全文获取类型
收费全文 | 90916篇 |
免费 | 8912篇 |
国内免费 | 7361篇 |
专业分类
耳鼻咽喉 | 653篇 |
儿科学 | 846篇 |
妇产科学 | 993篇 |
基础医学 | 10793篇 |
口腔科学 | 1613篇 |
临床医学 | 13107篇 |
内科学 | 13321篇 |
皮肤病学 | 742篇 |
神经病学 | 5310篇 |
特种医学 | 3203篇 |
外国民族医学 | 56篇 |
外科学 | 8398篇 |
综合类 | 15761篇 |
现状与发展 | 22篇 |
一般理论 | 13篇 |
预防医学 | 5988篇 |
眼科学 | 2953篇 |
药学 | 9377篇 |
103篇 | |
中国医学 | 5956篇 |
肿瘤学 | 7981篇 |
出版年
2024年 | 314篇 |
2023年 | 1527篇 |
2022年 | 4307篇 |
2021年 | 5209篇 |
2020年 | 3965篇 |
2019年 | 3221篇 |
2018年 | 3447篇 |
2017年 | 2908篇 |
2016年 | 2845篇 |
2015年 | 4329篇 |
2014年 | 5346篇 |
2013年 | 4554篇 |
2012年 | 6714篇 |
2011年 | 7797篇 |
2010年 | 4737篇 |
2009年 | 3694篇 |
2008年 | 4713篇 |
2007年 | 4596篇 |
2006年 | 4748篇 |
2005年 | 4731篇 |
2004年 | 2766篇 |
2003年 | 2698篇 |
2002年 | 2235篇 |
2001年 | 1961篇 |
2000年 | 2065篇 |
1999年 | 2161篇 |
1998年 | 1442篇 |
1997年 | 1366篇 |
1996年 | 1100篇 |
1995年 | 1017篇 |
1994年 | 844篇 |
1993年 | 534篇 |
1992年 | 601篇 |
1991年 | 509篇 |
1990年 | 465篇 |
1989年 | 420篇 |
1988年 | 347篇 |
1987年 | 296篇 |
1986年 | 228篇 |
1985年 | 178篇 |
1984年 | 81篇 |
1983年 | 50篇 |
1982年 | 41篇 |
1981年 | 36篇 |
1980年 | 24篇 |
1979年 | 21篇 |
1964年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Qun Dong Sandra Kirley Bo Rueda Cher Zhao Lawrence Zukerberg Esther Oliva 《Modern pathology》2003,16(9):863-868
Cables, a cyclin-dependent kinase (cdk) interacting protein, has recently been identified and mapped to human chromosome 18q11. Cables appears to be primarily involved in cell cycle regulation and cell proliferation. Overexpression of Cables in Hela and other cell lines inhibits cell proliferation and tumor formation. We hypothesize that loss of Cables expression is associated with ovarian cancer. To test our hypothesis, we examined Cables expression in the four most common subtypes of ovarian carcinomas: serous, endometrioid, mucinous, and clear cell. In addition, mucinous and serous borderline tumors were also included. Loss of Cables expression was observed at high frequency in ovarian serous (11 of 14 cases, 79%) and endometrioid (5 of 10 cases, 50%) carcinomas. In contrast, strong Cables staining was detected in all clear cell carcinomas (10 cases) and mucinous tumors (5 carcinomas and 5 borderline tumors). The majority of serous borderline tumors (11 of 14 cases, 79%) showed positive Cables staining, with the rest showing focal loss of Cables expression. Furthermore, RT-PCR revealed the lack of Cables mRNA in a human ovarian cancer xenograft. No correlation was noted between loss of Cables and histologic grade, tumor stage, and survival. In conclusion, our results indicate that loss of Cables is common in ovarian serous and endometrioid carcinomas and imply that Cables may be involved in the pathogenesis of these two types of ovarian carcinomas. 相似文献
103.
