全文获取类型
收费全文 | 5943篇 |
免费 | 308篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 96篇 |
儿科学 | 107篇 |
妇产科学 | 109篇 |
基础医学 | 749篇 |
口腔科学 | 702篇 |
临床医学 | 453篇 |
内科学 | 1160篇 |
皮肤病学 | 147篇 |
神经病学 | 310篇 |
特种医学 | 173篇 |
外科学 | 665篇 |
综合类 | 58篇 |
预防医学 | 823篇 |
眼科学 | 65篇 |
药学 | 424篇 |
中国医学 | 68篇 |
肿瘤学 | 205篇 |
出版年
2023年 | 82篇 |
2022年 | 184篇 |
2021年 | 306篇 |
2020年 | 213篇 |
2019年 | 238篇 |
2018年 | 276篇 |
2017年 | 188篇 |
2016年 | 195篇 |
2015年 | 260篇 |
2014年 | 346篇 |
2013年 | 392篇 |
2012年 | 384篇 |
2011年 | 500篇 |
2010年 | 290篇 |
2009年 | 234篇 |
2008年 | 269篇 |
2007年 | 296篇 |
2006年 | 256篇 |
2005年 | 206篇 |
2004年 | 169篇 |
2003年 | 161篇 |
2002年 | 132篇 |
2001年 | 85篇 |
2000年 | 71篇 |
1999年 | 64篇 |
1998年 | 41篇 |
1997年 | 42篇 |
1996年 | 32篇 |
1995年 | 19篇 |
1994年 | 25篇 |
1993年 | 18篇 |
1992年 | 26篇 |
1991年 | 28篇 |
1990年 | 16篇 |
1989年 | 28篇 |
1988年 | 30篇 |
1987年 | 14篇 |
1986年 | 20篇 |
1985年 | 18篇 |
1984年 | 13篇 |
1983年 | 9篇 |
1982年 | 9篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1976年 | 8篇 |
1971年 | 14篇 |
1970年 | 12篇 |
1969年 | 13篇 |
1968年 | 9篇 |
1967年 | 6篇 |
排序方式: 共有6314条查询结果,搜索用时 15 毫秒
91.
92.
José Aderval Aragão Maria Luisa Silveira Souto Carla Rocha São Mateus Liciane dos Santos Menezes Francisco Prado Reis 《Surgical and radiologic anatomy : SRA》2014,36(9):889-894
Purpose
The human mandible is subject to stimuli during its growth phase and also in adulthood. One of these stimuli may be absence of teeth, which gives rise to mandibular remodeling. Morphological changes may occur in different areas of this bone, such as in the gonial, condylar and ramus regions.Objective
To investigate the influence of edentulousness on remodeling of the gonial angle of the mandible and the angle formed by the mandibular incisure.Materials and method
Eighty-five dry mandibles from adults were examined: 42 from males and 43 from females. The mandibles were photographed using a camera coupled to a static support that was positioned 20 cm from the object to be photographed. The images were digitized and transferred to the Image J 1.42q software, in which the gonial angle of the mandible and the mandibular incisure angle were measured.Results
There were no differences in the mandibular and mandibular incisure angles in relation to presence or absence of teeth, or between the right and left sides. The mandibular incisure angle was greater in the women.Conclusion
Edentulousness did not cause remodeling of the gonial angle of the mandible or in the mandibular incisure angle. 相似文献93.
