Clinicopathological and Immunohistochemical Study of Low-Grade Myofibroblastic Sarcoma of the Liver-One Case Report

Low-grade myofibroblastic sarcoma is a recently characterized tumor showing features of myofibroblastic differentiation that is part of the spectrum of malignant mesenchymal tumors.This extremely rare ...     

公立医院建设远程医疗模式探讨析

目前北京大学第三医院已经实现了与延庆县医院、陕西省延安子长县医院的远程医疗系统建设。阐述了远程医疗系统实现及应用效果，提出了建设远程医疗系统过程中出现的问题：同时结合公立医院改革所涉及的远程医疗系统建设给出了意见及看法。     

Analysis on the related factors about the well-being feeling of medical workers.

目的 通过对医务人员幸福感相关因素的分析,提高医务人员工作满意度和工作效率,为增加医疗服务质量和队伍稳定性提供参考.方法 选取汉川市9所乡镇卫生院和市内3所二甲卫生院,应用问卷调查法对332名医务人员进行工作幸福感调查.结果 卫生院医务人员总体幸福感较高；负性情感、健康关注、利他行为、自我价值、友好关系各维度得分处于高水平,生活满意、正性情感、生命活力、人格成长处于中等水平.结论 为提高医务人员幸福感,建议从医务人员的薪酬制度、人文关怀和自身素质培养等方面进行改善.     

初中生网络使用不当与父母养育方式关系初探

目的:探讨初中生网络使用不当与父母养育方式之间的关系,为解决网络使用不当问题提供理论依据。方法:使用父母养育方式评价量表对48名符合Young网络成瘾诊断标准的初中生网络使用不当者和50名健康初中生对照进行测试。结果:1.父母养育方式评价量表中,初中生网络使用不当组父亲因子Ⅰ(情感温暖理解因子)低于对照,而父亲因子Ⅱ(惩罚严厉)、因子Ⅵ(过度保护)两因子得分均高于对照;母亲因子Ⅰ(情感温暖理解因子)同样低于对照,而母亲因子Ⅱ(过干涉过保护)、因子Ⅲ(拒绝否认)以及因子Ⅴ(偏爱被试)各因子得分高于对照。2.父母亲养育方式中母亲的过干涉过保护因子对网络使用不当倾向的预测力居首位(β=0.360),其次是父母亲的情感温暖理解因子和拒绝否认因子(β=-0.308、-0.289,0.267)。结论:初中生网络使用不当者存在不良的家庭教养方式,不利于其人格发展。     

外置式MBR和NF系统运行参数及膜污染控制技术改进

针对北京阿苏卫垃圾卫生填埋场渗沥液处理设备,即MBR和NF设备运行过程中的一些控制参数和传统的膜污染控制技术进行现场记录和分析,并对相关运行参数进行研究和控制,经扩容改造后阿苏卫垃圾卫生填埋场渗沥液工程采用膜污染控制技术,从而使设备稳定运行,最大程度地增加回收率,提高了系统的处理效率。     

局灶节段性肾小球硬化患者常见并发症的分析

目的:观察局灶节段性肾小球硬化(FSGS)患者急性肾损伤(AKI)、感染及血栓栓塞的发生率,探讨并发症发生的危险因素。方法:观察70例经临床及肾脏病理确诊的特发性FSGS患者的AKI、感染及血栓栓塞的发生率,分析并发症的临床特征及高危因素。结果:(1)70例特发性FSGS中,34例(48.6%)并发AKI、14例(20.0%)合并感染、11例(15.7%)出现血栓栓塞。(2)AKI以男性多见,其尿蛋白水平较高,血白蛋白水平较低,小管间质损伤更重,小管急性损伤的程度与AKI的分期有关;随访过程中AKI患者完全缓解率及有效率显著低于未合并AKI者。(3)感染以呼吸道感染多见,院内感染占50%;与非感染组相比,感染组患者的尿蛋白水平更高,血白蛋白、球蛋白、IgG水平则较低;随住院时间延长,感染发生率升高,院内感染所占比例增加;Logistic回归分析显示白蛋白低于20g/L和住院时间延长是感染的独立危险因素。(4)血栓栓塞包括颅内静脉窦血栓2例、颈内静脉血栓1例、右肾静脉血栓1例、股静脉血栓2例、腘静脉血栓2例和肺栓塞3例;血栓栓塞患者的循环内皮细胞计数(CECs)、血管性血友病因子(vWF)高于未合并血栓栓塞者,Logistic回归分析显示CECs和血红蛋白水平升高与血栓栓塞独立相关。结论:FSGS患者肾小管损伤、低白蛋白血症和住院时间延长、血管内皮细胞损伤和血液浓缩分别在AKI、感染、血栓栓塞的发生中起重要作用。     

