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71.
Aya Miyazaki MD Hayato Matsutani Yuta Nakano Tadashi Ikeda MD Hideki Uemura MD Hiraku Doi MD 《Pacing and clinical electrophysiology : PACE》2020,43(9):1051-1057
We encountered a unique pattern of cardiac dyssynchrony in a patient with complex congenital heart disease (heterotaxy syndrome) with a biventricular physiology and systemic left ventricle (LV). On speckle tracking echocardiography, dyssynchrony was not detected within the LV, but was noted in an interventricular fashion between the LV and right ventricle (RV). An electrophysiologic study revealed a conduction delay in the subpulmonary RV. Cardiac resynchronization therapy provided reverse cardiac remodeling and an excellent result in our patient by placing the pacing leads around the dyssynchronous lesion. 相似文献
72.
Yuta Yoshizaki Eiji Yuba Naoki Sakaguchi Kazunori Koiwai Atsushi Harada Kenji Kono 《Biomaterials》2014
Cationic lipid-incorporated liposomes modified with pH-sensitive polymers were prepared by introducing 3, 5-didodecyloxybenzamidine as a cationic lipid to egg yolk phosphatidylcholine liposomes modified with 3-methylglutarylated hyperbranched poly(glycidol) (MGlu-HPG) as a pH-sensitive polymer. These liposomes were stable at neutral pH, but were destabilized below pH 6.0 because MGlu-HPG changed its characteristics from hydrophilic to hydrophobic in response to the pH decrease. Cationic lipid inclusion improved their pH sensitivity at weakly acidic pH and association of liposomes with murine dendritic cell (DC) lines. Cationic lipid-incorporated liposomes delivered entrapped ovalbumin (OVA) molecules not only to cytosol but also to endosome/lysosome. Treatment with cationic lipid-incorporated liposomes induced up-regulation of antigen presentation-involved molecules on DCs, the promotion of cytokine production, and antigen presentation via both major histocompatibility complex (MHC) class I and II molecules. Especially, antigen presentation via MHC class II was promoted by cationic lipid inclusion, which might correspond to efficient endosome/lysosome delivery of OVA. Subcutaneous administration of OVA-loaded cationic lipid-incorporated liposomes induced antigen-specific antibody production in serum and Th1-dominant immune responses in the spleen. Furthermore, administration of the cationic lipid-incorporated liposomes to mice bearing E.G7-OVA tumor more significantly reduced the tumor volume than liposomes without cationic lipids. Therefore, cationic lipid inclusion into pH-sensitive polymer-modified liposomes, which can achieve both efficient antigen intracellular delivery and activation of antigen presenting cell, is an effective approach to develop antigen carriers for efficient cancer immunotherapy. 相似文献
73.
Yuta Takeuchi Yuma Ebihara Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Yo Kurashima Soichi Murakami Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Toshiaki Shichinohe Satoshi Hirano 《Asian journal of endoscopic surgery》2020,13(2):215-218
We report a novel technique for combined laparoscopy and thoracoscopy for far‐advanced adenocarcinoma of the esophagogastric junction (AEG). A 56‐year‐old man presented with far‐advanced AEG, and an esophagogastroduodenoscopy revealed a type 2 lesion that encircled the esophagogastric junction. CT revealed stenosis of the esophagogastric junction, suspected invasion into the left side of the diaphragm, and lymph node metastases in the abdomen. We diagnosed Siewert type II AEG (cT4aN1M0, cStage IIIA) according to the Japanese Classification of Gastric Carcinoma, version 14. Laparoscopic and thoracoscopic proximal gastrectomy and lower esophagectomy with double‐tract reconstruction were performed as a palliative resection via a minimally invasive abdominal and left thoracic approach. However, localized peritoneal dissemination was detected. The patient was discharged with no postoperative morbidity. Hence, a minimally invasive abdominal and left thoracic approach provides good visualization, and it is safe for lower esophageal transection and intrathoracic anastomosis in the treatment of locally advanced AEG invading the surrounding tissues. 相似文献
74.
