全文获取类型
收费全文 | 3726篇 |
免费 | 351篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 98篇 |
妇产科学 | 57篇 |
基础医学 | 425篇 |
口腔科学 | 372篇 |
临床医学 | 382篇 |
内科学 | 853篇 |
皮肤病学 | 161篇 |
神经病学 | 154篇 |
特种医学 | 180篇 |
外科学 | 481篇 |
综合类 | 106篇 |
现状与发展 | 30篇 |
一般理论 | 1篇 |
预防医学 | 376篇 |
眼科学 | 36篇 |
药学 | 169篇 |
中国医学 | 29篇 |
肿瘤学 | 135篇 |
出版年
2024年 | 23篇 |
2023年 | 205篇 |
2022年 | 73篇 |
2021年 | 114篇 |
2020年 | 128篇 |
2019年 | 109篇 |
2018年 | 154篇 |
2017年 | 118篇 |
2016年 | 119篇 |
2015年 | 143篇 |
2014年 | 194篇 |
2013年 | 203篇 |
2012年 | 272篇 |
2011年 | 263篇 |
2010年 | 181篇 |
2009年 | 189篇 |
2008年 | 170篇 |
2007年 | 187篇 |
2006年 | 134篇 |
2005年 | 107篇 |
2004年 | 89篇 |
2003年 | 86篇 |
2002年 | 67篇 |
2001年 | 41篇 |
2000年 | 59篇 |
1999年 | 54篇 |
1998年 | 45篇 |
1997年 | 53篇 |
1996年 | 47篇 |
1995年 | 42篇 |
1994年 | 33篇 |
1993年 | 38篇 |
1992年 | 21篇 |
1991年 | 20篇 |
1990年 | 23篇 |
1989年 | 26篇 |
1988年 | 31篇 |
1987年 | 23篇 |
1986年 | 10篇 |
1985年 | 24篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1982年 | 11篇 |
1981年 | 11篇 |
1980年 | 13篇 |
1979年 | 8篇 |
1976年 | 20篇 |
1975年 | 12篇 |
1974年 | 12篇 |
1965年 | 7篇 |
排序方式: 共有4099条查询结果,搜索用时 15 毫秒
21.
目的总结艾滋病患者在耳鼻咽喉的临床表现.方法10例艾滋病的临床资料回顾性分析.结果10例艾滋病患者,有卡波氏肉瘤8例,颈部肿块8例,皮肤、口腔咽喉黏膜溃疡4例,上呼吸道梗阻行气管切开术2例,单侧慢性化脓性中耳炎者1例.结论艾滋病患者以咽喉、口腔部卡波氏肉瘤及黏膜溃疡出现最早,应引起高度警惕及重视. 相似文献
22.
应用改进的眼震图检查先天性眼球震颤 总被引:2,自引:0,他引:2
目的评价改进后的眼震图对先天性眼球震颤波形的分析,为其手术治疗提供较为精确的量化标准.方法改进电生理仪的视网膜电图(EOG)程序,分别记录68例患者33cm原在位、右5°、10°、15°、20°,左5°、10°、15°、20°,3m原在位及闭眼的波形,并对其中28例手术患者术前和术后的眼震图进行比较.结果68例患者中,跳动型48例,其中水平跳动46例,垂直跳动2例;水平钟摆型20例.跳动型中,有代偿头位的40例,钟摆型无明显代偿头位.28例手术患者中,水平跳动型26例,水平钟摆型2例.26例跳动型患者均有中间位和代偿头位.术后20例代偿头位消失,6例代偿头位在左5°~10°.按震频、振幅、震强的分组中,处于中等震频、振幅、震强范围内的多见.结论改进的眼震图可以对眼震的振幅、震频、震强、中间位进行量化的检测,从而指导其治疗. 相似文献
23.
