按WHO分型及Masaoka分期回顾性分析110例胸腺瘤

1999年世界卫生组织(WHO)为规范胸腺瘤分类,公布了WHO组织学分型标准.现通过对我们收治的110例胸腺瘤病人进行同顾性分析,探讨WHO分型与胸腺瘤分期和预后的相关性.     

按WHO分型及Masaoka分期回顾性分析110例胸腺瘤

1999年世界卫生组织(WHO)为规范胸腺瘤分类,公布了WHO组织学分型标准.现通过对我们收治的110例胸腺瘤病人进行同顾性分析,探讨WHO分型与胸腺瘤分期和预后的相关性.     

Cyclin E的表达和乳腺癌的预后的meta分析

背景与目的：多个临床试验分析了cyclin E与乳腺癌预后的关系，但结果并不一致。本研究对已发表的相关临床试验结果进行再分析，从而探讨肿瘤组织的细胞周期素E（cyclin E）的表达水平是否是乳腺癌的预后因素。方法：检索PubMed以及CBMDisc数据库中研究cyclinE表达与乳腺癌预后关系的文献，使用meta分析的方法分析cyclinE是否为乳腺癌的预后因素。结果：共有13篇符合要求的文献，包括患者的总数为2644人。各个研究之间在病例选择、随访时间、辅助治疗、检测方法以及表达水平的判定标准等方面存在明显的差异。合并的单因素及多因素分析结果显示，高cyclinE水平患者的无复发生存率（RFS）的危险比（HR）分别为2．26（95％CI：1．41—3．61）和1．72（95％CI：0．95—3．10）；高cyclinE水平患者的总生存率（OS）／乳腺癌相关生存率（BCSS）的HR分别为2．74（95％CI：2．22-3．39）和2．86（95％CI：1．85-4．41）。在淋巴结阴性的患者中，合并的高cyclinE水平患者OS的HR为3．40（95％CI：2．20-5．26）。结论：cyclin E可能是乳腺癌OS独立的预后因素，但该结论尚需进一步的大规模临床试验加以验证。     

68例老年患者慢性硬脑膜下血肿临床分析

我科1995年～2002年共收治老年慢性硬膜下血肿(CSH)68例.经手术治疗,加强术后神经康复治疗,收到较好疗效,分析报告如下.     

空洞型非小细胞肺癌的预后分析

Objective To explore the survival and prognostic status of the cavitating non-small cell lung cancer. Methods A total 42 surgically treated patients with cavitating non-small cell lung cancer were studied retrospectively. Kaplan-Meiei was used to analyze the relationship between the prognostic factors and survival time. The cavitaing non-small cell lung cancer were matched 1:2 to the patients with non-small cell lung cancer that there is no cavity in X-ray, for gender, age, histology, lymph nodes dissection, stage, and whether receiving chemotherapy. The two groups were compared using the Log-rank test. Results The overall 1, 3, 5- year- survival rates for cavitating non-small cell lung cancer were 76.2%, 28.6%, and 14.7%, respectively. The diameter of the cavity and lymph nodes status significantly influenced syrvivals. 1he overall syrvival between the two groups of patients showed no sig- nificant differences (P=0.075). But the factors of women(P=O.040), younger than 60 years(P =0.032), NO of the lymph nodes dissection group(P=0.046), and staging Ⅰ were significantly influenced 5-year survivals(P=0.048). Conclusion The diameter of the cavity and lymph nodes status were correlated with the survival. The carcinomatous cavity are important prognosis factors for the nan-retail cell lung cancer patients of younger than 60 years, negative of lymph nodes dissection and staging Ⅰ , but whether the carci- nomtous cavity are important prognosis factors for the non-small cell lung cancer patients of woman was not determined.     

