硝酸舍他康唑栓治疗外阴阴道假丝酵母菌病28例

［摘要］目的评价硝酸舍他康唑栓治疗外阴阴道假丝酵母菌病的疗效及安全性。方法采用随机双盲对照试验。治疗组及对照组各30例,分别外用硝酸舍他康唑栓300 mg和克霉唑栓500 mg,用药1或2次。停药后（7±1） d及28～35 d时进行观察。结果治疗组28例、对照组30例纳入分析,治疗组和对照组停药后（7±1） d临床有效率分别为89.29%,86.67%（P＞0.05）;用药结束后28～35 d时的临床有效率分别为81.48%,66.67%（P＞0.05）;均未发生与药物相关的不良反应。结论硝酸舍他康唑栓治疗外阴阴道假丝酵母菌病有效,安全。     

22q11微缺失所致先心病的产前诊断

目的 探讨在先心病胎儿中进行22q11微缺失产前诊断的必要性及可行性.方法 对产前胎儿超声检查诊断为先天性心脏畸形的孕妇16例行羊膜腔穿刺或脐静脉穿刺获取胎儿细胞,并行染色体核型分析及双色荧光原位杂交检测22q11微缺失.结果 16例中检出22q11微缺失1例.结论 在先心病胎儿中行22q11微缺失产前诊断是有必要的,...     

Haglund综合征的放散状冲击波治疗效果观察

目的 观察DOLORCLAST(R) 放散状冲击波对Haglund综合征的临床治疗效果. 方法 选择治疗35例门诊Haglund综合征患者,采用DOLORCLAST(R) 放散状冲击波治疗机进行标准治疗,冲击波频率为12Hz,治疗探头15 mm,治疗压力3.0bar,冲击波次数2000,手持压力中～高,治疗次数3～5次,治疗周期7天. 结果 治疗后疼痛缓解,功能也有明显的改善,治疗后的治愈率31.43%,有效率94.28%;6周后的治愈率42.86%,有效率97.14%. 结论 DOLORCLAST(R) 放散状冲击波治疗Haglund综合征的治疗效果确切、操作简单、无创伤、易于患者接受和推广.     

舒巴坦在治疗耐碳青霉烯鲍曼不动杆菌医院获得性肺炎中的作用

近年来,碳青酶烯类抗菌药物曾经是治疗鲍曼不动杆菌感染的有效药物,但国内外已报道耐碳青酶烯类鲍曼不动杆菌逐年增多[1]。多重耐药鲍曼不动杆菌对临床常用抗生素β-内酰胺类、氨基糖苷类、氟喹诺酮类抗菌药物敏感性逐渐减低,耐碳青酶烯类鲍曼不动杆菌医院获得性肺炎的治疗成为临床棘     

Effect of 935-MHz phone-simulating electromagnetic radiation on endometrial glandular cells during mouse embryo implantation

This study examined the impact of 935MHz phone-simulating electromagnetic radiation on embryo implantation of pregnant mice.Each 7-week-old Kunming (KM) female white mouse was set up with a KM male mouse in a single cage for mating overnight after induction of ovulation.In the first three days of pregnancy,the pregnant mice was exposed to electromagnetic radiation at low-intensity (150 μW/cm2,ranging from 130 to 200 μW/cm2,for 2-or 4-h exposure every day),mid-intensity (570 μW/cm2,ranging from 400 to 700 μW/cm2,for 2-or 4-h exposure every day) or high-intensity (1400 μW/cm2,ranging from 1200 to 1500 μW/cm2,for 2-or 4-h exposure every day),respectively.On the day 4 after gestation (known as the window of murine embryo implantation),the endometrium was collected and the suspension of endometrial glandular cells was made.Laser scanning microscopy was employed to detect the mitochondrial membrane potential and intracellular calcium ion concentration.In high-intensity,2-and 4-h groups,mitochondrial membrane potential of endometrial glandular cells was significantly lower than that in the normal control group (P<0.05).The calcium ion concentration was increased in low-intensity 2-h group but decreased in high-intensity 4-h group as compared with the normal control group (P<0.05).However,no significant difference was found in mitochondrial membrane potential of endometrial glandular cells between low-or mid-intensity groups and the normal control group,indicating stronger intensity of the electromagnetic radiation and longer length of the radiation are required to inflict a remarkable functional and structural damage to mitochondrial membrane.Our data demonstrated that electromagnetic radiation with a 935-MHz phone for 4 h conspicuously decreased mitochondrial membrane potential and lowered the calcium ion concentration of endometrial glandular cells.It is suggested that high-intensity electromagnetic radiation is very likely to induce the death of embryonic cells and decrease the chance of their implantati     

健康教育计划护理对提高外耳再造患者遵医行为的影响

以往五官科护理多以医嘱为中心．注重治疗．忽视对患者相关知识教育与心理支持．致使手术成功率低．围手术期并发症发生率高．并直接影响患者心身健康．加重经济负担。为了改变以上护理弊端．自2009年至今我们将健康教育计划护理贯穿于整个围手术期。取得较好效果,现报道如下。     

精神心理学干预在慢性疼痛治疗中的应用研究进展

越来越多的研究关注精神心理学参与慢性疼痛的治疗,在临床中不断有报道提出慢性疼痛复合心理干预有效,并能综合的改善患者的生活质量.常见慢性疼痛的心理学干预包括心理药理学干预与心理行为学干预,均对慢性疼痛的改善有效.     

清热利湿颗粒提取工艺的实验研究

目的优选清热利湿颗粒的最佳提取工艺。方法水提取工艺以黄柏单煎,采用正交设计法以浸膏得率和盐酸小檗碱含量为考察指标;赤芍等8味药材合煎,采用正交设计法以浸膏得率和芍药苷含量为考察指标,优选最佳提取工艺条件。结果清热利湿颗粒最佳工艺条件：黄柏单煎加入10倍量水,煎煮2次,每次1.5 h;赤芍等药材加入10倍量水,煎煮2次,每次2小时。结论优选出的提取条件科学合理,提取工艺经验证,重现性较好,有效成分转移率较高。     

正交试验法优选再造浓缩丸的醇提工艺

优选再造浓缩丸的提取工艺条件。方法：以柚皮苷含量作为主要考核指标,采用正交试验法对醇提工艺条件进行优选。结果：最佳的工艺为加用8倍量70％乙醇,回流提取2次,每次1．0h。结论：该工艺可行。     

低血糖脑病临床诊治分析

目的:探讨低血糖脑病的病因、临床特征、治疗及预后,提高对低血糖脑病的认识和诊治水平.方法:收集低血糖脑病22例患者,对其临床表现、治疗方法、预后进行总结、分析.结果:低血糖脑病经积极治疗后,22例均恢复良好,未遗留神经精神症状.结论:低血糖脑病如能及时诊治,预后良好