Zhang JD Cao YB Xu Z Sun HH An MM Yan L Chen HS Gao PH Wang Y Jia XM Jiang YY 《第二军医大学学报》2006,27(6):664-664
Antifungal activity of natural products is being studied widely. Saponins are known to be antifungal and antibacterial. We have isolated eight steroid saponins from Tribulus terrestris L. , namely TTS-8, TTS-9, TTS-10, TTS-11, TTS-12, TTS-13, TTS-14 and TTS-15. TTS-12 and TTS-15 were identified as tigogenin-3-O-β-D-xylopyranosyl(1→ 2)-[-β-D-xylopyranosyl( 1 → 3 ) 3-β- D-glucopyranosyl ( 1 → 4 )- 1- α-L-rhamnopyranosyl ( 1 → 2 ) 3-β-D-galactopyranoside and tigogenin-3-O-β-D-glucopyranpyranosyl(1→2)-[-β-D-xylopyranosyl(1→ 3)3-β-D-glucopyranosyl(1→4)-β-D-galactopyranoside, respectively. The in vitro antifungal activities of the eight saponins against six fluconazole-resistant yeasts, Candida albicans, Candida glabrata, Candida para psilosis , Candida tropicalis , Candida krusei , and Cryptococcus neo f ormans were studied using microbroth dilution assay. The results showed that TTS-12 and TTS-15 were very effective against several pathogenic candidal species and C. neoformans in vitro. It is noteworthy that TTS-12 and TTS-15 were very active against fluconazole-resistant C. albicans (MIC80 = 4.4, 9.4 mg/ml), C. neoformans (MIC80 =10.7, 18.7 mg/ml) and inherently resistant C. krusei (MIC80 =8.8, 18.4 mg/ml). So in vivo activity of TTS-12 in a vaginal infection model with fluconazole-resistant C. albicans was studied in particular. Our studies revealed TTS-12 also showed in vivo activities against fluconazole-resistant yeasts. In conclusion, steroid saponins TTS-12 and TTS-15 from Tribulus terrestris L. have significant in vitro antifungal activity against fluconazole-resistant fungi, especially TTS-12 also showed in vivo activity against fluconazole-resistant C. albicans. 相似文献
24.
25.
Konrath EL Neves BM Lunardi PS Passos Cdos S Simões-Pires A Ortega MG Gonçalves CA Cabrera JL Moreira JC Henriques AT 《Journal of ethnopharmacology》2012,139(1):58-67
Ethnopharmacological relevance
The study was aimed at evaluating medicinal and therapeutic potentials of two Lycopodiaceae species, Lycopodium clavatum (L.) and Lycopodium thyoides (Humb. & Bonpl. ex Willd), both used in South American folk medicine for central nervous system conditions. Alkaloid extracts were evaluated for chemical characterization, acetylcholinesterase and antioxidant activities.Materials and methods
The alkaloid extracts obtained by alkaline extraction were determined for each species by GC/MS examination. The evaluation of the anticholinesterase and the antioxidant activities of the extracts were tested by determining in vitro and ex vivo models. Effects on acetylcholinesterase (AChE) were tested in vitro using rat brain homogenates and ex vivo after a single administration (25, 10 and 1 mg/kg i.p.) of the alkaloid extracts in mice. The in vitro antioxidant effects were tested for the 2-deoxyribose degradation, nitric oxide (NO) interaction, 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity and total reactive antioxidant potential (TRAP). After an acute administration (25 and 10 mg/kg i.p.) of the extracts in middle-aged (12 months) mice, the antioxidant effects were estimated through the thiobarbituric acid reactive substances test (TBARS), and the antioxidant enzymes activities for catalase (CAT) and superoxide dismutase (SOD) were measured.Results
AChE activity was inhibited in vitro by the alkaloid-enriched extracts of both Lycopodium species in a dose and time-dependent manner in rat cortex, striatum and hippocampus. A significant inhibition was also observed in areas of the brain after acute administration of extracts, as well as decreased lipid peroxidation and increased CAT activity in the cortex, hippocampus and cerebellum. A moderate antioxidant activity was observed in vitro for the extracts. Chemically, the main alkaloids found for the two species were lycopodine and acetyldihidrolycopodine.Conclusion
This study showed that the biological properties of the folk medicinal plants Lycopodium clavatum and Lycopodium thyoides include AChE inhibitory activity and antioxidant effects, two possible mechanisms of action in Alzheimer's related processes. 相似文献26.
