全文获取类型
收费全文 | 367篇 |
免费 | 29篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 19篇 |
妇产科学 | 8篇 |
基础医学 | 40篇 |
口腔科学 | 20篇 |
临床医学 | 26篇 |
内科学 | 84篇 |
皮肤病学 | 18篇 |
神经病学 | 23篇 |
特种医学 | 11篇 |
外科学 | 47篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 35篇 |
眼科学 | 3篇 |
药学 | 18篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 23篇 |
2020年 | 9篇 |
2019年 | 18篇 |
2018年 | 23篇 |
2017年 | 14篇 |
2016年 | 10篇 |
2015年 | 15篇 |
2014年 | 7篇 |
2013年 | 16篇 |
2012年 | 31篇 |
2011年 | 35篇 |
2010年 | 8篇 |
2009年 | 24篇 |
2008年 | 28篇 |
2007年 | 36篇 |
2006年 | 27篇 |
2005年 | 24篇 |
2004年 | 10篇 |
2003年 | 14篇 |
2002年 | 7篇 |
2001年 | 3篇 |
1999年 | 2篇 |
1995年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有398条查询结果,搜索用时 31 毫秒
91.
BACKGROUND: Multiple treatment modalities have been employed for the management of melasma with minimal to no success. OBJECTIVE: We propose fractional resurfacing as a new treatment modality for melasma. METHODS: A 31-year-old Caucasian female with facial epidermal and dermal melasma, resistant to multiple courses of topical therapies, was treated with two sessions of full-face fractional resurfacing (Fraxel(TM) Laser; Reliant technologies, San Diego, CA), separated by a three-week interval. Clinical improvement was assessed by Wood's Lamp examination as well as parallel and cross-polarized comparative photography at baseline and 6 months later. RESULTS: Marked reduction in epidermal and dermal facial pigmentation was observed at the six-month follow-up visit. CONCLUSION: Fractional resurfacing may prove to be an effective and safe treatment modality for lightening of the epidermal and dermal pigmentation of melasma. Further studies with long-term follow-up periods and multiple patients with diverse skin phototypes and different variants of melasma are warranted. 相似文献
92.
Pleuropulmonary amebiasis is the 2nd most common extraintestinal site of amebiasis after liver abscess. We describe a man with pleuropulmonary amebiasis presenting with pulmonary consolidation and pleural effusion. In patients with pneumonia coming from endemic countries such as Lebanon, pleuropulmonary amebiasis should be considered in the setting of chocolate-colored sputum, negative respiratory cultures, and failure of antibacterial therapy. 相似文献
93.
Zeina AR Shefer A Sharif D Rosenschein U Barmeir E 《The British journal of radiology》2008,81(965):e141-e144
Myocardial bridging (MB) is defined as an intramural segment of a coronary artery that normally courses epicardially. MB is usually a benign condition; however, some cases resulting in myocardial ischaemia, infarction and sudden death have been reported. We describe a case of myocardial infarction related to MB in a young healthy woman with no risk factors for coronary artery disease. The bridge was demonstrated in detail by coronary CT angiography using multiplanar reconstruction and three-dimensional volume-rendered techniques. 相似文献
94.