空洞型非小细胞肺癌的预后分析

Objective To explore the survival and prognostic status of the cavitating non-small cell lung cancer. Methods A total 42 surgically treated patients with cavitating non-small cell lung cancer were studied retrospectively. Kaplan-Meiei was used to analyze the relationship between the prognostic factors and survival time. The cavitaing non-small cell lung cancer were matched 1:2 to the patients with non-small cell lung cancer that there is no cavity in X-ray, for gender, age, histology, lymph nodes dissection, stage, and whether receiving chemotherapy. The two groups were compared using the Log-rank test. Results The overall 1, 3, 5- year- survival rates for cavitating non-small cell lung cancer were 76.2%, 28.6%, and 14.7%, respectively. The diameter of the cavity and lymph nodes status significantly influenced syrvivals. 1he overall syrvival between the two groups of patients showed no sig- nificant differences (P=0.075). But the factors of women(P=O.040), younger than 60 years(P =0.032), NO of the lymph nodes dissection group(P=0.046), and staging Ⅰ were significantly influenced 5-year survivals(P=0.048). Conclusion The diameter of the cavity and lymph nodes status were correlated with the survival. The carcinomatous cavity are important prognosis factors for the nan-retail cell lung cancer patients of younger than 60 years, negative of lymph nodes dissection and staging Ⅰ , but whether the carci- nomtous cavity are important prognosis factors for the non-small cell lung cancer patients of woman was not determined.     

空洞型非小细胞肺癌的预后分析

Objective To explore the survival and prognostic status of the cavitating non-small cell lung cancer. Methods A total 42 surgically treated patients with cavitating non-small cell lung cancer were studied retrospectively. Kaplan-Meiei was used to analyze the relationship between the prognostic factors and survival time. The cavitaing non-small cell lung cancer were matched 1:2 to the patients with non-small cell lung cancer that there is no cavity in X-ray, for gender, age, histology, lymph nodes dissection, stage, and whether receiving chemotherapy. The two groups were compared using the Log-rank test. Results The overall 1, 3, 5- year- survival rates for cavitating non-small cell lung cancer were 76.2%, 28.6%, and 14.7%, respectively. The diameter of the cavity and lymph nodes status significantly influenced syrvivals. 1he overall syrvival between the two groups of patients showed no sig- nificant differences (P=0.075). But the factors of women(P=O.040), younger than 60 years(P =0.032), NO of the lymph nodes dissection group(P=0.046), and staging Ⅰ were significantly influenced 5-year survivals(P=0.048). Conclusion The diameter of the cavity and lymph nodes status were correlated with the survival. The carcinomatous cavity are important prognosis factors for the nan-retail cell lung cancer patients of younger than 60 years, negative of lymph nodes dissection and staging Ⅰ , but whether the carci- nomtous cavity are important prognosis factors for the non-small cell lung cancer patients of woman was not determined.     

锁定钢板固定治疗肱骨近端骨折的临床疗效分析

目的:探讨锁定钢板固定治疗肱骨近端骨折的临床疗效,总结诊疗经验。方法:选取2010年3月～2012年12月某院收治行锁定钢板内固定治疗肱骨近端骨折患者34例,评价治疗效果。结果:平均随访(7.3±2.3)月,骨折均愈合,愈合时间3～5个月,平均(4.3±0.4)月;6个月后优秀19例(55.88%)、良好13例(38.24%),不同性别、年龄、Neer分级间疗效差异无统计学意义(P0.05)。结论:锁定钢板固定治疗肱骨近端骨折疗效显著,可有效促进骨折愈合,安全可靠。     

P27kipl及cyclinE在乳癌中的表达及相关性研究

目的研究p27kipl蛋白及cyclinE在乳癌中的表达水平以及影响p27kipl蛋白表达水平的因素.方法以免疫组化方法检测49例乳癌标本中p27kipl和cyclinE蛋白表达水平.结果49例乳癌标本中p27kipl蛋白(一)18例,占36.7%;(+)7例,占14.3%;(++)24例,占49%.阳性31例,阳性率63.3%,其蛋白表达水平与病理组织分级(P＜0.01).肿块大小(P＜0.05).淋巴结转移(P＜0.05)具有相关性,而与雌孕激素受体表达无关.cyclinE蛋白阳性19例,占38.8%.结论p27kipl蛋白在乳癌中的表达水平具有一定预后价值,对选择临床高危复发病例有一定意义.p27kipl与cyclinE蛋白表达水平在乳癌中未见相关性.