Digital health is the convergence of digital technologies with health, healthcare, living, and society. Contrasting with the slow trend during the last decades, in the last few years, we have observed an expansion and widespread adoption and implementation. In this paper, we revisit the potential that digital health presents for the delivery of higher quality, safer and more equitable care. Focussing on three examples – patient access to health records, big data analytics, and virtual care – we discuss the emerging opportunities and challenges of digital health, and how they can change primary care. We also reflect on the implications for research to evaluate digital interventions: the need to evaluate clear outcomes in light of the six dimensions of quality of care (patient-centredness, efficiency, effectiveness, safety, timeliness, and equity); to define clear populations to understand what works and for which patients; and to involve different stakeholders in the formulation and evaluation of the research questions. Finally, we share five wishes for the future of digital care in General Practice: the involvement of primary healthcare professionals and patients in the design and maintenance of digital solutions; improving infrastructure, support, and training; development of clear regulations and best practice standards; ensuring patient safety and privacy; and working towards more equitable digital solutions, that leave no one behind. 相似文献
27.
Romeika Lorena Mendes da Silva Tmara Taynah Medeiros da Silva Renata Lima Pessoa Ayane Cristine Alves Sarmento Kleyton Santos Medeiros Daniele Vieira Dantas Rodrigo Assis Neves Dantas 《Medicine》2022,101(24)
Introduction:Uterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Zingiber officinale contains bioactive compounds that act on pregnancy and postoperative nausea, chemotherapy-induced nausea and vomiting, and also in the management of fatigue, myalgia, and insomnia. This study aimed to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy.Methods and analyses:A randomized intervention clinical and controlled trial with a triple-blind design is described, comparing the effects of institutional antiemetic therapy alone, as well as in combination with 2 different ginger concentrations.Ethics and dissemination:Due to the nature of the study, we obtained approval from the Division Ethics Committee of Liga Contra o Câncer. All participants signed an informed consent form prior to randomization. The results of this study will be published in peer-reviewed journals. The data collected will also be available in a public repository of data.Trial registration number:This study is registered in the Brazilian Registry of Clinical Trials under number RBR-47yx6p9. This study was approved by the Division Ethics Committee of Liga Contra o Câncer under CAAE 40602320.0.0000.5293. 相似文献
28.
Dusse LM Carvalho Md Bragança WF Paiva SG Godoi LC Guimarães DA Fernandes AP 《European journal of obstetrics, gynecology, and reproductive biology》2007,134(1):20-23
OBJECTIVE: The aim of the present study was to compare the distribution of G1691A, G20210A and C677T mutations in pre-eclamptic Brazilian women and in matched control women with an uncomplicated normal pregnancy. STUDY DESIGN: these mutations were investigated by PCR-RFLP in 83 normal pregnancies (control group) and in 30 pre-eclamptic pregnant women (severe form). RESULTS: G1691A mutation was detected neither in the control group nor in pre-eclamsia women. G20210A mutation was detected in heterozygosis in 3 (3.61%) control subjects, but not in pre-eclampsia group. C677T mutation was detected in homozygosis in 6 (7.23%) control subjects and 2 (6.67%) pre-eclamptic women and in heterozygosis in 31 (37.3%) control subjects and 12 (40%) pre-eclamptic women. Differences in the mutation frequencies detected in the two groups were not statistically significant. CONCLUSION: No correlation was observed between pre-eclampsia and presence of G1691A, G20210A and C677T mutations in Brazilian women. 相似文献
29.
Dr. Azevedo Neves 《Journal of cancer research and clinical oncology》1908,7(1):180-183
Ohne Zusammenfassung 相似文献
30.
Ohne ZusammenfassungDiese. Arbeit ist ein Auszug aus dem Bericht, der von dem Autor der portugiesischen Kommission für Krebsforschung eingereicht wurde, eine Ergänzung des Aufsatzes des Verfassers auf S. 180 dieses Bandes der Zeitschrift. 相似文献