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91.
Shinichiro Okamoto Yoshitaka Miyakawa Jonathan Smith Ian Hodgson Brihad Abhyankar Steven Troy Yuzuru Kanakura 《International journal of hematology》2013,97(3):360-368
Although anagrelide is widely used for the treatment of essential thrombocythemia (ET) in the USA and Europe, it is not licensed in Japan. Existing literature has reported differences in polymorphism and activity of CYP1A2 in Japanese and non-Japanese ethnic groups, which may alter anagrelide metabolism. We intended to identify the optimum dosage of anagrelide in treatment-naïve Japanese patients with ET and assess its long-term safety and efficacy. Twelve patients with ET and a platelet count of ≥80 × 104/μL were enrolled. Anagrelide was administered at an initial dose of 0.5 mg/day (weeks 1–4), then increased to 1.0 mg/day (weeks 5–8). During the following maintenance (weeks 9–52) and continuation periods (weeks 53–104), the dose was adjusted according to patient safety data and to maintain target platelet counts (<60 × 104/μL). Increasing the dose led to a decrease in mean platelet count, and target platelet counts were maintained in 11 patients. Adverse events were mild or moderate, and none led to discontinuation. This cohort of Japanese patients exhibited higher pharmacokinetic exposures of anagrelide and its active metabolite than those previously documented in non-Japanese patients. These differences were modest, suggesting specific dosing regimens for Japanese patients are not required. 相似文献
92.
Rena Kaneko Masazumi Ogawa Tomoyuki Iwata Yasuyoshi An Motoki Nakagawa Satoshi Kusayanagi Satoshi Kamisago Tomoyuki Umeda Yuzuru Sato 《Clinical journal of gastroenterology》2009,2(4):296-299
Pegylated interferon alpha combined with ribavirin is currently the standard treatment for hepatitis C virus (HCV) infection.
Ursodeoxycholic acid (UDCA) is used as a complementary treatment in patients who are non-responders or who develop severe
side effects of this combined therapy. UDCA is generally considered to be a relatively safe drug. However, we recently encountered
a patient with chronic hepatitis C in whom interferon-induced interstitial pneumonia was exacerbated by UDCA. This patient
responded to initial antiviral therapy with non-pegylated interferon alpha-2b and ribavirin, but hepatitis recurred soon after
the end of treatment. A second course of antiviral therapy using peginterferon alpha-2b and ribavirin achieved normalization
of serum transaminases and HCV-RNA, but also caused interstitial pneumonia. After discontinuing peginterferon, this side effect
was ameliorated. On the other hand, hepatitis relapsed four months later. UDCA treatment was started and serum transaminase
levels decreased, but exacerbation of interstitial pneumonia occurred with marked elevation of the serum KL-6 level. To our
knowledge, this is the first reported case of peginterferon-induced interstitial pneumonia showing exacerbation due to UDCA
therapy. 相似文献
93.
Daiki Hirano Shiro Oka Shinji Tanaka Kyoku Sumimoto Yuki Ninomiya Yuzuru Tamaru Kenjiro Shigita Nana Hayashi Yuji Urabe Yasuhiko Kitadai Fumio Shimamoto Koji Arihiro Kazuaki Chayama 《BMC gastroenterology》2017,17(1):158
Background
Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aimed to clarify the clinicopathologic and endoscopic characteristics of early-stage SACs.Methods
Forty consecutive early-stage SAC patients at Hiroshima University Hospital were enrolled; SACs were classified into epithelial serration (Group A, n?= 17) and non-epithelial serration (Group B, n?=?23) groups. Additionally, we classified serrated adenoma into 4 types: sessile serrated adenoma (SSA), traditional serrated adenoma (TSA), unclassified, and non-serrated adenoma type.Results
There were significant differences between Groups A and B in terms of tumor size (27.6 vs. 43.1 mm), incidences of T1 carcinoma (71% vs. 13%), and having the same color as normal mucosa (47% vs. 17%), respectively (p?<0.01). In SACs >20 mm, the incidence of T1 carcinoma in Group A (70%) was significantly greater than that in Group B (13%) (p?<0.05). There were significant differences in ‘Japan NBI Expert Team’ type 3 and type V pit pattern classifications between the 2 groups. The average TSA-type tumor size (42.6 mm) was significantly larger than that of the SSA (17.2 mm) and non-serrated component types (18.3 mm). The incidences of submucosal invasion in SSA- (80%), unclassified- (100%), and non-serrated-type (100%) tumors were significantly higher than that in the TSA type (11%).Conclusions
Epithelial serration in the cancerous area and a non-TSA background indicated aggressive behavior in early-stage SACs.94.
Continuation of antithrombotic therapy may be associated with a high incidence of colonic post‐polypectomy bleeding 下载免费PDF全文
Tomoyoshi Shibuya Osamu Nomura Tomohiro Kodani Takashi Murakami Hirofumi Fukushima Yuzuru Tajima Kohei Matsumoto Hideaki Ritsuno Hiroya Ueyama Yoshihiro Inami Dai Ishikawa Kenshi Matsumoto Naoto Sakamoto Taro Osada Akihito Nagahara Tatsuo Ogihara Sumio Watanabe 《Digestive endoscopy》2017,29(3):314-321
95.
