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排序方式: 共有826条查询结果,搜索用时 15 毫秒
31.
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 总被引:6,自引:0,他引:6
Dean F Wong Hiroto Kuwabara David J Schretlen Katherine R Bonson Yun Zhou Ayon Nandi James R Brasi? Alane S Kimes Marika A Maris Anil Kumar Carlo Contoreggi Jonathan Links Monique Ernst Olivier Rousset Stephen Zukin Anthony A Grace Jae Sung Lee Charles Rohde Donald R Jasinski Albert Gjedde Edythe D London 《Neuropsychopharmacology》2006,31(12):2716-2727
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine. 相似文献
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Immunological and functional protein S, protein C and antithrombin III levels and anticoagulant responses to activated protein C were measured in 24 patients with stroke in childhood. No hereditary deficiencies were found. The protein S levels in healthy controls of younger age did not differ from the adult levels. For optimal screening of protein S deficiency, measurements using functional as well as immunological assays are recommended. Appropriate criteria for the diagnosis of the deficiencies must be carefully applied if unnecessary anxiety and inappropriate treatment of children are to be avoided. 相似文献
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RICHARD LIVINGSTON RS VIRGINIA CRANE RN PA LEROY C. MIMS MD 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1977,6(6):7-10
There is disagreement among authors as to what criteria are most reliable in assessing postnatal fetal age. A comparison–for objectivity, accuracy, and frequency of use– of specific criteria was made using three independent examiners at different educational levels: a second-year medical student, a perinatal nurse practitioner, and a pediatrics resident. It was shown that trained examiners develop favorite criteria which differ among examiners and thus sacrifice accuracy; however, accurate assessment of fetal age can be accomplished by an examiner with minimum clinical knowledge. 相似文献
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FRITZI KALLOP RN RS 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1973,2(3):36-41
The author believes that professional advice given the parents of a mongoloid infant determines their initial decision on institutionalization. Multidisciplinary counseling by the health team can help parents decide on a course of action that will prove satisfactory in the long run. Consultation should include health t e r n efforts to help parents work through the mourning process and presentation of a) an objective, comprehensive view of the child's condition, b) information on integrating a mongoloid into the family unit, and c) outside resources available to the parents. Deliberation with the parents to help them reach their own decision is essential. 相似文献
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