Emma Quinn Kai Hsun Hsiao Isis Maitland-Scott Maria Gomez Melissa T Baysari Zeina Najjar Leena Gupta 《JMIR Public Health and Surveillance》2021,7(4)
BackgroundWeb-based technology has dramatically improved our ability to detect communicable disease outbreaks, with the potential to reduce morbidity and mortality because of swift public health action. Apps accessible through the internet and on mobile devices create an opportunity to enhance our traditional indicator-based surveillance systems, which have high specificity but issues with timeliness.ObjectiveThe aim of this study is to describe the literature on web-based apps for indicator-based surveillance and response to acute communicable disease outbreaks in the community with regard to their design, implementation, and evaluation.MethodsWe conducted a systematic search of the published literature across four databases (MEDLINE via OVID, Web of Science Core Collection, ProQuest Science, and Google Scholar) for peer-reviewed journal papers from January 1998 to October 2019 using a keyword search. Papers with the full text available were extracted for review, and exclusion criteria were applied to identify eligible papers.ResultsOf the 6649 retrieved papers, 23 remained, describing 15 web-based apps. Apps were primarily designed to improve the early detection of disease outbreaks, targeted government settings, and comprised either complex algorithmic or statistical outbreak detection mechanisms or both. We identified a need for these apps to have more features to support secure information exchange and outbreak response actions, with a focus on outbreak verification processes and staff and resources to support app operations. Evaluation studies (6 out of 15 apps) were mostly cross-sectional, with some evidence of reduction in time to notification of outbreak; however, studies lacked user-based needs assessments and evaluation of implementation.ConclusionsPublic health officials designing new or improving existing disease outbreak web-based apps should ensure that outbreak detection is automatic and signals are verified by users, the app is easy to use, and staff and resources are available to support the operations of the app and conduct rigorous and holistic evaluations. 相似文献
95.
Displaced children with cancer in Lebanon: A sustained response to an unprecedented crisis
下载免费PDF全文
![点击此处可从《Cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
96.
Janani S. Reisenauer Wadad Mneimneh Sarah Jenkins Aaron S. Mansfield Marie Christine Aubry Karen J. Fritchie Mark S. Allen Shanda H. Blackmon Stephen D. Cassivi Francis C. Nichols Dennis A. Wigle K. Robert Shen Jennifer M. Boland 《Journal of thoracic oncology》2018,13(9):1349-1362
Introduction
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms. Most follow a benign course, but a subset will recur or metastasize. Various risk stratification schemes have been proposed for SFTs, but none has been universally endorsed and few have focused on pleuropulmonary SFTs.Methods
Histologic sections from surgically resected pleuropulmonary SFTs were examined, with confirmatory immunohistochemistry. Patients were risk-stratified by using four prediction models as proposed by de Perrot, Demicco (original and modified), and Tapias. Kaplan-Meier analysis was used to estimate overall survival (OS) and progression-free survival (PFS).Results
The 147 study patients included 78 females (53.1%) with a median age of 61.5 years (range 25–87). The median follow-up was 5.5 years (range 0–33). Recurrence or metastasis occurred in 15 patients (10.2%), with five deaths from disease. Significant predictors of worse OS included male sex, age at least 55 years, tumor size at least 10 cm, nonpedunculated growth, severe atypia, necrosis, and mitotic count of at least four per 10 high-power fields. Predictors of recurrence included tumor size of at least 10 cm, severe atypia, necrosis, at least four mitoses per 10 high-power fields, and Ki67 labeling index of at least 2%. All systems predicted PFS, but only the Demicco and Tapias systems significantly predicted OS. The modified Demicco system provided the best discrimination for PFS (C-statistic = 0.80 compared with 0.78).Conclusion
The risk scoring systems proposed by Tapias et al. and Demicco et al. were both predictive of OS and PFS. The Demicco system has the advantages of simplicity and applicability to SFTs from other sites, as well as provision of the best discrimination for PFS, and thus may be the best system to apply in general practice. 相似文献97.
98.
99.