Luciana Ribeiro Serafim Jéssica Paôla Gonçalves da Silva Nívia Carolina Nogueira de Paiva Hudson Andrade dos Santos Maria da Gloria Quintão Silva Cláudia Martins Carneiro Sílvia Regina Costa Dias Élida Mara Leite Rabelo 《Parasitology research》2014,113(12):4611-4621
This study compared the course of Ancylostoma ceylanicum infection in hamsters infected with different inocula and the consequences for the host and helminth populations. The average of adult worms recovered, according to the number of third stage larva used, were 28.0, 24.8, 24.6, and 24.8 % to inocula size of 25 L3, 75 L3, 125 L3, and 250 L3, respectively. The size of the inoculum did not affect the establishment, survival, or fecundity of adult helminths. Reductions in the red blood cell and hemoglobin levels in the infected group were inversely proportional to the number of white blood cells. Moreover, differential cell counting revealed a positive correlation between the worm load and leucocyte numbers. The humoral response against excretion-secretion antigens was more robust and sensitive compared with the response against crude extract, with no direct linear correlation with the number of worms. The effect of the population density was more evident in females. 相似文献
94.
Tatiani Botelho Vinícius B. Marques Maylla R. Simes Patricia R. do Val Lima Fabiana V. Simes Dalton V. Vassallo Leonardo dos Santos 《Basic & clinical pharmacology & toxicology》2019,124(2):190-198
Mercury intoxication is a public health risk factor due to its hazardous effect to several organs, including the cardiovascular system. There is evidence of endothelial dysfunction after exposure to mercury, but the effects on endothelium‐dependent vasodilatation are still unknown. In the present study, we aimed to evaluate the chronic effects of high HgCl2 doses on the mechanisms of vasodilatation. Wistar rats were injected with HgCl2 (1st dose 10.86 μg/kg, and daily doses 0.014 μg/kg for 30 days i.m.), and saline was used as control. Mercury exposure reduced the acetylcholine‐induced vasodilatation in aortic rings, which was restored by incubation with antioxidant tiron. Inhibition of the NO synthase, Na+/K+‐ATPase and K+ channels indicates reduced participation of these factors. In the mercury group, there were an increased local anion superoxide and a reduced NO. The vasodilatation to exogenous NO was partially inhibited by co‐incubation with TEA plus tiron, suggesting that reduced NO bioavailability is the responsible to that decreased the participation of K+ channels. Moreover, there was an increased participation of the Na+/K+‐ATPase associated with an up‐regulation of its alpha‐1 subunit. In conclusion, reduced NO bioavailability plays a major role in the impaired participation of K+ channels and Na+/K+‐ATPase in the acetylcholine‐mediated relaxation, although sodium pump is up‐regulated probably as a compensatory mechanism. 相似文献
95.
Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano La la D Andrade Fernanda A Oliveira Monique CA Santos Cl udia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neog lia P de Almeida Jaciane AM Fontes r a M Pimentel Raquel Rocha Genoile Oliveira Santana 《World journal of gastroenterology : WJG》2020,26(44):6993-7004
BACKGROUNDThere has been an increase in cases of inflammatory bowel disease (IBD) in recent years. There is also greater access and availability of immunosuppressive and biological agents, which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing. Tuberculosis (TB) remains a public health problem, and it has a high incidence in several countries. Therefore, knowledge of the risk of developing TB in patients with IBD is important.AIMTo evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODSA standard questionnaire included demographic variables, clinical aspects of IBD disease, history of active TB during treatment, active TB characteristics and evolution, initial screening and results and time from the start of anti-tumor necrosis factor alpha (TNFα) to TB development.RESULTSAzathioprine, anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence. The TNFα blockers increased the relative risk of developing active TB compared to other treatments. All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB. After adjustment for sex, age, type of IBD and latent TB, anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment. Late TB, which was diagnosed 3 mo after the start of anti-TNFα, was the most frequent.CONCLUSIONTreatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America. This risk was increased when anti-TNFα was combined with azathioprine. The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. 相似文献
96.
Alberto Orocio-Carrillo José del Carmen Rivera-Cruz María Manuel Aranda-Ibañez Emilio Trujillo-Narcía Antonio Hernández-Galvez Geovanni Remedios Mendoza-López María 《Ecotoxicology (London, England)》2019,28(9):1063-1074
Ecotoxicology - The oil industry has inherent risks of spills or leaks due to natural or anthropogenic causes, which cause alterations in the soil and damage to the plant. An experiment was carried... 相似文献
97.