Preeyanuch Junkong Rie Morimoto Kosuke Miyaji Atitaya Tohsan Yuta Sakaki Yuko Ikeda 《RSC advances》2020,10(8):4772
The effect of fatty acids with different aliphatic chain lengths on the accelerated vulcanization reaction of isoprene rubber was investigated through the generation of new intermediates composed of dinuclear bridging bidentate zinc/carboxylate complexes. Using the combination of in situ time-resolved Fourier-transform infrared spectroscopy and in situ time-resolved zinc K-edge X-ray absorption fine structure spectroscopy, the essential complex structure of the intermediates formed during the vulcanization reaction of isoprene rubber was determined to be independent of the aliphatic chain length of fatty acids. However, the reactivity of arachidic acid with ZnO was found to be low, which prolonged the induction period and curing time, and slowed down the curing rate in the vulcanization of isoprene rubber. These results help to understand the complicated vulcanization reaction of rubber, especially natural rubber, which inherently contains various fatty acids. The results obtained in this study are important for developing well-designed high-performance natural rubber products in the future.The effect of fatty acids with different aliphatic chain lengths on the accelerated vulcanization reaction of isoprene rubber was investigated through the generation of new intermediates composed of dinuclear bridging bidentate zinc/carboxylate complexes. 相似文献
75.
Solvate ionic liquids (SILs), comprising long-lived, Li solvate cations and counter anions, serve as highly Li-ion-conductive and non-flammable electrolytes for use in lithium secondary batteries. In this work, we synthesized a series of novel redox-active glyme(oligoether)–Li salt-based SILs, consisting of a symmetric ([Li(G3)]+) or asymmetric ([Li(G3Bu)]+) triglyme–Li salt complex and redox-active tetrahalogenoferrate ([FeX]− (X = Br4, Cl3Br, Cl4)), for use as the catholyte in semi-liquid lithium secondary batteries. The successful formation of stable molten complexes of [Li(G3/G3Bu)][FeX] was confirmed by Raman spectroscopy and thermogravimetry. The melting point (Tm) depended on both the molecular weights of the complex anions and the structures of the complex cations. [Li(G3)][FeCl4] comprised complex cations with a symmetric structure, and the smallest complex anions showed the lowest Tm of 28.2 °C. The redox properties of the [FeX]−/[FeX]2− couple strongly suggested the suitability of [Li(G3/G3Bu)][FeX] as a catholyte. The discharge capacities of semi-liquid lithium secondary batteries utilizing the [Li(G3/G3Bu)][FeX] catholyte depended on the structure of the SILs, and the cell with [Li(G3)][FeCl4] showed the highest capacity with relatively good capacity retention. This study confirmed the feasibility of the glyme-based redox-active SILs as catholytes for scalable redox-flow type batteries.Solvate ionic liquids (SILs), comprising long-lived, Li solvate cations and counter anions, serve as highly Li-ion-conductive and non-flammable electrolytes for use in lithium secondary batteries. 相似文献
76.
Ayako Sakakibara Kei Kohno Eri Ishikawa Yuka Suzuki Yuta Tsuyuki Satoko Shimada Kazuyuki Shimada Akira Satou Taishi Takahara Akiko Ohashi Emiko Takahashi Seiichi Kato Shigeo Nakamura Naoko Asano 《Journal of Clinical and Experimental Hematopathology》2021,61(4):182
The programmed cell death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in tumor cell escape from immune control and has been most extensively investigated for therapeutic purposes. However, PD-L1 immunohistochemistry is still not used widely for diagnosis. We review the diagnostic utility of PD-L1 (by clone SP142) immunohistochemistry in large-cell lymphomas, mainly consisting of classic Hodgkin lymphoma (CHL) and diffuse large B-cell lymphoma (DLBCL). Neoplastic PD-L1 (nPD-L1) expression on Hodgkin and Reed-Sternberg cells is well-established among prototypic CHL. Of note, EBV+ CHL often poses a challenge for differential diagnosis from peripheral T-cell lymphoma with EBV+ non-malignant large B-cells; their distinction is based on the lack of PD-L1 expression on large B-cells in the latter. The nPD-L1 expression further provides a good diagnostic consensus for CHL with primary extranodal disease conceivably characterized by a combined pathogenesis of immune escape of tumor cells and immunodeficiency. Compared with CHL, the nPD-L1 expression rate is much lower in DLBCL, highlighting some specific subgroups of intravascular large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and EBV+ DLBCL. They consist of nPD-L1-positive and -negative subgroups, but their clinicopathological significance remains to be elucidated. Microenvironmental PD-L1 positivity on immune cells may be associated with a favorable prognosis in extranodal DLBCL. PD-L1 (by SP142) immunohistochemistry has helped us to understand the immune biology of lymphoid neoplasms possibly related by immune escape and/or immunodeficiency. However, knowledge of these issues remains limited and should be clarified for diagnostic consensus in the future. 相似文献
77.
