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采用抽空房水C3F8(全氟丙烷)充填前房全眼球湿房保存角膜内皮细胞活性。通过内皮细胞显微照相、内皮细胞活性染色(锥蓝联合茜素红染色)、扫描电镜、保存后的兔角膜行实验性同种异体穿透角膜移植,证实保存7天内皮细胞结构完整,功能良好。 相似文献
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所谓和谐监管,就是进一步树立“以人为本”.“执政为民”的思想,做到依法监管、民主监管和科学监管,努力使监管能力和监管水平与首都经济社会发展水平相适应、与首都医药产业发展环境相协调、与人民群众不断增长的健康消费需求相匹配。 相似文献
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Koji Tomobe Hajime Fujii Buxiang Sun Hiroshi Nishioka Okezie I Aruoma 《Biomedicine & Pharmacotherapy》2007,61(7):427-434
Oligonol is produced from the oligomerization of polyphenols (typically proanthocyanidin from a variety of fruits such as lychees, grapes, apples, persimmons, etc.) and contains catechin-type monomers and oligomers of proanthocyanidins. The ability of Oligonol to affect infection-dependent eye inflammation, locomotion and longevity in senescence-accelerated prone mice (SAMP8) (a model of senescence acceleration and geriatric disorders with increased oxidative stress and neuronal deficit) was investigated. Oligonol (60mg/kg) significantly modulated the extent of inflammation scores in the eye of SAMP8 mice. Examination of the mice indicated infection with mouse hepatitis virus and pinworm (Syphacia obvelata) in both males and females and with the intestinal protozoa (trichomonad) in males. A comparison of the two groups (using log-rank test) and the difference in the mean life span between groups (using Student's t-test) indicated significant differences in survival (p=0.043) and the mean life span (p=0.033) in male SAMP8 mice. Oligonol increased the mean life span and this was statistically significant. In the open-field locomotive test, the 7-week-old SAMP8 mice crossed more than 40 partitioned lines in 1min. At 48-week-old control untreated male SAMP8 crossed 2 lines. The Oligonol-treated 48-week-old male SAMP8 mice crossed 17 lines however. The improved locomotive activity was statistically significant even after 36weeks in the Oligonol-treated male SAMP8 but this was not the case throughout the time course of the study in the Oligonol-treated female SAMP8. Thus Oligonol treatment to SAMP8 mice modulated the severity of infection-dependent inflammation, prolonged life-span and significantly improved locomotive activity indicating potential benefit to aging-associated diseases such as Alzheimer's or Parkinson's diseases. This presents potential for further research to define infection-dependent inflammation associated with degenerative conditions and the molecular mechanism of dietary antioxidant protection. 相似文献
128.
目的 :观察ZMW型环氧乙烷灭菌箱对异体骨材料灭菌效果 ,旨在寻找一种安全、经济的灭菌方法。方法 :清洁条件下取骨 ,制成 0 .5cm× 0 .5cm× 2cm湿润骨材料和干燥骨材料 ,抽取样本 ,用ZMW型环氧乙烷灭菌箱 (15 0L)在不同温度及时间下消毒 ,以环氧乙烷指示胶带是否变色作为灭菌指标 ,样本在消毒前后分别作细菌培养。结果 :不同消毒条件下 ,每批样本均有细菌生长 ,干燥骨材料有菌率高于湿润的骨材料。结论 :ZMW型环氧乙烷灭菌箱不能使异体骨移植材料完全达到灭菌的要求 ,环氧乙烷指示胶带不能作为骨移植材料的灭菌指标 ,干燥可能使细菌的抗环氧乙烷能力增加 ,从而间接的影响了环氧乙烷的消毒效果。 相似文献
129.
探查乳腺肿瘤组织中Ⅰ型纤溶酶原激活物抑制剂(PAI-1)的表达,并比较乳腺恶性肿瘤组织与良性纤继腺瘤及正常组织中PAI-1的差异。用免疫组织化学和原位杂交的方法,确定了乳腺癌、乳腺纤维腺瘤及瘤旁正常组织中PAI-1的分布;用发色底物法检测组织提取液中PAI-1的活性;用图象分析的方法对组织切片上的PAI-1进行灰度定量。结果:PAI-1主要分布在乳腺正常腺上皮细胞、瘤上皮细胞和腺癌细胞的胞浆中,但恶性组织中的成纤维细胞、巨噬细胞以及癌旁纤维组织也有染色。癌组织中PAI-1的活性(P<0.001)和含量(P<0.005)均高于良性乳腺纤维腺瘤及瘤旁正常组织。结论:PAI-1在乳腺恶性肿瘤组织中明显升高,PAI-1的检测可能为临床乳腺肿瘤的诊断、预后提供新的指标。 相似文献
130.
H. W. Chu S. Balzar J. Y. Westcott J. B. Trudeau Y. Sun D. J. Conrad S. E. Wenzel 《Clinical and experimental allergy》2002,32(11):1558-1565
BACKGROUND: Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma. OBJECTIVES: This study was performed to evaluate 15(S)-HETE levels in bronchoalveolar lavage fluid (BALF) from severe asthmatics with and without airway eosinophils and from the control groups. In addition, 15-LO protein expression was examined in endobronchial biopsy, while its expression and activation were evaluated in BAL cells. RESULTS: While 15(S)-HETE levels in BALF were significantly higher in all severe asthmatics than normal subjects, severe asthmatics with airway eosinophils had the highest levels compared with mild, moderate asthmatics and normal subjects. 15(S)-HETE levels were associated with tissue eosinophil numbers, sub-basement membrane thickness and BALF tissue inhibitor of metalloproteinase-1 levels, and were accompanied by increased 15-LO expression in bronchial epithelium. In addition, activation of 15-LO was suggested by the increased proportion of 15-LO in the cytoplasmic membrane of alveolar macrophages from severe asthmatics. CONCLUSION: The data suggest that severe asthmatics with persistent airway eosinophils manifest high levels of 15(S)-HETE in BALF, which may be associated with airway fibrosis. It is likely that 15-LO expression and activation by airway cells explain the increased 15(S)-HETE levels. 相似文献