原发性头痛与焦虑抑郁障碍的相关性分析

目的 观察比较原发性头痛中偏头痛(migraine headache,MH),紧张性头痛(tension type headache,TTH),慢性头痛(chronic headache,CH)与焦虑抑郁情绪的相关性.方法 收集187例原发性头痛患者,将其筛选并分为偏头痛,紧张性头痛及慢性头痛组,结合汉密尔顿焦虑抑郁量表(hamilton anxiety and depression scale,HAMA and HAMD)分析各组与焦虑抑郁水平的相关性,并分析其共病情况.结果 原发性头痛各亚组均出现不同程度的焦虑,慢性头痛组与焦虑水平正相关性最高(P<0.001),其次为偏头痛组,最弱为紧张性头痛组,在慢性头痛组及偏头痛组出现与抑郁水平的正相关性(P<0.05),而在紧张性头痛未见明显相关性(P>0.05);原发性头痛各型均与焦虑抑郁存在共病关系.结论 焦虑抑郁情绪普遍存在与原发性头痛中,其中以慢性头痛与焦虑抑郁情绪相关性及共病关系最显著,这一结论对于我们的治疗有指导意义.     

原花青素对放射性心脏损伤大鼠血清cTn-Ⅰ、SOD、MDA、GSH-px的影响

目的:观察原花青素(proanthocyanidins)对放射性心脏损伤(radiation-induced heart damage,RIHD)大鼠血清肌钙蛋白Ⅰ(cardiac troponin Ⅰ,cTn-Ⅰ)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-px)表达水平的影响,以及对RIHD大鼠的可能作用及作用机制.方法:60只雄性远交群(sprague dawley,SD)大鼠,随机数字表法分为6组,每组10只,分别为正常对照组、单纯照射组、OPC小剂量(50 mg/kg)组、OPC中剂量(100 mg/kg)组、OPC大剂量(150 mg/kg)组、蓝莓(200 mg/kg)组.除正常对照组外,其余各组大鼠给予6MVX线单次大剂量照射心脏,总剂量(total dose,Dt)20 Gy,OPC组和蓝莓组大鼠给予相应药物灌胃.放疗结束后4周,HE染色、Masson染色观察大鼠心肌组织病理改变,ELISA检测血清cTn-Ⅰ、SOD、MDA、GSH-px表达水平.结果:与正常对照组比较,单纯照射组、OPC组、蓝莓组病理评分和心肌胶原容积分数(collagen volume fraction,CVF)评分升高(P＜0.05);与单纯照射组比较,OPC组、蓝莓组病理评分和CVF评分升高(P＜0.05),差异均具有统计学意义.与正常对照组相比,单纯照射组、OPC组、蓝莓组cTn-Ⅰ、MDA表达水平升高,单纯照射组、OPC组、蓝莓组SOD、GSH-px表达水平下降;与单纯照射组相比,OPC组、蓝莓组cTn-Ⅰ、MDA表达水平升高,OPC组、蓝莓组SOD、GSH-px表达水平下降,差异均具有统计学意义(P＜0.05).结论:OPC可通过抑制氧化应激,下调RIHD大鼠血清cTn-Ⅰ、MDA表达水平,上调血清SOD、GSH-px表达水平,抑制RIHD大鼠心肌损伤,疗效优于蓝莓.     

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.     

Linear and Interactive Effects of Air Pollution and Diurnal Temperature Range on COPD Mortality in Weifang,China: A Time Series Analysis

Chronic obstructive pulmonary disease (COPD), which is characterized by a long-term, irreversible airway limitation and persistent respiratory symptoms, is common and preventable. Several studies have suggested that particulate matter is associated with the prevalence of COPD and the risk of mortality. At the same time, the diurnal temperature?range?(DTR)?has?been?suggested?to?be an adverse health factor that is especially associated?with?an?increased?risk?of?hospitalization in patients with COPD[1]. DTR represents temperature variability within 1 day and is considered an important indicator of climate change.?A?few?studies?have?shown?that?ambient?air pollutants [particulate matter (PM)], such as PM2.5 and PM10, and high or low temperature have a synergistic effect on COPD[1]. Thus, the current study determined the interaction between particulate matter (PM) and the DTR on COPD mortality and identified the vulnerable population in?Weifang.     

甲硫氨酸合成酶基因A2756G多态性与2型糖尿病合并脑梗死的相关性

目的研究甲硫氨酸合成酶(MS)基因A2756G多态性与2型糖尿病合并脑梗死的相关性。方法采用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)方法鉴定安徽地区562例汉族人MS基因A2756G多态性基因型,比较对照组、2型糖尿病组、2型糖尿病合并脑梗死组各组间不同基因型及等位基因频率。结果安徽地区汉族人群存在MS基因A2756G多态性,其G等位基因频率与西方人群比较明显降低,2型糖尿病合并脑梗死组的MS不同基因型及等位基因频率与对照组比较,差异无显著性(P>0.05)。结论MS基因A2756G多态性与安徽地区汉族人群2型糖尿病合并脑梗死的遗传易感性无关。     

Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens

This study was conducted with objective of evaluating the toxic effects of nickel chloride (NiCl₂) on development of bursa of Fabricius in broilers fed on diets supplemented with 0, 300, 600 and 900 mg/kg of NiCl₂ for 42 days by using the methods of experimental pathology, flow cytometry (FCM), and quantitative real-time polymerase chain reaction (qRT-PCR). The results showed that dietary NiCl₂ in 300 mg/kg and over induced toxic suppression in the bursal development, which was characterized by decreasing lymphocytes histopathologically and relative weight, increasing G₀/G₁ phase (a prolonged nondividing state), reducing S phase (DNA replication) and proliferating index, and increasing percentages of apoptotic cells. Concurrently, the mRNA expression levels of bax, cytochrome c (cyt c), apoptotic peptidase activating factor 1 (Apaf-1), caspase-3, caspase-6, caspase-7 and caspase-9 were increased and the bcl-2 mRNA expression levels were decreased. The toxic suppression of bursal development finally impaired humoral immunity duo to the reduction of B lymphocyte population and B lymphocyte activity in the broiler chicken. This study provides new evidences for further studying the effect mechanism of Ni and Ni compoundson B-cell or bursa of Fabricius.     

Correlations of fascin-1 and cadherin-17 protein expression with clinicopathologic features and prognosis of patients with gastric cancer

Tumor Biology - We aim to explore the associations of fascin-1 and cadherin-17 in gastric cancer (GC) to the clinicopathologic features and prognosis of GC. Case group included 204 GC tissues while...