高血沉情况下C反应蛋白与白细胞计数之间相关性分析

目的：观察高血沉（ESR）情况下与C反应蛋白（CRP）与白细胞（WBC）计数之间相关性,并探讨CRP、ESR与WBC计数在呼吸系统感染及肾脏疾病中的临床应用价值。方法：检测高血沉情况下,呼吸系统感染及肾脏疾病患者血清的CRP水平、WBC计数,并进行统计分析。结果：高血沉情况下,CRP水平与WBC计数之间呈正相关关系（R=0．266）,呼吸系统感染患者血清CRP阳性率高于WBC计数阳性率,与肾脏疾病组相比有明显差别（P〈0．05）。结论：高血沉情况下CRP与WBC计数相关,CRP可作为提示呼吸系统感染的一个敏感指标。     

咪达唑仑对利多卡因致惊厥作用的影响

目的从致惊厥的行为学、安全性角度探讨咪达唑仑对利多卡因致惊厥作用的影响。方法皮下注射咪达唑仑20min后,腹腔注射不同剂量利多卡因,观察小鼠惊厥潜伏期、持续时间、未惊厥率及其死亡率;并按序贯法计算咪达唑仑对利多卡因致惊厥半数有效量（EDS0）和半数致死量（LD50）的影响。结果1．0mg／kg咪达唑仑可显著延长利多卡因致小鼠惊厥的潜伏期（P〈0．01）、显著缩短惊厥持续期（P〈0．01）、减少惊厥的发生;且2mg／kg、5mg／kg的咪达唑仑可减小利多卡因的LD50（P〈0．01）。结论1mg／kg咪达唑仑可拮抗利多卡因的致惊厥作用,结果对临床联合用药有一定的参考意义。     

2型糖尿病合并冠心病患者循环内皮细胞与CRP的关系及意义

目的:探讨2型糖尿病合并冠心病患者血清CRP与循环内皮细胞水平及两者的相关性。方法:以26例2型糖尿病合并冠心病患者为研究对象,以43例不合并糖尿病的冠心病患者和28例健康体检者为对照组,测定外周血循环内皮细胞数量及血清CRP水平。结果:2型糖尿病合并冠心病患者组CEC数量(8.3±2.4/0.9μl)和CRP水平(6.41±2.12 mg/L)明显高于冠心病组(7.2±3.1/0.9μl、4.63±1.88 mg/L)(P<0.01)和健康对照组(3.6±2.0/0.9μl、2.31±1.26 mg/L)(P<0.01)。2型糖尿病合并冠心病患者CEC数量和CRP水平呈正相关(r=0.682,P<0.01)。结论:2型糖尿病合并冠心病患者的血管内皮损伤可能与CEC及CRP有关,二者的协同作用可能在其微血管病变的发病机制中发挥重要作用。     

抑癌基因NPRL2的研究进展

抑癌基因NPRL2(nitrogen permease regulator-like 2)也称肿瘤抑制候选基因4(tumor suppressor candidate 4,TUSC4),定位于人染色体3p21.3区域,广泛存在于人体各种组织中,在生物物种之间具有高度保守性;研究发现,在人类多种肿瘤组织(如肺癌、乳腺癌和肾癌等)中的表达明显降低.NPRL2基因具有参与DNA错配修饰、调控细胞周期信号转导以及诱导细胞凋亡的生物学功能.NPRL2基因失活与多种肿瘤的发生和发展有关.但其具体的抑瘤机制尚不清楚,有待于进一步研究.     

聚丙烯网状材料与颈前皮瓣联合重建气管的实验研究

OBJECTIVE: Canine model established for tracheal defect reconstruction, to investigate the outcome of tracheal reconstruction with combination of polypropynene and flap. METHODS: About 3.5 to 4 centimeter cervical trachea was resected and replaced with artificial trachea made from monofilament knitted polypropylene and surgical flap. Covered stent was implanted postoperatively. Survival period and quality of life were recorded, bronchofibroscopy, X-ray films and HE sections were perfomed. RESULTS: Six dogs survived well and another two died. The causes of death were respiratory failure in 1 and infection in another. Stenosis of anastomosis in 1 was recorded during survival period. The dogs started drinking and eating on the second postoperative day, no dyspnea was found. The animals were sacrificed at 2, 4, 8 weeks and 6 months after surgery. Soft tissue growth was found in polypropynene net 2 weeks after surgery and more at 4 weeks. The polypropynene net was covered completely with soft tissue at 8 weeks and 6 months postoperatively, the hardness and sustentation degree were enhanced following the growth and fibrosis of soft tissue. The squamous epithelium and columnar epithelium were observed healing well by HE staining method. CONCLUSIONS: One-stage operative artificial trachea made from monofilament knitted polypropylene which has good histocompatibility and surgical flap is the closer artificial trachea to native trachea. It has a promising prospect in clinical use.     

医学检验专业学生临床实习中的新问题及教学思路

随着医学检验专业就业压力的增加,学生毕业实习与就业的矛盾在新形势下日益显现,对实习影响很大。本文就当前医院检验科带教工作中所遇见的问题和矛盾进行剖析,提出"拓宽就业视野、增强综合素质"的教学思路。     

基于CBL的多维度进阶式线上教学实践

疫情期间我校全面开展线上教学,对正常人体学课程进行创新性教学设计,实施基于CBL的多维度进阶式教学,从对知识的掌握、情感的体验和思维的训练等多个维度着手,引导学生开展生疑—引领—探索—思考与整理—记忆—实践—兴趣—情感体验步步进阶式学习.初步实践及研究表明该教学模式取得了较好效果,得到学生认可,提高了学习兴趣,锻炼...     

信息化系统在临床检验分析中的应用

近年来,随着基础医学和现代生物技术的快速发展,检验医学正朝着全实验室自动化系统（total laboratory automation,TLA）和信息化系统（laboratory information system, LIS）方向发展。信息化系统的应用能够为患者提供良好的医疗服务;有效地利用人力资源;缩短非技术性工作时间;提供实时自动查找检验结果;发挥检验分析仪的效能;提高管理信息的质量,产生准确、可靠和快速的工作量统计数据,并为医院建立费用预算提供数据参考。