外科清创联合VSD治疗急性创面的效果观察

目的 探讨外科清创联合负压封闭引流(VSD)治疗急性创面的效果.方法 选取2018年5月至2020年5月本院收治的60例急性创面患者为研究对象,按照随机数字表法分为两组,各30例.B组给予外科清创+常规换药治疗,A组在B组基础上联合VSD治疗.比较两组患者治疗情况(创面面积、住院时间、应用抗生素费用、换药次数、创面Ⅱ期...     

Detection of noisy rectangular targets in high spatial resolution images

Human-related targets in high-spatial-resolution images often present rectangular shapes, such as most buildings, farmland, etc. However, their edges often encounter bending or missing parts as well as redundancy, making them difficult to detect by current breaking-assembling strategies that initially detect line segments and then gather them into potential rectangles. We propose a rectangle-detection method that uses a whole-object detection strategy that detects rectangles as integrated units to avoid these problems. Comparison experiments with a state-of-the-art method on both synthesized and high-spatial-resolution images indicate that our method performs well in detecting rectangles both in accuracy and time-cost aspects, especially when the edges are noisy.     

培菲康联合马来酸曲美布丁早期治疗对脓毒症患者肠黏膜屏障功能的影响

目的探讨培菲康联合马来酸曲美布丁早期治疗对脓毒症患者肠黏膜屏障功能的影响。方法将92例入住综合性ICU未出现肠功能障碍的脓毒症患者随机分成治疗组和对照组,每组46例。治疗组有4例及对照组有5例因不符合病例研究标准,最终被剔除本研究。除接受基础治疗外,治疗组患者入组第1天开始,鼻饲或者口服培菲康及马来酸曲美布丁,连用7 d以上,对照组则给生理盐水。采用酶联免疫吸附法(ELISA法)测定治疗前及第3、5、7天血浆二胺氧化酶(DAO)活性及D-乳酸浓度。在治疗后第5、7天评定2组肠功能。结果治疗前2组患者DAO活性及D-乳酸浓度比较差异均无统计学意义(t=0.802 9、0.340 3,P>0.05),治疗第7天,治疗组DAO活性及D-乳酸浓度均低于对照组(t=7.560 8、5.502 3,P<0.05)。2组组内比较,治疗前DAO活性及D-乳酸浓度最高,随着时间的推移,2项指标均逐渐下降(P<0.01,P<0.05)。治疗后第5、7天,治疗组肠功能评分均低于对照组[(0.485±0.312)分vs.(0.634±0.363)分;(0.216±0.354)分vs.(0.425±0.367)分,P<0.05]。而组内比较,2组第7天肠功能评分均低于第5天(P<0.05)。结论培菲康联合马来酸曲美布丁早期治疗有助于保护脓毒症患者肠黏膜屏障功能。     

Strawberry Phytochemicals Inhibit Azoxymethane/Dextran Sodium Sulfate-Induced Colorectal Carcinogenesis in Crj: CD-1 Mice

Human and experimental colon carcinogenesis are enhanced by a pro-inflammatory microenvironment. Pharmacologically driven chemopreventive agents and dietary variables are hypothesized to have future roles in the prevention of colon cancer by targeting these processes. The current study was designed to determine the ability of dietary lyophilized strawberries to inhibit inflammation-promoted colon carcinogenesis in a preclinical animal model. Mice were given a single i.p. injection of azoxymethane (10 mg kg⁻¹ body weight). One week after injection, mice were administered 2% (w/v) dextran sodium sulfate in drinking water for seven days and then an experimental diet containing chemically characterized lyophilized strawberries for the duration of the bioassay. Mice fed control diet, or experimental diet containing 2.5%, 5.0% or 10.0% strawberries displayed tumor incidence of 100%, 64%, 75% and 44%, respectively (p < 0.05). The mechanistic studies demonstrate that strawberries reduced expression of proinflammatory mediators, suppressed nitrosative stress and decreased phosphorylation of phosphatidylinositol 3-kinase, Akt, extracellular signal-regulated kinase and nuclear factor kappa B. In conclusion, strawberries target proinflammatory mediators and oncogenic signaling for the preventive efficacies against colon carcinogenesis in mice. This works supports future development of fully characterized and precisely controlled functional foods for testing in human clinical trials for this disease.     

The rare IRF2BP2-RARA fusion in acute promyelocytic leukemia

Annals of Hematology -     

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population

OBJECTIVE: To investigate whether genetic variation at the UCP3 locus contributes to human obesity. SUBJECTS: Ninety-one obese children (BMI>4 standard deviations from age related mean) and 419 Caucasian adults from the Isle of Ely Study. DESIGN: Single strand conformation polymorphism (SSCP) analysis was used to scan the coding region of the UCP3 gene in 91 severely obese children. A common polymorphism identified in this gene (c-55t) has been shown to associate with lower UCP3 mRNA expression. Polymerase chain reaction-based forced restriction digestion was used to detect this allele in Caucasian adults. Multiple regression analysis was used to determine associations between the c-55t genotype and anthropometric, energetic and biochemical indices relevant to obesity. MEASUREMENTS: For the obese children, SSCP analysis and sequencing of variants were carried out. For the Isle of Ely Study, c-55t genotype and anthropometric (body mass index, waist-hip ratio, percentage body fat), energetic (dietary fat intake, physical activity index, adjusted metabolic rate, maximum oxygen consumption) and biochemical indices (pre- and post-glucose challenge plasma triglycerides, non-esterified fatty acids, insulin and glucose) were determined. RESULTS: A previously reported missense mutation (V102I) was detected in a single obese Afro-Carribean child. Twenty-one percent of the genes examined in the Isle of Ely study carried the c-55t promoter variant. Age-adjusted body mass index (BMI) was significantly (P=0.0037) lower in carriers of this variant. CONCLUSION: Mutations in the coding sequence of UCP3 are unlikely to be a common monogenic cause of severe human obesity. In a Caucasian population the UCP3 c-55t polymorphism is negatively associated with BMI.     

阿托伐他汀在缺血性卒中患者中的疗效研究

目的探讨阿托伐他汀对缺血性卒中患者的疗效。方法收集2012年6月~2014年2月来我院诊治的缺血性卒中患者311例为研究对象,依据其来诊的顺序随机分为实验组与对照组。两组均给予常规内科治疗,实验组加用阿托伐他汀治疗,治疗3个月后,观察两组的治疗效果。结果实验组的临床疗效明显高于对照组;治疗后实验组的总胆固醇、甘油三酯及低密度脂蛋白明显低于对照组,而高密度脂蛋白明显高于对照组。结论阿托伐他汀可以改善缺血性卒中患者血脂水平,提高缺血性卒中患者的治疗效果。