全文获取类型
收费全文 | 490篇 |
免费 | 38篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 19篇 |
妇产科学 | 9篇 |
基础医学 | 71篇 |
口腔科学 | 12篇 |
临床医学 | 50篇 |
内科学 | 127篇 |
皮肤病学 | 14篇 |
神经病学 | 18篇 |
特种医学 | 81篇 |
外科学 | 40篇 |
综合类 | 9篇 |
预防医学 | 39篇 |
眼科学 | 1篇 |
药学 | 17篇 |
中国医学 | 2篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 5篇 |
2022年 | 7篇 |
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 8篇 |
2018年 | 14篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 3篇 |
2014年 | 9篇 |
2013年 | 28篇 |
2012年 | 19篇 |
2011年 | 17篇 |
2010年 | 27篇 |
2009年 | 24篇 |
2008年 | 6篇 |
2007年 | 13篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 13篇 |
2003年 | 15篇 |
2002年 | 9篇 |
2001年 | 12篇 |
2000年 | 10篇 |
1999年 | 15篇 |
1998年 | 17篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1994年 | 8篇 |
1993年 | 11篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1972年 | 3篇 |
1923年 | 2篇 |
排序方式: 共有530条查询结果,搜索用时 15 毫秒
71.
ARTHUR T.H. TAN BERNARD K.H. EE P.K. MAH MAURICE H.H. CHOO B.L. CHIA 《Pacing and clinical electrophysiology : PACE》1981,4(6):645-648
We report a case of familial sinus node disease with associated conduction abnormalities in the atrioventricular node and distal conduction system Spontaneous atrial pacemaker activity was absent though the atrium could be depolarized. The pacemaker activity of the heart resided in the atrioventricular junction. The AV node showed impaired automaticity and abnormal conduction properties which partially improved after vagal blockage. 相似文献
72.
H. S. Füeßl W. G. Zoller M. M. Kochen J. R. Bogner B. Heinrich A. Matuschke F. D. Goebel 《Journal of molecular medicine (Berlin, Germany)》1989,67(8):452-455
Summary We have observed two patients with AIDS suffering from severe watery diarrhea refractory to conventional medical treatment. In the first patient the reason for the diarrhea could not be revealed in spite of extensive investigations; however, the clinical picture suggested cryptosporidia infection. In the second patient cytomegalovirus could be shown in colonic biopsy specimens. After failure of several attempts of symptomatic, antibiotic, and antiviral therapy, the long-acting somatostatin analogue SMS 201-995 was administered to the patients subcutaneously in a dose between 2 × 50 µg and 3 × 100 µg/day. This treatment resulted in a prompt reduction of stool volume and bowel motions. Somatostatin may be a useful addition to the symptomatic treatment of refractory diarrhea in AIDS. 相似文献
73.
74.
75.
Individuals with impaired perforin-dependent cytotoxic function (Ctx(-)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx(-) lymphocytes, or enhanced antigen presentation. Whereas clinical and experimental data suggest that increased T-cell activation drives HLH, potential abnormalities of T-cell activation have not been well characterized in Ctx(-) hosts. To define such abnormalities and to test these hypotheses, we assessed in vivo T-cell activation kinetics and viral loads after lymphocytic choriomeningitis virus (LCMV) infection of Ctx(-) mice. We found that increased T-cell activation occurred early during infection of Ctx(-) mice, while they had viral burdens that were identical to those of WT animals, demonstrating that T-cell hyperactivation was independent of viral load. Furthermore, cell transfer and signaling studies indicated that increased antigenic stimulation, not a cell-intrinsic defect of responsiveness, underlay heightened T-cell activation in vivo. Finally, direct measurement of viral antigen presentation demonstrated an increase in Ctx(-) mice that was proportional to abnormal T-cell activation. We conclude that perforin-dependent cytotoxicity has an immunoregulatory role that is distinguishable from its pathogen clearance function and limits T-cell activation in the physiologic context by suppressing antigen presentation. 相似文献
76.
Keil S Müller M Zoller G Haschke G Schroeter K Glien M Ruf S Focken I Herling AW Schmoll D 《Journal of medicinal chemistry》2010,53(24):8679-8687
Acetyl CoA carboxylase isoforms 1 and 2 (ACC1/2) are key enzymes of fat utilization and their inhibition is considered to improve aspects of the metabolic syndrome. To identify pharmacological inhibitors of ACC1/2, a high throughput screen was performed which resulted in the identification of the lead compound 3 ( Gargazanli , G. ; Lardenois , P. ; Frost , J. ; George , P. Patent WO9855474 A1, 1998 ) as a moderate selective ACC2 inhibitor. Optimization of 3 led to 4m ( Zoller , G. ; Schmoll , D. ; Mueller , M. ; Haschke , G. ; Focken , I. Patent WO2010003624 A2, 2010 ) as a submicromolar dual ACC1/2 inhibitor of the rat and human isoforms. 4m possessed favorable pharmacokinetic parameters. This compound stimulated fat oxidation in vivo and reduced plasma triglyceride levels in a rodent model after subchronic administration. 4m is a suitable tool compound for the elucidation of the pharmacological potential of ACC1/2 inhibition. 相似文献
77.
Objective
To investigate the association between the three anatomical factors of Q-angle (QA), pelvic width (PW) and Intercondylar notch width (INW) and knee injuries among the U-23 female soccer players of South AfricaMethods
The study is a case-control prospective study design. Twenty four U-23 women soccer players of the South African team were purposively chosen to participate in this study. Participants were divided into two groups: group1 (Case) was those with knee injuries, while those without injuries were in group-2 (Control). PW and INW were measured after X-rays of the hip were taken while the QA was measured manually with the goniomenter. Association between anatomical factors and knee injuries were tested with ANOVA.Results
Q-angle ranged from 14° to 18° for both injured and non injured groups. PW was between 24 –29 cm for both injured and non injured groups. INW was between 1.3mm and 2.8mm for the right and between 1.4mm and 2.5mm for the left notch for the injured group, while INW for the right and left of the non injured group were between 1.7mm to 2.1mm and 1.8mm to 2.1mm, respectively No significant association between knee injuries and each of the anatomical factors was found QA (p= 0.74), PW (p=0.34), INW (right and left respectively) (p=0.142 & p=0.089).Conclusion
The three anatomical factors of QA, PW and INW could not be used to predict knee injuries amongst the U-23 female players in South Africa. 相似文献78.
79.
Excellent post‐transplant survival in patients with intermediate stage hepatocellular carcinoma responding to neoadjuvant therapy 下载免费PDF全文
Armin Finkenstedt Anja Vikoler Manuela Portenkirchner Kerstin Mülleder Manuel Maglione Christian Margreiter Patrizia Moser Wolfgang Vogel Reto Bale Martin Freund Anna Luger Herbert Tilg Johannes Petersen Stefan Schneeberger Ivo Graziadei Heinz Zoller Bernhard Glodny 《Liver international》2016,36(5):688-695