Lymphatic Microvessel Density is an Independent Prognostic Factor in Colorectal Cancer 总被引:5,自引:0,他引:5
Matsumoto K Nakayama Y Inoue Y Minagawa N Katsuki T Shibao K Tsurudome Y Hirata K Nagata N Itoh H 《Diseases of the colon and rectum》2007,50(3):308-314
Purpose Although lymph node metastasis via lymphatic vessels often is related with an adverse outcome, it is not well known whether lymphatic spread to lymph node needs
the development of the new lymphatic formation. In addition, the correlation between lymphangiogenesis and prognosis has not
been well documented. This study was designed to assess the prognostic value of lymphangiogenesis and lymphatic vessel invasion
in colorectal cancer.
Methods We examined 106 colorectal cancer specimens by immunostaining for podoplanin, lymphatic endothelial specific marker. We evaluated
lymphangiogenesis, as measured by lymphatic microvessel density, and lymphatic vessel invasion. We next investigated the association
of these two parameters with the clinicopathologic findings and prognosis.
Results A significant correlation was observed between high lymphatic microvessel density and positive lymphatic vessel invasion (P = 0.0003). Positive lymphatic vessel invasion was significantly associated with the presence of lymph node metastasis (P = 0.0071). The survival curves demonstrated that both high lymphatic microvessel density and positive lymphatic vessel invasion
were correlated with an adverse outcome (P = 0.0004 and P = 0.009, respectively). In a univariate analysis, high lymphatic microvessel density and positive lymphatic vessel invasion
were negatively associated with the overall survival (P = 0.0011 and P = 0.0118, respectively). Furthermore, high lymphatic microvessel density, but not lymphatic vessel invasion, correlated with
a poor outcome in a multivariate analysis (P = 0.0114).
Conclusions Our data suggested that lymphatic vessel invasion was related with lymph node metastasis and that both lymphatic microvessel
density and lymphatic vessel invasion were related with an adverse outcome in colorectal cancer. Furthermore, lymphatic microvessel
density may be a useful prognostic factor in colorectal cancer.
*Deceased.
The Poster presentation at the meeting of the Japanese Society of Gastroenterology, Sapporo, Japan, October 11 to 14, 2006.
Reprints are not available. 相似文献
96.
Sachiyo Yoshio Tomonari Shimagaki Ryuki Hashida Takumi Kawaguchi Yuriko Tsutsui Yuzuru Sakamoto Yuichi Yoshida Hironari Kawai Shiori Yoshikawa Taiji Yamazoe Taizo Mori Yosuke Osawa Shinji Itoh Moto Fukai Tomoharu Yoshizumi Akinobu Taketomi Masaki Mori Tatsuya Kanto 《Hepatology research》2021,51(7):803-812
97.
In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), antiprothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE. 相似文献
98.
BACKGROUNDS: Estrogen is known to dilate the coronary vascular system mainly through nitric oxide (NO) release. However, it has not been determined whether or not this effect occurs equally throughout all stages of the female life cycle. We examined the changes in coronary flow properties in adolescent, adult and ovariectomized (OVX) female rats using the endothelial NO synthetase blocker, L-N (omega) nitroarginine (L-NNA). METHODS AND RESULTS: Female rats were divided into 3 groups: adolescent (13 weeks, n=6), adult (19 weeks, n=8) and OVX (20 weeks, n=7, 12 weeks after oophorectomy). Coronary effluent was measured using the Langendorff non-working heart model before and 15 min after the use of L-NNA. In OVX rats, coronary effluent was significantly decreased in comparison with adolescent and adult rats (adolescent vs OVX: p<0.001; adult vs OVX: p<0.05). After treatment with L-NNA, coronary effluent was significantly higher in the adolescent group compared with the adult and OVX groups (adolescent vs adult: p<0.01; adolescent vs OVX: p<0.0005). CONCLUSIONS: Oophorectomy brought about an increase in coronary vascular resistance. L-NNA exacerbated coronary vascular resistance in relation to maturation. It is suggested that the effect of estrogen on vascular dilatation in adolescents is largely dependent on a non-NO pathway, whereas adults are largely dependent on an NO pathway. 相似文献
99.
Studies on common antigenicities were carried out by using rabbit sera immunized with Angiostrongylus cantonensis adult worms or the third stage larvae and antigens of various species of snails and vice versa by the immunoblotting technique. The results obtained are summarized as follows: (1) Common antigenicities between A. cantonensis adult worms and snails susceptible to A. cantonensis were observed in a range of molecular weights of 14.3 to 200 kDa. In Puerto Rican pigmented Biomphalaria glabrata and Achatina fulca, which had high infection rates with A. cantonensis, we recognized 15 to 16 bands against the adult worm, especially the band with a molecular weight of 29 kDa, which had a more intense reaction. (2) Common antigenicities between A. cantonensis third stage larvae and snails susceptible to A. cantonensis, were observed in a range of molecular weights of 14.3 to 97.4 kDa, especially A. fulica and B. glabrata, where we detected many bands in molecular weight range of 18.4 to 43 kDa. Based on the common antigenicities between A. cantonensis and snails susceptible to A. cantonensis, it is possible that the common antigenicities are one of the factors defining the different susceptibilities of various species of snails to A. cantonensis, and more bands are seen with increasing infection rates with A. cantonensis. Of those bands, the protein with the molecular weight of 29 kDa may be the main common antigen between the A. cantonensis adult worm, the third stage larvae and the snails susceptible to A. cantonensis. 相似文献
100.
Yuzuru Yasuda Ichiro Akiguchi Masashi Ino Hidehiko Nabatabe Masakuni Kameyama 《Journal of neurology, neurosurgery, and psychiatry》1990,53(9):797-799
A patient with paramedian thalamic and midbrain infarcts developed palilalia. 相似文献