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51.
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Prados MD Schold SC JR SC Fine HA Jaeckle K Hochberg F Mechtler L Fetell MR Phuphanich S Feun L Janus TJ Ford K Graney W 《Neuro-oncology》2003,5(2):96-103
RMP-7, a bradykinin analog, temporarily increases the permeability of the blood-brain tumor barrier to chemotherapy drugs like carboplatin. We conducted a randomized, controlled trial of carboplatin and RMP-7 versus carboplatin and placebo in patients with recurrent malignant glioma. The primary outcome measure was time to tumor progression (TTP). Adults with recurrent glioblastoma multiforme or anaplastic glioma were randomized in a 1:1 ratio to receive carboplatin and either RMP-7 or placebo. Radiation therapy had failed in all patients, and they may have received prior chemotherapy. Carboplatin (dosed to achieve an area under the curve of 5 mg/ml x time for patients who had received prior chemotherapy, or 7 mg/ml x time for those who had not) was given intravenously every 4 weeks, followed by intravenous infusion of either RMP-7 or placebo (300 ng/kg). TTP, tumor response, neuropsychological assessments, functional independence, and quality of life assessments were analyzed every 4 weeks. There were 122 patients enrolled, 62 in the RMP-7 and carboplatin group and 60 in the placebo and carboplatin group. Median TTP was 9.7 weeks (95% CI, 8.3-12.6 weeks) for the RMP-7 and carboplatin group and 8.0 weeks (95% CI, 7.4-12.6 weeks) for the placebo and carboplatin group. Median survival times were 26.9 weeks (95% CI, 21.3-37.6 weeks) for the RMP-7 group and 19.9 weeks (95% CI, 15.0-31.3 weeks) for the placebo group. No differences were noted for time to worsening of neuropsychological assessments, functional independence, or quality of life assessments. The use of RMP-7 had no effect on the pharmacokinetics or toxicity of carboplatin. At the dose and schedule used in this trial, RMP-7 did not improve the efficacy of carboplatin. Recent preclinical pharmacokinetic modeling of RMP-7 suggests that higher doses of RMP-7 may be required to increase carboplatin delivery to tumor. 相似文献
53.
Butler MW Mullan RH Schaffer KE Crotty TB Luke DA Donnelly SC 《Irish journal of medical science》2003,172(4):204-205
Background Hydatid disease is rare in Ireland and its incidence and prevalence are unknown. Most cases are diagnosed by a combination
of clinical findings, morphological features on imaging and by serological testing.
Aims We describe an Irish case of pulmonary hydatid disease detected at bronchoscopy by bronchoalveolar lavage, and discuss the
diagnosis and treatment of the disorder. 相似文献
54.
A history of pet contact and/or apparent clinical sensitivity was obtained in 65 (55%) of 118 unselected asthmatic children. These 65 children were skin tested and their sera examined for specific IgE using the radioallergosorbent test. Those children who had apparent clinical sensitivities had larger skin test reactions and were more likely to have positive specific IgE results than those without apparent sensitivities. Positive skin tests were very common (80%), but the larger the skin test reaction (weal diameter greater than 4 mm diameter) the more likely was there to be a positive history or a positive specific IgE result. Hence a large skin test reaction can provide a helpful pointer to animal allergy of clinical importance. Commercially available animal extracts have limitations for diagnostic tests. A questionnaire survey of 150 day schools emphasized the potential opportunities for contact with animal allergens at school. 相似文献
55.
闭合性输尿管损伤的早期诊断 总被引:1,自引:1,他引:0
0 引言 腹部钝性伤所致闭合性输尿管损伤罕见,且早期缺乏典型症状,往往延误诊断[1],造成严重后果.我们采用电视屏幕动态观察下大剂量静脉肾盂造影或逆行造影的方法,早期诊断闭合性输尿管损伤,取得较满意效果.1 临床资料 本组男性5例,女性1例,年龄3岁~36岁,右侧4例,左侧2例.2例合并肾损伤,1例合并骨盆骨折,右骶髂关节分离,尿道损伤.4例为撞伤、压伤,2例坠落伤.6例均无典型输尿管损伤症状.4例在电视屏幕动态观察下行大剂量静脉肾盂造影,其中1例同时在电视屏幕动态观察下行逆行造影.本组6例,早… 相似文献
56.
BDSS Budagoda KAS Kodikara WKS Kularatne RM Mudiyanse DH Edussuriya JP Edirisinghe IP Karunaratne KGAD Weerakoon SC Medagedara SAM Kularatne 《Asian Pacific journal of tropical medicine》2010,3(7):586-588
The sting of Giant Asian honeybee (Apis dorsata) or Bambara in Sinhala and Karunge Kulavi in Tamil is a common environmental hazard in Sri Lanka known to cause immediate allergic reactions, which could be fatal in sensitized individuals. We reported myocardial infarction, bowel gangrene and fatal anaphylaxis in a prospectively proven case series and the association of these uncommon complications with delayed removal of stingers from the patients' skin. 相似文献
57.
K-Ⅱ系k阿片激动剂U-50488的同类物。通过部分离体和整体实验比较了K-Ⅱ与U-50488的药理作用。实验发现,K-Ⅱ抑制电刺激兔输精管收缩的IC50值为0.42 nmol/L,U-50488为26.5 nmol/L;K-Ⅱ抑制小鼠运动功能(横筛法)的ED50值为1.7 mg/g,U-50488为15.3 mg/kg;K-Ⅱ的小鼠LD50值为152.5 mg/kg,U-50488为118.4 mg/g;K-Ⅱ明显降低小鼠自发活动的作用比U-50488强5倍。结果表明,K-Ⅱ是一个药理作用较U-50488强的k受体激动剂。 相似文献
58.
Roelof Risselada Hester F Lingsma Andrew J Molyneux Richard SC Kerr Julia Yarnold Mary Sneade Ewout W Steyerberg Miriam CJM Sturkenboom 《BMC medical research methodology》2010,10(1):86
Background
Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating event with a frequently disabling outcome. Our aim was to develop a prognostic model to predict an ordinal clinical outcome at two months in patients with aSAH. 相似文献59.
60.