全文获取类型
收费全文 | 1135篇 |
免费 | 90篇 |
国内免费 | 19篇 |
专业分类
儿科学 | 78篇 |
妇产科学 | 4篇 |
基础医学 | 136篇 |
口腔科学 | 65篇 |
临床医学 | 126篇 |
内科学 | 200篇 |
皮肤病学 | 46篇 |
神经病学 | 59篇 |
特种医学 | 252篇 |
外科学 | 82篇 |
综合类 | 29篇 |
预防医学 | 48篇 |
眼科学 | 13篇 |
药学 | 40篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 64篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 5篇 |
2020年 | 9篇 |
2019年 | 9篇 |
2018年 | 15篇 |
2017年 | 7篇 |
2016年 | 12篇 |
2015年 | 28篇 |
2014年 | 24篇 |
2013年 | 44篇 |
2012年 | 23篇 |
2011年 | 23篇 |
2010年 | 54篇 |
2009年 | 55篇 |
2008年 | 28篇 |
2007年 | 37篇 |
2006年 | 30篇 |
2005年 | 33篇 |
2004年 | 19篇 |
2003年 | 31篇 |
2002年 | 22篇 |
2001年 | 21篇 |
2000年 | 5篇 |
1999年 | 23篇 |
1998年 | 82篇 |
1997年 | 76篇 |
1996年 | 59篇 |
1995年 | 53篇 |
1994年 | 37篇 |
1993年 | 45篇 |
1992年 | 9篇 |
1991年 | 24篇 |
1990年 | 20篇 |
1989年 | 45篇 |
1988年 | 39篇 |
1987年 | 30篇 |
1986年 | 21篇 |
1985年 | 25篇 |
1984年 | 12篇 |
1983年 | 13篇 |
1982年 | 16篇 |
1981年 | 14篇 |
1980年 | 15篇 |
1979年 | 3篇 |
1978年 | 13篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1954年 | 1篇 |
排序方式: 共有1244条查询结果,搜索用时 15 毫秒
21.
Mykytenko J Reeves JG Kin H Wang NP Zatta AJ Jiang R Guyton RA Vinten-Johansen J Zhao ZQ 《Basic research in cardiology》2008,103(5):472-484
This study tested the hypothesis that inhibition of myocardial injury and modulation of mitochondrial dysfunction by postconditioning (Postcon) after 24 h of reperfusion is associated with activation of K(ATP) channels. Thirty dogs undergoing 60 min of ischemia and 24 h of reperfusion (R) were randomly divided into four groups: Control: no intervention at R; Postcon: three cycles of 30 s R alternating with 30 s re-occlusion were applied at R; 5-hydroxydecanoate (5-HD): the mitochondrial K(ATP) channel blocker was infused 5 min before Postcon; HMR1098: the sarcolemmal K(ATP) channel blocker was administered 5 min before Postcon. After 24 h of R, infarct size was smaller in Postcon relative to Control (27 +/- 4%* Vs. 39 +/- 2% of area at risk), consistent with a reduction in CK activity (66 +/- 7* Vs. 105 +/- 7 IU/g). The infarct-sparing effect of Postcon was blocked by 5-HD (48 +/- 5%(dagger)), but was not altered by HMR1098 (29 +/- 3%*), consistent with the change in CK activity (102 +/- 8(dagger) in 5-HD and 71 +/- 6* IU/g in HMR1098). In H9c2 cells exposed to 8 h hypoxia and 3 h of reoxygenation, Postcon up-regulated expression of mito-K(ATP) channel Kir6.1 protein, maintained mitochondrial membrane potential and inhibited mitochondrial permeability transition pore (mPTP) opening evidenced by preserved fluorescent TMRE and calcein staining. The protective effects were blocked by 5-HD, but not by HMR1098. These data suggest that in a clinically relevant model of ischemia-reperfusion (1) Postcon reduces infarct size and decreases CK activity after prolonged reperfusion; (2) protection by Postcon is achieved by opening mitochondrial K(ATP) channels and inhibiting mPTP opening. *P < 0.05 Vs. Control; (dagger) P < 0.05 Vs. Postcon. 相似文献
22.
23.
Long‐term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6‐month randomized,vehicle‐controlled clinical trial 下载免费PDF全文
24.
25.
AJ Osborne R Clancy GWB Clark C Wong 《Annals of the Royal College of Surgeons of England》2013,95(2):131-133
Introduction
Single incision laparoscopic surgery (SILS) is established in many procedures but not in bariatric surgery. One explanation may be that SILS is technically demanding in morbidly obese patients. This report describes our technique and experience with single incision laparoscopic adjustable gastric banding (SILAGB).Methods
Prospective data collection was performed on consecutive obese patients who underwent SILAGB between November 2009 and February 2011. A single 3cm transverse incision in the right upper quadrant was used for a Covidien SILS™ multichannel access port. The technique is described with a standard pars flaccida approach and the ‘tips and tricks’ needed for a wide range of candidates using standard laparoscopic equipment.Results
A total of 29 patients (27 female) with a median body mass index of 41kg/m2 (range: 35–52kg/m2) and median age of 44 years (range: 22–57 years) underwent SILAGB. There were no ‘conversions’ to a standard laparoscopic technique. Two cases required the addition of one single 5mm port. The only complications were two postoperative wound infections (one with a port site infection requiring replacement of the port) and one faulty band requiring replacement. There were therefore two returns to theatre and no 30-day deaths. All patients were discharged on the first postoperative day. In this series, operative times reduced significantly to be comparable with the conventional laparoscopic approach.Conclusions
SILAGB is safe and feasible in the morbidly obese. Proficiency in this technique using conventional laparoscopic equipment can be achieved with a short learning curve. 相似文献26.
S Jegatheeswaran T Satyadas AJ Sheen T Treasure AK Siriwardena 《Annals of the Royal College of Surgeons of England》2013,95(2):140-143
Introduction
Distant metastases to liver and lung are not uncommon in colorectal cancer. Resection of metastases is accepted widely as the standard of care. However, there is no firm evidence base for this. This questionnaire survey was carried out to assess the current practice preferences of cardiothoracic surgeons in Great Britain and Ireland.Methods
An online questionnaire survey was emailed to cardiothoracic surgeons in Great Britain and Ireland. The survey was live for 12 weeks. Responses were collated with SurveyMonkey®.Results
Overall, there were 75 respondents. The majority (83%) indicated thoracic surgery as a specialist interest. Almost all (99%) used thoracic computed tomography (CT) for staging; 70% added liver CT and 51% added pelvic CT. Fluorodeoxyglucose positron emission tomography was used by 86%. The most frequent indication for pulmonary resection (97%) was solitary lung metastasis without extrathoracic disease. Video assisted thoracoscopic surgery (VATS) was used by 85%. In addition, thoracotomy was used by 96%. A third (33%) used radiofrequency ablation. Synchronous liver and lung resection was contraindicated for 83% of respondents. Over three-quarters (77%) thought that scientific equipoise exists presently for lung resection for colorectal lung metastases but only 21% supported a moratorium on this type of surgery until further evidence becomes available.Conclusions
The results confirm that the majority of respondents use conventional cross-sectional imaging and either VATS or formal thoracotomy for resection. The results emphasise the continuing need for formal randomised trials to provide evidence of any survival benefit from pulmonary metastasectomy for colorectal lung metastases. 相似文献27.
28.
29.
30.