Axitinib is a potent vascular endothelial growth factor receptor (VEGFR) inhibitor, which has a strong inhibitory effect on the three isoforms of VEGFR 1–3. Having strong therapeutic efficacy, its broad use is limited by its side effects such as hypertension, proteinuria, cardiovascular damage, and liver and kidney dysfunction. Selenium compounds are broadly reported to have a good protective effect on cardiovascular disease, inflammation, infection, and immune function. In this study, a selenium substitute of axitinib was synthesized, and its anti-renal cell carcinoma activity and side effects were investigated. The results of the study indicated that Se-axitinib had potent antitumor activity on renal cell carcinoma (RCC), alleviated vascular hyperpermeability, and also alleviated axitinib-related side effects including hypertension, liver dysfunction and kidney dysfunction significantly. Therefore, we suggest that Se-axitinib could be a solution to the severe side effects of VEGFR inhibitors and provide evidence to improve the outcome of RCC treatment.Se-axitinib is a selenium substitution of sulfur in axitinib, which reduced the side effect of VEGFR inhibitors and maintained the potent anticancer activity of the original drug. 相似文献
The rGO/CeO2/FTO nanocomposite modified electrode was prepared by an electrochemical method. A simple and highly sensitive electrochemical sensing platform for electrochemical rGO and modified CeO2 nanoribbons directly on FTO electrodes was developed. Simultaneous determination of Pb2+ and Cd2+ used the differential pulse anodic stripping voltammetry (DPASV) method. The method was simple to operate, and CeO2 nanobelts could be obtained simultaneously by electrodeposition and reduction of GO without further processing. This is an environmentally friendly electrochemical method to obtain modified electrodes under mild conditions. The experimental results showed that the linear calibration curves of Pb2+ and Cd2+ are 1–300 and 0.2–500 μg L−1, respectively. At the same time, no interference from other coexisting metal ions was found during the detection process, which proved that the modified electrode had good stability and repeatability.The rGO/CeO2/FTO nanocomposite modified electrode was prepared by an electrochemical method.相似文献
Aqueous rechargeable lithium-ion batteries (ARLBs) are regarded as a competitive challenger for large-scale energy storage systems because of their high safety, modest cost, and green nature. A kind of modified composite material composed of H2V3O8 nanorods and graphene sheets (HVO/G) has been effectively made by a one-step hydrothermal method and following calcination at 523 K. XRD, SEM, TEM, and TG are used to determine the phase structures and morphologies of the composite materials. Owing to the advantage of the layered structure of H2V3O8 nanorods, the excellent conductivity of the graphene sheets, and the 3D network structure of the modified composite, the ARLBs with HVO/G can deliver an adequate specific capacity of 271 mA h g−1 at 200 mA g−1 and have a retention rate of 73.4% after 50 cycles. The average discharge capacity of ARLB with HVO/G as anode has a considerable improvement over that of HVO/CNTs and HVO, whatever the current rate used. Moreover, we find that the diffusion coefficient of lithium-ion increases by an order of magnitude through the theoretical calculation for HVO/G ARLB. The new ARLB with HVO/G electrode is a potential energy storage system with great advantages, such as simple preparation, easy assembly process, excellent safety and low-cost environmental protection.Aqueous rechargeable lithium-ion batteries (ARLBs) are regarded as a competitive challenger for large-scale energy storage systems because of their high safety, modest cost, and green nature.相似文献
The introduction of ‘defects’ to the thermoset crosslinking network is one of the most applicable strategies for improving the modulus and toughness simultaneously. However, the reinforcement effect disappears when the ‘defects’ proportion exceeds the threshold. The speculated mechanism was that the aggregation and entanglement of the ‘defects’ chains changed the matrix topology, making the stacking structure more compact. However, the ‘defects’ are hardly directly observed in the experiment. As the result, the relationship between the ‘defects’ proportion and the package state of the matrix, and the effect on the material''s mechanical performance was not explored. Herein, the network of bisphenol-A diglycidyl (DGEBA) with diethyltoluenediamine (DETDA) as the hardener was constructed using MD simulation, and n-butylamine was decorated on the matrix by replacing a proportion of DETDA acting as the ‘defects’. The results indicated that the aliphatic chains aggregated and entangled at a low concentration, occupying the voids in the rigid aromatic crosslinking structure, thus lowering the free volume. The strong non-bonding interactions drew the matrix segments close together, thus reinforcing the resin. However, the microphases formed by the aliphatic chains no longer filled the voids but created a new free volume and loosened the network when the content increased, which reduced the mechanical performance of the material. The experimental results were consistent with the findings in the simulations. The moduli of the resin increased with the increase in the n-butylamine content first and then declined. The maximum moduli of the thermosets was 3.4 GPa in S30, which was about 25% higher compared with the control; the corresponding elongation at break was 8.9%, which was about 46% improved compared with the control.The introduction of ‘defects’ to the thermoset crosslinking network is one of the most applicable strategies for improving the modulus and toughness simultaneously.相似文献
Efficient catalysts for the electroreduction of N2 to NH3 are of paramount importance for sustainable ammonia production. Recently, it was reported that NbSe2 nanosheets exhibit an excellent catalytic activity for nitrogen reduction under ambient conditions. However, existing theoretical calculations suggested an overpotential over 3.0 V, which is too high to interpret the experimental observations. To reveal the underlying mechanism of the high catalytic activity, in this work, we assessed NbSe2 edges with different chirality and Se vacancies by using first principles calculations. Our results show that N2 can be efficiently reduced to NH3 on a pristine zigzag edge via the enzymatic pathway with an overpotential of 0.45 V. Electronic structure analysis demonstrates that the N2 molecule is activated by the back-donation mechanism. The efficient tuning of the local chemical environments by edge chirality provides a promising approach for catalyst design.The zigzag edge of the NbSe2 monolayer exhibits an overpotential as low as 0.45 V along the enzymatic pathway.相似文献
Accurate methods for identifying pelvic lymph node metastasis(LNM)of prostate cancer(PCa)prior to surgery are still lacking.We aimed to investigate the predicti... 相似文献