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排序方式: 共有530条查询结果,搜索用时 15 毫秒
61.
Julia Dietz Velia Chiara Di Maio Adolfo de Salazar Dolores Merino Johannes Vermehren Stefania Paolucci Andreas E. Kremer Magdalena Lara Maria Rodriguez Pardo Heinz Zoller Elisabetta Degasperi Kai-Henrik Peiffer Laura Sighinolfi Francisco Téllez Christiana Graf Valeria Ghisetti Jonas Schreiber Elisa Fernández-Fuertes Wolfgang Schmidt 《Journal of hepatology》2021,74(4):801-810
62.
Graziadei IW Zoller HM Schloegl A Nachbaur K Pfeiffer KP Mark W Mikuz G Pratschke J Margreiter R Vogel W 《Liver transplantation》2012,18(6):671-679
There have been few detailed studies of viral kinetics after liver transplantation (LT), and conflicting data have been reported on viral loads and the severity of recurrent hepatitis C virus (HCV) disease. This long-term study aimed to examine (1) the impact of HCV RNA levels at specific points in time within the first year and (2) the influence of interleukin-28B (IL-28B) genotypes on patient outcomes and the severity of recurrent HCV disease. The viral loads were measured 2, 4, 12, 24, and 48 weeks after LT, and the recipient/donor IL-28B genotypes of 164 patients were determined. A Cox regression analysis showed that the viral load at week 2 was an independent negative predictor of recipient outcomes. A week 2 viral load ≥ 6.0 log(10) IU/mL was significantly associated with reduced patient survival. After a mean follow-up of 6.5 years, 21 of 164 patients (12.8%) developed a cholestatic type of HCV recurrence and/or rapidly progressed to cirrhosis within 1 year. A multivariate binary regression analysis showed that HCV viremia at week 2 and a non-C/C recipient IL-28B genotype were independent risk factors for cholestatic recurrent HCV. No predictive factors could be found for the occurrence of recurrent liver cirrhosis 5 and 10 years after LT. Our study shows that the HCV RNA level at week 2 and the recipient IL-28B genotype are independent, statistically significant risk factors for post-LT cholestatic HCV, and it emphasizes the importance of viral load monitoring and IL-28B genotyping for identifying HCV recipients at risk for severe HCV recurrence. 相似文献
63.
ObjectiveTo determine the knowledge of HIV/AIDS among primary school pupils in north central area of Nigeria.Methods2000 randomly selected primary school pupils in and around eastern part of Idoma area of Benue state were interviewed using an open-ended questionnaire. Data analysis was done with EPI-INFO 2000. The Chi-square test was used for statistical analysis and the 0.05 level of significance was adopted.ResultsA totle of 1010 males and 990 females at ages between five and sixteen years were drawn from 10 primary schools in the area. Pupils in the higher classes were more knowledgeable and sex difference was not statistically significant. Certain misconceptions were noted.ConclusionsThere is need for health education for all cadres of primary school pupils in the area, which will increase the awareness of the disease. 相似文献
64.
Inhibition and potentiation of platelet function by lysolecithin 总被引:1,自引:0,他引:1
65.
Type III protein S deficiency is characterized by a low plasma level of free protein S, whereas the total concentration of protein S is normal. In contrast, both free and total protein S levels are low in type I deficiency. To elucidate the molecular mechanism behind the selective deficiency of free protein S in type III deficiency, the relationship between the plasma concentrations of beta-chain containing isoforms of C4b-binding protein (C4BP beta+) and different forms of protein S (free, bound, and total) was evaluated in 327 members of 18 protein S- deficient families. In normal relatives (n = 190), protein S correlated well with C4BP beta+, with free protein S (96 +/- 23 nmol/L) being equal to the molar excess of protein S (355 +/- 65 nmol/L) over C4BP beta+ (275 +/- 47 nmol/L). In protein S-deficient family members (n = 117), the equimolar relationship between protein S (215 +/- 50 nmol/L) and C4BP beta+ (228 +/- 51 nmol/L), together with the high affinity of the interaction, resulted in low levels of free protein S (16 +/- 10 nmol/L). Free protein S levels were distinctly low in protein S- deficient members, whereas in 47 of the protein S-deficient individuals, the concentration of total protein S was within the normal range, which fulfils the criteria for type III deficiency. The remaining 70 had low levels of both total and free protein S and, accordingly, would be type I deficient. Coexistence of type I and type III deficiency was found in 14 families, suggesting the two types of protein S deficiency to be phenotypic variants of the same genetic disease. Interestingly, not only protein S but also C4BP beta+ levels were decreased in orally anticoagulated controls and even more so in anticoagulated protein S-deficient members, suggesting that the concentration of C4BP beta+ is influenced by that of protein S. In conclusion, our results indicate that type I and type III deficiencies are phenotypic variants of the same genetic disease and that the low plasma concentrations of free protein S in both types are the result of an equimolar relationship between protein S and C4BP beta+. 相似文献
66.
Karl Heinz Weiss Florentine Thurik Daniel Nils Gotthardt Mark Schäfer Ulrike Teufel Franziska Wiegand Uta Merle Daniela Ferenci–Foerster Andreas Maieron Rudolf Stauber Heinz Zoller Hartmut H. Schmidt Ulrike Reuner Harald Hefter Jean Marc Trocello Roderick H.J. Houwen Peter Ferenci Wolfgang Stremmel 《Clinical gastroenterology and hepatology》2013,11(8):1028-1035.e2
67.
68.
69.
W. G. Zoller C. Wierscher D. R. Wagner 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1993,193(1):105-115
Using a new flow-test phantom, which respects the acoustic properties of real blood as well as the proximal and distal impedances
of body circulation, we assessed the performance of two duplex sonography signal processors on blood-flow measurements. With
both the analog and the dynamic signal processor (Fast Fourier Transform), the correlation between duplex sonography and quantitative
flow measurements was high (0.96–0.99) for different dynamic conditions (steady or pulsatile blood flow, varying heart rate,
blood pressure, and hematocrit) and for different mechanical conditions (silicon tube or animal vessel). The real blood flow
was overestimated by duplex sonography the over-estimation was more pronounced with the analog processor (factor 1.87–4.20)
than with the digital processor (factor 1.22–1.64,P<0.05). Applied to the study of asymmetric stenoses, the digital processor was not superior to the analog processors described
in the literature. 相似文献
70.
Visibility of gallstone fragments at US and fluoroscopy: implications for monitoring gallstone lithotripsy 总被引:1,自引:0,他引:1
To assess the value of ultrasound (US), fluoroscopy, and spot radiography in the detection, counting, and measurement of gallstone fragments during lithotripsy, in vitro visibility studies were conducted on fragments from 20 stones. Fluoroscopic visibility was evaluated during and after lithotripsy on 185 fragments placed in an anthropomorphic phantom. Three US experiments were performed on the fragments to study the visibility of fragments as a function of size, the accuracy of the count with large numbers of fragments, and the ability of observers to detect and count fragments larger than both 4 mm and 5 mm. With fluoroscopy, fragment detection rates ranged from 20% (fragments larger than 2.5 mm) to 80% (fragments larger than 4.5 mm). With US, all fragments larger than 1.5 mm were detected, and US was significantly better than fluoroscopy and spot radiography for detection of fragments 2.5 mm or smaller. US was also more accurate than fluoroscopy (11% vs 59% error) in the assessment of the number of fragments. When fragments larger than 4 mm or 5 mm were being counted with US, 92% of the fragments were visualized. The results suggest that US is more accurate for monitoring gallstone lithotripsy than fluoroscopy or spot radiography. 相似文献