抗人生长激素免疫血清的制备和鉴定 总被引:1,自引:1,他引:0
Using small dosage of human growth hormone to immunize rabbit or guinea pig, it is able to induce anti-hGH antibody formation with high titre and high affinity that could be applied to hGH RIA. In the present study five rabbits and three guinea pigs were immunized with 125-200 micrograms and 250-285 micrograms per animal of hGH respectively, followed by boosters of 10-20 or 160-250 micrograms of hGH at 2-4 week intervals for 6 or 3 months. Blood was drown 1-2 weeks before each booster for determination of antibody formation. Antibody titre and affinity were successively observed and specificity of antibody was determined for the final bleeding. It was shown that titres of immune sera from guinea pigs were much higher than those of rabbit immune sera, but vice versa for antibody affinity. This might be due to larger immunogen dose used for guinea pigs than for rabbits. Fourteen different peptide hormones were tested in reference to cross-immunoreactivity to anti-hGH antibody. It could be demonstrated that the major cross-reactive hormones are hFSH and hLH, and hTSH also reacts to rabbit anti-hGH immune sera at a lesser degree. These cross reactivities are obviously owing to the molecular homogeneities between hGH and these hormones especially of their alpha-subunits. 相似文献
104.
目的评价高透氧性硬性角膜接触镜(RGPCL)矫正控制中低度近视屈光不正的效果。方法采用RGPCL矫正120眼中低度近视性屈光不正,统计矫正后当天、1年时近视屈光度、散光度的变化。结果观察组的近视度和散光度随戴镜时间延长相对稳定。结论RGPCL对中低近视的度数控制有效。 相似文献
105.
A case of β-thalassemia major with a huge mass of hernatopoictic tissuc firmly attached tothe dura mater was reported This is the first case reported in China. 相似文献
106.
自1980到1986年,我院泌尿外科对4例单纯右侧肾动脉狭窄(RAS)性和3例双侧RAS性高血压病人进行了治疗。7例右侧 RAS皆进行了自体肾移植治疗,其中3例双侧RAS者采用PTA治疗,全部病人术后8天内血压皆恢复正常,随诊10个月到6年,无复发且都恢复工作。1例17岁女孩,术后2年结婚,又2年生一女孩,母女健在血压维持正常。 相似文献
107.
[目的]探讨不同起搏模式对病人生存质量(QOL)的影响。[方法]以健康调查问卷(SF一36量表)对112例不同起搏模式病人进行问卷调查,比较3种起搏模式下病人的QOL水平。[结果]除机体疼痛、角色情绪2个维度外其余6个维度(生理功能、角色限制、活力、社会功能、精神健康、总体健康)3种起搏模式间比较差异有统计学意义(P〈0.05)。[结论]应用AAI型、DDD型起搏器的病人生存质量优于VVI型起搏。 相似文献
108.
109.
Zhou Zhong-yuan周中源 Zhao Wei-bin赵蔚斌 Fu Xin-xiang傅信祥Shanghai Fourth People''s Hospital Shanghai 《中华医学杂志(英文版)》1987,100(2):118-121
Plasma testosterone and estradiol are determined
in 72 patients with abnormal high density lipoprotein.
cholesterol (HDL-C) and high density lipoprotein
cholesterol/total cholesterol (H/T) ratio values, and
in 72 randomly chosen males with normal HDLC
and H/T values. The results showed that plasma
testosterone levels in the groups with abnormal
HDL-C and H/T were obviously lower than those
in the controls. Statistically significant differences
were found in all the abnormal groups in comparison
with the controls (P0.20).
Testosterone levels lowered further with increasing
age in the groups with abnormal HDL-C and H/T.,
the most obvious drops were in the groups around
56 years of age (P<0.005). The data indicate that
male hormone deficiency may reduce HDL-C and
H.'T and facilitate the process of atherosclero_is.
Therefore, it seems rational to treat such patients
with male sex hormone preparations or to use the
traditional Chinese medicines which strengthen Yang
(maleness) in a new attempt to treat and prevent
CHD. 相似文献
110.