Efficacy of different irrigation agitation systems in the removal of root canal sealers from artificial standardised grooves

The present study aims to assess the efficacy of different irrigation agitation systems in removing calcium silicate-based sealers from artificial standardised apical grooves. After the root canal instrumentation of 96 teeth, artificial apical grooves were created in half of each root. The samples were divided into two main groups according to the sealer type (AH Plus Jet [APJ] and Sure-Seal Root™ [SSR]) (n = 48). The root halves were then reassembled and divided into four experimental groups based on the final irrigation technique used: Conventional Syringe Irrigation (CSI), Ultrasonic Irrigant Agitation (UIA), Sonic Agitation (SA) and Manual Dynamic Agitation (MDA). The roots were then dissembled to assess the amount of root canal sealer. UIA significantly removed more of SSR sealer than CSI, MDA and SA while there was no statistical difference between CSI, MDA, SA and UIA groups in the APJ group. None of the irrigation agitation systems used had completely removed the APJ and SSR sealers. However, UIA was more effective in removing SSR sealer from the standardised apical groove than were CSI, MDA and SA.     

埃克替尼联合放疗治疗晚期非小细胞肺癌的随机对照研究

目的 比较埃克替尼单药或联合胸部放疗治疗表皮生长因子受体（EGFR）敏感突变的Ⅳ期非小细胞肺癌的疗效及安全性。方法 共纳入83例EGFR基因敏感突变的晚期非小细胞肺癌患者,按随机数字表法分成两组。联合治疗组41例,肺部原发病灶放射治疗60~66 Gy,同步埃克替尼125 mg,3次/d,放疗结束后继续予埃克替尼维持治疗;单纯药物组42例,埃克替尼125 mg,3次/d。两组药物治疗直至疾病进展或出现不可耐受的不良反应后停止。研究的主要终点为中位无进展生存时间（mPFS）和12个月PFS率,次要终点为客观缓解率（ORR）、疾病控制率（DCR）和不良反应。结果 经过18.2个月的中位随访, 联合治疗组及单纯药物组mPFS分别为15.2个月（95%CI：12.2~17.4个月）及13.2个月（95%CI：10.8~14.9个月）（χ²=4.29,P=0.036）;1年PFS率分别为70.3%及61.2%;ORR分别为78.0%及57.1%（χ²=5.16,P=0.028）;DCR分别为95.1%及92.9%（P>0.05）。不良反应方面,常见的3~4级不良反应为皮疹,两组均为4例。联合治疗组中有10例发生1~2级放射性肺炎,15例发生1~2级放射性食管炎。结论 埃克替尼联合胸部放疗治疗EGFR敏感突变的晚期非小细胞肺癌可提高客观缓解率,延长无进展生存期,患者的不良反应耐受性良好。临床试验注册号 中国临床试验注册中心,Chi CTR-INR-16010262。     

抗炎口服液质量标准的研究

目的:建立抗炎口服液的质量标准。方法:采用TLC法对处方中的矮地茶、连翘进行鉴别;用固相萃取处理样品, RP-HPLC法测定连翘苷的含量。结果:在薄层色谱中能检出矮地茶、连翘;连翘苷在0．5～3．0μg线性关系良好,r=1．000 0, 平均回收率为98．2％,RSD为1．5％。结论:该方法准确可靠,能控制制剂的质量。     

用肾图定量分析法评价系统性红斑狼疮患者的肾脏损害

目的　探讨系统性红斑狼疮患者肾功能损害的敏感指标。方法　用 99m Tc-DTPA作示踪剂 ,对 5 8例患者进行常规肾显像 ,测定肾小球滤过率 ,并对肾图进行定量分析。结果　用 Gates法计算的肾小球滤过率与肌酐清除率有高度相关性。肾小球滤过率的改变与患病时间长短无关。本组中肾图异常者为5 0 % ,但肾图经定量分析后 ,半排时间、15分钟残余率的异常率分别为 93.1%和 85 .3% ,远较临床综合判断有 6 7.3%的患者肾功能受损为高。即使是肾小球滤过率在正常范围时 ,亦有 88.5 %的患者显示半排时间延长。此外 ,半排时间与 15分钟残余率对肾异常的检出率比尿素氮和 (或 )肌酐明显为高。结论　对肾图进行定量分析可提高其对肾脏功能损害判断的敏感性。     

