Comparison of applying particulate demineralized bone matrix (DBM), putty DBM and open flap debridement in periodontal horizontal bone defects. A 12-month longitudinal, multi-centre, triple-blind, split-mouth, randomized, controlled clinical study. Part 2 – evaluation of the interdental soft tissue

Summary To date, there have been many studies clinically evaluating periodontal regenerative procedures by the help of routinely used hard and soft tissue parameters; however, these parameters are not capable of assessing interdental soft tissue located above the regenerative periodontal surgery area. The purpose of this study was to assess interproximal soft tissue changes following application of (i) particulate form demineralized bone matrix (DBM), (ii) putty form DBM and (ii) open flap debridement (OFD, control), using modified curtain technique in the treatment of interproximal suprabony (horizontal) defects located in anterior maxillary region, as previously reported. Twenty‐five chronic periodontitis patients with 125 interproximal surgery sites (radiologically ≥4 mm horizontal bone defect) were also participate in this second stage of the triple‐blind, split mouth, randomized, controlled clinical trial. Surgery sites were assessed by (i) plaque index (PI), (ii) gingival index (GI), (iii) the presence of interdental soft tissue clefts or craters and (iv) the loss of interdental papilla height by using papilla presence index (PPI), during the healing period. At the baseline and 3, 6, 9 and 12 months after the operations, these measurements were repeated. In all groups, there is a significant increase in the prevalence of soft tissue cleft and crater formation (P < 0·01), with increase in PI and GI scores at interdental soft tissue defect areas (P < 0·001), 3 months after the operations. There was also an increase in PPI scores after the operations in all treatment groups (P < 0·01). Three procedures affected the interproximal soft tissues similarly. There was no significant difference among groups in terms of all parameters (P > 0·05). Particulate DBM, putty DBM and OFD demostrated similar interproximal soft tissue changes especially increasing interproximal PI and GI scores in 3 months follow‐up.     

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

OBJECTIVE: We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion. METHODS: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose 1 h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. RESULTS: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P<0.05, P<0.001 and P<0.001, respectively). A statistical difference was not found among study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P>0.05). The T-SH level in the study group was significantly higher than in the IR, sham and sham plus trapidil groups in left testis P<0.05). In the IR group (left testis), grade 1 interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade 1 interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). CONCLUSION: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis.     

Spermatic cord metastasis as an initial manifestation of non-small cell carcinoma of the lung

Lung cancer is among the most common cancers which continue to be a major cause of death in the world and many present with distant metastasis in advanced stages precluding curative treatment. Herein, we report a 62-year-old male patient admitted to our hospital with complaint of a painful mass in his left inguinal region. Surprisingly, a chest radiograph revealed a mass in his left lung with ipsilateral pleural effusion. Thorough radiological and pathologic examinations he was confirmed to have a non-small cell lung cancer with only spermatic cord metastasis and unfortunately the patient died two weeks after admission.     

Comparison of trace element concentrations in cancerous and noncancerous human endometrial and ovary tissues

Question of whether trace metal concentrations in tissues are increased or decreased in cancerous patients in comparison with noncancerous patients has not been answered yet, due to the fact that the data known in this field are rare and have contradictory results. Although Zn and Cu concentrations in serum and tissues of cancerous patients have extensively been studied, the precise role of these metals in carcinogenesis is not clearly understood. There are few studies on the concentrations of essential and toxic trace/minor metals in human tissue samples in comparison with serum and plasma samples. Trace metal concentrations including Cd, Cu, Zn, Fe, Mg, Ca, and Ni in both cancerous and noncancerous endometrial, ovary, and cervix uteri tissues were determined by atomic absorption spectrometry. The tissue samples were digested by using microwave energy. Slotted tube atom trap was used to improve the sensitivity of copper and cadmium in flame atomic absorption spectrometry determination. The concentrations of iron in cancerous endometrial tissues were found to be significantly higher than those in noncancerous samples (P < 0.01). On the contrary Fe, Zn concentration in cancerous endometrial tissue was found to be lower significantly than those in noncancerous samples (P= 0.005), whereas the other studied metals were not observed different. Furthermore, Cu and Ca concentrations in cancerous ovary samples were observed to be higher than those in noncancerous ovary tissues (P < 0.01 for Cu and P= 0.1 for Ca), whereas Mg, Fe, and Zn levels in cancerous ovary samples were not found to be different than those in noncancerous tissues.     