Tomy dos Santos Rolo Alexey Ershov Thomas van de Kamp Tilo Baumbach 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(11):3921-3926
Scientific cinematography using ultrafast optical imaging is a common tool to study motion. In opaque organisms or structures, X-ray radiography captures sequences of 2D projections to visualize morphological dynamics, but for many applications full four-dimensional (4D) spatiotemporal information is highly desirable. We introduce in vivo X-ray cine-tomography as a 4D imaging technique developed to study real-time dynamics in small living organisms with micrometer spatial resolution and subsecond time resolution. The method enables insights into the physiology of small animals by tracking the 4D morphological dynamics of minute anatomical features as demonstrated in this work by the analysis of fast-moving screw-and-nut–type weevil hip joints. The presented method can be applied to a broad range of biological specimens and biotechnological processes.The best method to study morphological changes of anatomic features and physiological processes is to observe their dynamics in 4D, that is, in real time and in 3D space. To achieve this we have developed in vivo X-ray cine-tomography to gain access to morphological dynamics with unrivaled 4D spatiotemporal resolution. This opens the way to a wide range of hitherto inaccessible, systematic investigations of small animals and biological internal processes such as breathing, circulation, digestion (1), reproduction, and locomotion (2).At the micrometer resolution range, state-of-the-art optical imaging techniques can achieve high magnifications to visualize tissues and even individual cells for 4D studies. These methods however are confined to transparent or fluorescent objects, or are limited either by low penetration depth <1 mm or poor time resolution (3). For optically opaque living organisms X-ray imaging methods are highly appropriate due to the penetrating ability of the radiation. Modern synchrotron radiation facilities provide brilliant and partially coherent radiation suitable for high-resolution volume imaging methods such as X-ray computed microtomography (SR-µCT). For static specimens SR-µCT has proven to be a powerful tool to study small animal morphology in 3D (4–6). The benefits of various physical contrast mechanisms, high spatial resolution, and short measuring times, as well as enormous sample throughput compared with laboratory X-ray setups, have led to its widespread use in life sciences.Real-time in vivo X-ray imaging with micrometer spatial resolution was realized so far by recording time sequences of 2D projection radiographs of different organisms (1, 6, 7), providing time information about functional dynamics but losing any information about the third spatial dimension.Recently, 4D in vivo X-ray experiments have been performed to study cell migration in frog embryos (8, 9) using tomographic sequences of a few seconds exposure time per tomogram interrupted by longer nonexposure time slots. In this way the authors followed relatively slow dynamics and morphological changes during embryonic development with 2-µm resolution over total time intervals of several hours. The fastest 4D time series yet reported were realized with a temporal resolution of 0.5 s and spatial resolution of 25 µm (10), applied to a living caterpillar used as test specimen for imaging, but without any analysis of dynamics.In this paper, we demonstrate the quantitative 4D investigation of morphological dynamics by in vivo X-ray 4D cine-tomography, introduced here as the combination of ultrafast SR-µCT and motion analysis procedures. Using this approach allows us to investigate previously inaccessible 3D morphological dynamics in small animals, presently with feature sizes in the micrometer range and with temporal resolution down to a few tens of milliseconds. In the past, ultrafast in vivo imaging was hardly possible for such applications, due to the strongly competing requirements for simultaneous high contrast, high signal-to-noise ratio (SNR), and concurrent low radiation dose, as well as the need for simultaneous high spatial resolution and maximum temporal resolution.In the following we describe how in vivo X-ray 4D cine-tomography meets the above challenges by optimizing image contrast, SNR, and spatial and temporal resolution in the ultrafast SR-µCT system and by establishing a dedicated data analysis pipeline, all within a unified framework (Fig. S1). We demonstrate the potential of the technique by investigating morphological dynamics in fast-moving weevils, focusing here on the exoskeletal joints. 相似文献
98.
99.