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991.
Buckley Elizabeth Elder Elisabeth McGill Sarah Kargar Zahra Shahabi Li Ming Roder David Currow David 《Breast cancer research and treatment》2021,187(2):547-555
Breast Cancer Research and Treatment - Different tumor-related factors have been proposed to assess the risk of disease progression and death in women undergoing neoadjuvant breast cancer... 相似文献
992.
Cardiac,Hepatic and Renal Dysfunction and IL-18 Polymorphism in Breast,Colorectal, and Prostate Cancer Patients
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Govand Qader Mukhlis Aali Shukur W Smail Kazhan Mahmood Bestoon Hasan Karwan M-Amen Dlzar Bayz Rahman Fikry A Qadir Dara K Mohammad Hastyar H Najmuldeen Fryad Majeed Rahman Seepal Ibrahim Ahmad Nergz S Salih Zainab M Khdhr Bushra A Mohammed Asuda M Majeed Xanda M Hasan Bushra H Khidhir Eman S Muhammad Bahar A Muhamadsalih Simav K Hasan Aram J Hamad Zahra K Esmail Chra M Ismael Shan M Husaen Chiavan A Abdulla Bashdar M Hussen Zjwan Housein Mudhir Shekha Abbas Salihi 《Asian Pacific journal of cancer prevention》2021,22(1):131-137
Introduction: The present study aimed to determine the alterations in the serum levels of tumor markers used to evaluate cardiac, renal and liver function, and detect the interleukin (IL)-18 rs1946518 polymorphism in breast (BC), colorectal (CRC) and prostate cancer (PCa) patients. Methods: Blood samples were collected from 65 female BC, 116 CRC, 79 PCa and 88 myocardial infarction (MI) patients, and 110 healthy individuals to determine the concentration of tumor and cardiac markers. Furthermore, the IL-18 rs1946518 polymorphism was assessed using amplification refractory mutation system (ARMS)-PCR. Results: The serum levels of the tumor markers cancer antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA) and total prostate-specific antigen (TPSA) were significantly increased in cancer patients compared with healthy controls. Furthermore, the activity of high-sensitivity cardiac troponin T (hs-cTnT) and creatine kinase‑myocardial band (CK-MB) was enhanced in MI patients, however, their activity was unchanged in cancer patients. The activity of alkaline phosphatase (ALP), and the serum concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and urea were markedly elevated in CRC and PCa patients, respectively, compared with the control group. Although, no significant differences were observed in the -607 C/A polymorphism and allele frequency of IL-18 among BC, CRC patients and healthy individuals, the odds ratio (OR) was 1.75 for both C and A allele in BC patients. Therefore, the -607 C/A polymorphism could be considered as a risk factor for BC. Conclusion: The aforementioned results suggested that tumor markers could be considered as excellent biomarkers for the early detection of BC, CRC and PCa, whereas the concentration of liver enzymes could serve as an alternative indicator for the diagnosis of CRC and PCa. Additionally, the rs1946518 polymorphism in the IL-18 gene could be considered as a risk factor for the occurrence of BC, CRC and PCa. 相似文献
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Zahra Jalayeri-Darbandi Aliakbar Rajabzadeh Mahmoud Hosseini Farimah Beheshti Alireza Ebrahimzadeh-bideskan 《Anatomical science international / Japanese Association of Anatomists》2018,93(3):351-363
The aim of this study was to evaluate the effect of methamphetamine (MA) exposure during pregnancy and lactation on doublecortin (DCX) expression in the hippocampus of rat offspring and also on learning/memory. Thirty-five pregnant Wistar rats were randomly divided into seven groups of 5 rats each: three experimental groups, each receiving 5 mg/kg body weight (BW) intraperitoneal (i.p.) injections of MA during pregnancy or/and lactation; three sham groups, each receiving saline injections; one control group, receiving no injection. After the interventions, two male pups (1 and 22 days old) were randomly selected from each mother, sacrificed and their brains subjected to DCX immunohistochemistry. One additional male pup from each mother was randomly selected and maintained for 60 days for testing in the Morris water maze and passive avoidance tests. MA administration during pregnancy was found to have significantly decreased the number of DCX-positive cells in the CA1, CA3 and DG regions of the hippocampus in the 1-day pups (P ≤ 0.05) and to have significantly decreased the number of DCX-positive cells in only two regions of the hippocampus, the CA1 and DG regions, in 22-day old pups. In comparison, exposure to MA during lactation was only associated with a significant decrease in the number of DCX-positive cells in the DG. Exposure to MA during pregnancy had significant impact on the intensity of DCX expression in the hippocampus of 1- and 22-day pups (P ≤ 0.05). There was no significant difference in memory/learning among the study groups. Our results indicate the administration of MA during pregnancy had a greater effect that during the lactation period on DCX expression in the hippocampus of rat offspring. 相似文献
999.
Richard Teo Josefina C. Farrá Zahra F. Khan Andrea R. Marcadis John I. Lew 《Surgery》2018,163(2):393-396
Background
The importance of intraoperative parathormone “spikes” during parathyroidectomy remains unclear. This study compared patients with and without intraoperative parathormone spikes during parathyroidectomy using the criterion of a?>?50% parathormone and determined the effect of intraoperative parathormone spikes on operative outcome.Methods
We performed a retrospective review of prospectively collected data on 683 patients who underwent parathyroidectomy guided by intraoperative parathormone monitoring. An intraoperative parathormone “spike value” was calculated by subtracting the preincision intraoperative parathormone value from the pre-excision intraoperative parathormone value (SV?=?PE???PI). An intraoperative parathormone spike was defined as having a positive spike value ≥9?pg/mL (≥10th percentile of all spike values).Results
Of 683 patients, 224 (33%) had intraoperative parathormone spikes and a greater rate of multiglandular disease (8% vs. 3%, P?<?0.05) and bilateral neck exploration (10% vs. 5%, P?<?0.05) compared with patients without intraoperative parathormone spikes. Overall, there were no differences between parathyroidectomy patients with and without intraoperative parathormone spikes in terms of operative success (98.2% vs. 98.0%), failure (1.8% vs. 2.0%), or recurrence rates (0.4% vs. 1.3%).Conclusions
Although the presence of intraoperative parathormone spikes may increase suspicion for multiglandular disease, the ability of intraoperative parathormone monitoring to predict operative success after parathyroidectomy is not affected by spikes. 相似文献1000.
Robabeh Abedini Pardis Sasani Hamid Reza Mahmoudi Maryam Nasimi Amir Teymourpour Zahra Shadlou 《Burns : journal of the International Society for Burn Injuries》2018,44(6):1482-1488