Benign rheumatoid nodules of childhood

The nodules associated with rheumatoid arthritis and rheumatic fever appear with other signs of active rheumatic disease. Rheumatoid nodule-like lesions irrelevant to rheumatoid disease occasionally occur in children who are well and have no complaints associated with rheumatoid diseases. Laboratory tests are normal. Children with benign rheumatoid nodule are not at increased risk for rheumatic disease. No therapy or prophylaxis is required. We present a two-year-old girl with a subcutaneous nodule on the right pretibial region who was diagnosed with clinical and histological findings.     

The relationship of stabbing headaches with migraine attacks

Temporal and spatial relationships between idiopathic stabbing headache and migraine headache have so far been reported. We aimed to obtain some clues about the stabbing headache pathophysiology by comparing the two types of headache in regard to temporal and spatial relationships as well as precipitating and relieving factors of stabbing headache during migraine attacks. 43 patients who reported temporal relationship between migraine headache and stabs were studied. Localizations of migraine and stabbing headaches overlapped in 38 (88%) of the patients. 34 (79%) had stabs during migraine attacks, while 9 (21%) had stabs with a very close temporal relationship to migraine attacks. During the attacks, while head movements caused stabs in 10 patients (23%); applying pressure to the temples (n=3) and sleeping (n=2) alleviated or abolished stabs. We thought that stabs probably occur during a period in which central pain control mechanisms are weakened.     

Congenital dermoid cyst of the anterior fontanelle in Turkish children--four case reports

Four cases of congenital inclusion dermoid cysts located over the anterior fontanelle occurred in male Turkish children aged 6 months to 5 years. These rare cysts presented as slow-growing soft masses over the anterior fontanelle. The cysts were totally removed without recurrence. Dermoid cysts can be easily cured because of the absence of intracranial extension.     

晶状体蛋白质双向凝胶电泳的可重复性及分辨率研究

目的对晶状体蛋白质双向凝胶电泳进行可重复性及分辨率研究.方法用固相pH梯度等电聚焦(IPG-DALT)的方法,分别选用不同的上样量,10%或13%的SDS-聚丙烯酰胺凝胶电泳,用银染或考马斯亮蓝染色的方法对3个月新西兰兔的晶状体蛋白进行分离. 结果当上样量为150μg,13%的分离胶对晶状体蛋白(crystallin)的分离效果较好,当上样量为1.2mg,10%的分离胶对高相对分子质量蛋白的分离效果较好.凝胶点的匹配率为83.5%和 91.7%.结论用IPG-DALT的方法,综合小样本量和低密度凝胶电泳与大样本量高密度凝胶电泳结果,可以更好地分析晶状体蛋白的分离效果,但重复性还有待进一步提高.     

人免疫球蛋白联合甲泼尼龙治疗儿童重症肺炎的疗效评价

目的:探讨人免疫球蛋白在需甲泼尼龙(注射用甲泼尼龙琥珀酸钠)治疗的儿童重症肺炎的应用价值。方法:回顾性分析2021年1月至2022年6月在我院住院的重症肺炎患儿资料,选取其中使用了甲泼尼龙但未使用人免疫球蛋白辅助治疗的44例患儿为对照组,同时使用了甲泼尼龙和人免疫球蛋白辅助治疗的47例患儿为观察组,比较两组患儿的临床症状改善时间、治疗前后影像学、检验结果、疗效及不良反应发生情况。结果:观察组总有效率为91.49%,高于对照组的70.45%;临床症状改善时间短于对照组;治疗2周后肺部阴影吸收≥80%的患儿比例高于对照组;C反应蛋白(CRP)、白细胞(WBC)计数、降钙素原(PCT)等检验指标降低幅度大于对照组(P均<0.05)。两组患儿均无药物不良反应发生。结论:在甲泼尼龙辅助治疗的儿童重症肺炎同时应用人免疫球蛋白安全可行,可有效提高临床疗效。但考虑静脉用人免疫球蛋白属于血液制品,价格昂贵并存在用药风险,建议用药前与患者家属充分沟通,严格遵照用药指征选用。