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241.
慢性乙肝患者血清细胞因子、乙肝病毒与肝纤维化的关系 总被引:1,自引:0,他引:1
目的:探讨慢性乙肝患血清细胞因子(TGF-β,TNF-α,IL-6,IL-8),乙肝病毒(HBV)对肝纤维化(HA,PCⅢ,C-Ⅳ,LN)的影响作用。方法:采用ELISA和RIA方法检测171例慢性乙肝患血清TGF-β,TNF-α,IL-6,IL-8,HLA,PCǚ,C-Ⅳ,LN的水平,HBV-DNA定量检测采用PCR方法。结果:慢性乙肝患血清TGF-β,TNF-α,IL-6,IL-8,HA,PCⅢ,C-Ⅳ,LN的含量均不同程度高于对照组,且随肝损害程度的加重而升高,与肝损害程度呈正相关关系(P<0.05或P<0.01);须血清TGF-β1水平与血清HA,PCⅢ,C-Ⅳ,LN水平具有直线相关关系。HBV-DNA阳性组(Ⅱ组)均高于HBV-DNA阴性组(I组),且在慢性中,重度肝炎间差异显(P<0.05)。结论:血清TGF-β,TNF-α,IL-6,IL-8参与慢性乙肝的发病机制及肝纤维化的形成,且与病毒复制的活跃程度相关。 相似文献
242.
朱良保 《中国血吸虫病防治杂志》2006,18(2):82-82
自吡喹酮广泛应用于急、慢性血吸虫病治疗以来,其不良反应的报道日见增多,现报告致急性脱髓鞘脑病1例。1病例资料王某,女,38岁,湖南省湘阴县农民。有血吸虫疫水接触史,无自觉症状,血吸虫病普查时血清学间接血凝试验阳性。于2003年12月24日自行顿服购自当地血防部门的吡喹酮20片 相似文献
243.
Haiwei Wu Binhui Ren Jiaquan Zhu Guohua Dong Biao Xu Changtian Wang Xiaogang Zheng Hua Jing 《European journal of cardio-thoracic surgery》2006,29(6):902-907
Objective: Based on the findings that erythropoietin (EPO) has been proved to be a multiple functional cytokine to attenuate ischemia–reperfusion (I/R) injury in various organs such as brain, heart, and kidney in animals, this experiment was designed to evaluate the effect of pretreatment with recombined human erythropoietin (rhEPO) on I/R-induced lung injury. Methods: Left lungs of rats underwent 90 min of ischemia and then were reperfused for up to 2 h. Animals were randomly divided into three experimental groups as sham group, I/R group, and rhEPO + I/R group (a single dose of rhEPO was injected intraperitoneally 3000 U/kg 24 h prior to operation). Lung injury was evaluated according to semi-quantitive analysis of microscopic changes, tissue polymorphonuclear neutrophils (PMNs) accumulation (myeloperoxidase (MPO) activity), and pulmonary microvascular permeability (Evan's blue dying method). Peripheral arterial and venous blood samples were obtained for blood–gas analysis after 5 min occlusion of right lung hilus at the end of reperfusion. The serum concentration of tumor necrosis factor (TNF)- was also measured by the method of enzyme-linked immunosorbent assay. Results: Histological injury scoring revealed significantly lessened lung alveolus edema and neutrophils infiltration in the rhEPO pretreated group compared with I/R group (p < 0.05). The rhEPO pretreated animals exhibited markedly decreased lung microvascular permeability (p < 0.05) and myeloperoxidase activity (p < 0.05). Blood–gas analysis demonstrated that the pretreated animals had significantly ameliorated pulmonary oxygenation function (p < 0.05). The serum concentration of tumor necrosis factor- in rhEPO pretreated group was markedly decreased compared with that of I/R group (p < 0.05). Conclusions: Pretreatment with rhEPO appears to attenuate I/R-induced lung injury. This function is partly related with the capacity that rhEPO inhibits the accumulation of polymorphonuclear neutrophils in lung tissue and decreases the systematic expression of tumor necrosis factor-. 相似文献
244.
六味地黄冲剂对肾阴虚病人血浆中锌铜含量的影响 总被引:1,自引:0,他引:1
肾阴虚病人血浆中锌、铜含量均较正常人血浆中锌,铜含量明显增高(P<0.01)。男女性别间本组未见差异。服用治疗肾阴虚药物六味地黄3种剂型后均使锌,铜含量明显降低(P<0.01),六味地黄冲剂与汤剂效果一致。 相似文献
245.
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247.
Summary In this study the technique of labelling the cell membrane with DPH fluorescence polarization was used to observe the membrane
fluidity of B lymphocytic cell lines and tonsillar cells from healthy persons; the modulation effect on membrane-fluidity
induced by McAbs against isotypic and idiotypic determinants of IgM from patients with leukemia was studied as well. The expression
of the corresponding isotypic and idiotypic determinants of IgM on the cell membrane was determined. The results show that
the membrane fluidity of leukemic cell lines is remarkably higher than that of tonsillar cells from healthy persons, and McAbs
against isotypic determinants of leukemic IgM can enhance the membrane fluidity of all kinds of cells mentioned above. However,
the anti-idiotypic monoclonal antibody increased only the membrane fluidity of leukemic cell lines. These results indicated
that there was a close relationship between the effect of McAbs on cell membrane fluidity and the expression of corresponding
isotypic and idiotypic determinants of IgM on the cell membrane. 相似文献
248.
249.
人血浆中芬太尼的高效液相色谱测定方法 总被引:5,自引:1,他引:4
本文建立了测定人血浆中芬太尼的高效液相色谱方法,它具有线性范围宽,样品量小,灵敏度高,专一性强,操作简便等优点。它还可以分离和测定血浆中的奥芬太尼和苏芬太尼。适用于药代动力学的研究。 相似文献
250.