,23(8):1369-1388
1. Effects of diazepam (DZP) or haloperidol (HAL) on convulsions and behavioral responses (locomotion, circling, spying and head shaking) induced by bilateral electrical stimulation in the medial prefrontal cortex (mPFC) were examined. 2. Male Wistar rats were electrically stimulated (ten 30-sec trains, 60 Hz, 80-100 microA) bilaterally in the mPFC and their behavior was simultaneously observed in an open field in daily session. 3. DZP and HAL dose-response curves (0, 0.5, 1.25, 2.5 and 5 mg/kg, i.p., 30 min before electrical stimulation session) were determined after a baseline of behavioral responses was established. 4. DZP dose-dependently decreased head shaking and convulsions, had no effect in circling and spying behaviors, and increased locomotion except at the highest dose. HAL reduced locomotion, circling and spying behaviors in a dose-dependent manner, but did not affect convulsions or head shaking. 5. These results demonstrated that convulsion and behavioral responses induced by electrical activation of the mPFC were modified by DZP or HAL. Therefore, the mPFC is involved in the mediation of neural and/or behavioral activity that may be implicated in some central effects of psychoactive drugs. 相似文献