48例女性冠心病的临床特点分析

目的:探讨女性冠心病的临床特点。方法:比较48例住院女性冠心病患者与同时期110例男性患者的病例资料,分析其临床特点。结果:(1)女性冠心病的发病年龄较男性晚,两组比较差异有显著性(P<0.05);(2)绝经为女性冠心病的特殊危险因素;(3)女性选择非介入治疗者多于男性,预后较男性差,两组比较差异有显著性(P<0.05)。结论:女性冠心病具有不同于男性的临床特点。     

An alternative supplemental feeding method for preterm infants: the supplemental feeding tube device

Background/aimThe purpose of this study was to determine the effects of the supplemental feeding tube device (SFTD) and bottle methods on weight gain, transition to full breastfeeding, breastfeeding success, and duration of discharge in preterm infants.Materials and methodsThis randomized controlled trial was conducted with a total of 46 preterm infants including 23 infants in study (SFTD) and control (bottle) groups. An information form, an infant follow-up form for feeding, and LATCH breastfeeding assessment instrument were used to collect the data.ResultsThe gestation week of the infants in the study group was 31.22 ± 2.76, and in the control group it was 30.52 ± 2.47. The birth weight of the infants in the study group was 1586.3 ± 525.35 g and 1506.09 ± 454.77 g in the control group. The daily weight gain of the infants was 24.09 ± 15.21 g in the study group and 27.17 ± 17.63 g in the control group. The infants in the study group (4.70 ± 2.44 days) transitioned to full breastfeeding earlier than those in the control group (6.00 ± 4.10 days). LATCH 2nd measurement scores were significantly higher in both groups than LATCH 1st measurement scores (p < 0.01). Although it was not statistically significant (p > 0.05), the infants in the study group (10.22 ± 5.20 days) were discharged earlier than those in the control group (13.48 ± 8.78 days).ConclusionThe SFTD and bottle methods were determined to be similar in terms of daily weight gain, transition to full breastfeeding, breastfeeding success, and duration of hospitalization.     

Foot deformities in patients with rheumatoid arthritis: the relationship with foot functions

Aim: The aim of this study was to investigate foot deformities in patients with rheumatoid arthritis (RA), to detect frequency of deformities and to assess the relationship between foot deformities and foot functions. Methods: Anteroposterior and lateral radiographs of 40 patients and 40 control subjects were studied. The hallux valgus (HV) angle, intermetatarsal angle between first and second metatarsals, intermetatarsal angle between first and fifth metatarsals, and calcaneal pitch were measured on radiographs. Foot functions were measured by the Foot and Ankle Outcome Score (FAOS). Results: The frequency of foot deformities in RA patients was determined as 78.8%. The most frequent foot deformity in RA patients was HV (62.5%), followed by metatarsus primus varus (MPV) (41.3%). MPV and splaying of the forefoot deformities were significantly more frequent in RA patients than the control group (P < 0.05). Mild to moderate effect on FAOS subscales was observed in RA patients. There was a slight, but significant correlation between the foot deformities and the FAOS subscales except for quality of life subscale. Conclusions: In this study, it has been shown that foot deformities are frequent in patients with RA and that there is slight deterioration in foot functions related to RA. Our results indicated that foot deformities have small, but clinically important changes on foot functions. There is a need for more studies, which evaluates the foot deformities, to further explore the relationship between the foot deformities and foot function in patients with RA.