Rhein lysinate inhibits cell growth by modulating various mitogen-activated protein kinases in cervical cancer cells

In previous studies, we found that rhein lysinate (RHL; the salt of rhein and lysine, easily dissolved in water) inhibited the growth of tumor cells in breast and ovarian cancer and hepatocellular carcinoma. This study aimed to investigate the effect of RHL on the growth of human cervical carcinoma HeLa cells and any underlying mechanisms. RHL inhibited the growth of HeLa cells in a dose- and time-dependent manner. It was also noted that RHL induced apoptosis in HeLa cells in a dose-dependent manner. Mechanistically, RHL triggered HeLa cell apoptosis by increasing the levels of cleaved poly ADP-ribose polymerase (PARP) and caspase-3/7. In addition, the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) was a critical mediator in RHL-induced growth inhibition. Inhibition of the expression of p38 MAPK and JNK by pharmacological inhibitors reversed RHL-induced growth inhibition by decreasing the level of cleaved PARP and caspase-3/7. Phosphorylation of the extracellular signal-related kinase (ERK) was increased by RHL; conversely, the MEK inhibitor which inhibits ERK activity, synergistically enhanced RHL-induced growth inhibition in HeLa cells. The results showed that RHL inhibits Hela cell growth through the activation of p38 MAPK and JNK, and is a potential chemotherapeutic agent for cervical cancer.     

丙泊酚复合不同阿片类药物在老年人结肠镜检查中的镇静效果

目的 探讨丙泊酚复合不同阿片类药物应用于老年人结肠镜检查镇静的效果.方法 60例老年结肠镜受检者随机分为3组,均采用靶控输注方法给予丙泊酚,其中20例单次推注芬太尼(芬太尼组),靶控输注舒芬太尼(舒芬太尼组)、瑞芬太尼(瑞芬太尼组)各20例.记录患者血流动力学改变、镇静深度和不良事件.结果 3组受检患者一般情况、血流动力学改变、镇静深度和不良事件比较差异无统计学意义(均P＞0.05).检查后恢复时间芬太尼组[(21.3±4.6)min]长于舒芬太尼组[(19.9±3.3)min]和瑞芬太尼组[(15.9±1.8)min],且与瑞芬太尼组比较差异有统计学意义(均P＜0.05).结论 丙泊酚复合3种阿片类药物均可安全有效地用于老年人结肠镜检查,但使用瑞芬太尼受检者恢复更为迅速.

Abstract：

Objective To explore the feasibility and safety of fentanyl, sufentanil or remifentanil combined with target-controlled infusion (TCI) of propofol for sedation in the elderly undergoing colonoscopy. Methods In this prospective randomized study, 60 patients undergoing colonoscopy and propofol TCI were randomly assigned to group F (fentanyl), group S (sufentanil) and group R (remifentanil)(each n=20). Patients in group F received a single bolus of fentanyl, while those in group S and group R received TCI sufentanil and remifentanil separately. The blood pressure, heart rate, blood oxygen content and Bispectral index (BIS) were monitored, and all the complications were recorded. Results All patients were adequately sedated. There were no significant differences in general conditions, hemodynamics changes, sedation depth and adverse event among the three groups (all P＞0.05). Time for recovery was longer in group F [(21.3±4.6) min] than in group S [(19.9±3.3) min] and group R [(15.9±1.8) min, P＜0.05]. Conclusions For the elderly undergoing colonoscopy, sedation with fentanyl, sufentanil or remifentanil combined with propofol TCI is feasible and safe. It is more excellent for the remifentanil group at shorter discharge time.