Background
Palestinian refugees living in Lebanon continue to face social and economic exclusion that hinders their ability to improve their living conditions and livelihoods. This study aimed to investigate the effect of a two-pronged intervention that employed women through social enterprises to deliver a subsidised healthy daily school meal to elementary schoolchildren in Palestinian camps.Methods
We established two healthy kitchens in community-based organisations in Palestinian camps; these kitchens employed 32 women to provide daily meals to children attending primary schools. We used mixed methods to assess the effect of participating in the intervention on the women's economic, social, and food security outcomes. We also assessed the impact of the subsidised meal programme on children's dietary diversity, nutritional status, school absenteeism, and achievement in two intervention schools, compared to two control schools. Difference-in-difference and regression analyses were conducted to examine the associations between participation and outcomes, controlling for potential confounders. Quantitative and qualitative data analyses were conducted using Stata 13·0 and NVivo 10, respectively. Written informed consent was obtained from women and parents, followed by assent from children prior to participation. All study protocols were approved by the Institutional Review Boards of the American University of Beirut and the University of Maryland.Findings
At baseline, women's median household expenditure was US$169 per capita per month. Additional income due to the intervention was equivalent to US$110 per month, which translated into increases in total household and food expenditures (p=0·040), as well as a reduction in food insecurity (p=0·006). Qualitative data found improvements in morale, social support, and decision making. There were 648 children in the control group, and in the meal programme group there were 260 children with low participation (LP; participated less than 50% of total school days) and 454 with high participation (HP; participated more than 50% of total school days). There was a significantly greater increase in overall diet diversity score (Δ0·32, p=0·0060) and dairy consumption (odds ratio 1·2, 95% CI 1·1–1·3) in the HP group compared to controls. Both LP and HP groups were more likely to consume proteins, and less likely to consume sweetened beverages and desserts than controls. Furthermore, the HP group had a significant increase in haemoglobin (p=0·05) and both LP and HP groups had a significant decrease in school absenteeism (p=0·04) compared with controls.Interpretation
This study provides evidence of the positive effect of the Healthy Kitchens, Healthy Children model on economic, food security, and social outcomes of marginalised women, as well as diet diversity, haemoglobin, and school outcomes of children. This intervention contributed to human capital gains in two generations of protracted refugees.Funding
The Nestle Foundation for the Study of Problems of Nutrition in the World. 相似文献100.
Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice
下载免费PDF全文
![点击此处可从《Environmental and molecular mutagenesis》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sonja Christensen Zeina Jaffar Elizabeth Cole Virginia Porter Maria Ferrini Britten Postma Kent E. Pinkerton Mihi Yang Yang Jee Kim Luke Montrose Kevan Roberts Andrij Holian Yoon Hee Cho 《Environmental and molecular mutagenesis》2017,58(6):423-433
Allergic asthma remains an inadequately understood disease. In utero exposure to environmental tobacco smoke (ETS) has been identified as an environmental exposure that can increase an individual's asthma risk. To improve our understanding of asthma onset and development, we examined the effect of in utero ETS exposure on allergic disease susceptibility in an asthmatic phenotype using a house dust mite (HDM) allergen‐induced murine model. Pregnant C57BL/6 mice were exposed to either filtered air or ETS during gestation, and their offspring were further exposed to HDM at 6–7 weeks old to induce allergic inflammation. Methylation in the promoter regions of allergic inflammation‐related genes and genomic DNA was quantified. Exposure to HDM resulted in the onset of allergic lung inflammation, with an increased presence of inflammatory cells, Th2 cytokines (IL‐4, IL‐5, and IL‐13), and airway remodeling. These asthmatic phenotypes were significantly enhanced when the mice had been exposed to in utero ETS. Furthermore, prenatal ETS exposure and subsequent HDM (ETS/HDM)‐induced asthmatic phenotypes agree with methylation changes in the selected asthma‐related genes, including IL‐4, IL‐5, IL‐13, INF‐γ, and FOXP3. Global DNA methylation was significantly lower in ETS/HDM‐exposed mice than that of controls, which coincides with the results observed in lung, spleen, and blood DNAs. Prenatal ETS exposure resulted in a severe increase in allergic inflammatory responses after an HDM challenge, with corresponding methylation changes. Prenatal ETS exposure may influence developmental plasticity and result in altered epigenetic programming, leading to an increased susceptibility to asthma. Environ. Mol. Mutagen. 58:423–433, 2017. © 2017 Wiley Periodicals, Inc. 相似文献