John McGrady Yuta Kumagai Masayuki Watanabe Akira Kirishima Daisuke Akiyama Akira Kitamura Shingo Kimuro 《RSC advances》2021,11(46):28940
In the event of nuclear waste canister failure in a deep geological repository, groundwater interaction with spent fuel will lead to dissolution of uranium (U) into the environment. The rate of U dissolution is affected by bicarbonate (HCO3−) concentrations in the groundwater, as well as H2O2 produced by water radiolysis. To understand the dissolution of U3O8 by H2O2 in bicarbonate solution (0.1–50 mM), dissolved U concentrations were measured upon H2O2 addition (300 μM) to U3O8/bicarbonate mixtures. As the H2O2 decomposition mechanism is integral to the dissolution of U3O8, the kinetics and mechanism of H2O2 decomposition at the U3O8 surface was investigated. The dissolution of U3O8 increased with bicarbonate concentration which was attributed to a change in the H2O2 decomposition mechanism from catalytic at low bicarbonate (≤5 mM HCO3−) to oxidative at high bicarbonate (≥10 mM HCO3−). Catalytic decomposition of H2O2 at low bicarbonate was attributed to the formation of an oxidised surface layer. Second-order rate constants for the catalytic and oxidative decomposition of H2O2 at the U3O8 surface were 4.24 × 10−8 m s−1 and 7.66 × 10−9 m s−1 respectively. A pathway to explain both the observed U3O8 dissolution behaviour and H2O2 decomposition as a function of bicarbonate concentration was proposed.A transition from catalytic to oxidative H2O2 decomposition on U3O8 was observed with NaHCO3 with significant implications for uranium dissolution. 相似文献
78.
Tatsuya Watanabe Tamae Yokokawa Mitsuru Yamada Shoudai Kurosumi Shinsaku Ugawa Hojin Lee Yuta Irii Fumihiko Maki Takao Gunji Jianfei Wu Futoshi Matsumoto 《RSC advances》2021,11(59):37150
To produce water-stable Ni-rich lithium nickel cobalt aluminum oxides (LiNixCoyAl1−x−yO2, x > 0.85, NCAs), the formation of trilithium phosphate (Li3PO4)-coated layers on the NCA surfaces was attempted through the use of a surface reaction in a mixture of ethanol and water and a post-heat treatment at 350 and 400 °C. Based on the results of X-ray photoelectron spectroscopy (XPS), the coated layers consisted of nickel phosphate (Ni3(PO4)2) and Li3PO4. The coated NCA surface could have sufficient water stability to maintain the cathode performance in a water slurry for 1 day. In addition, the coated layers formed on the NCA surfaces did not block Li+-ion transfer through the Ni3(PO4)2/Li3PO4-coating layers and enhanced the high-rate discharge performance.To produce water-stable Ni-rich lithium nickel cobalt aluminum oxides, the formation of trilithium phosphate coated layers on the NCA surfaces was attempted through the use of a surface reaction in a mixture of ethanol and water and a post-heat treatment at 350 and 400 °C. 相似文献
79.
Nghiem Nguyet Thu Truong Tuyet Mai Tran Th໋ Thu Trang Nguyen Anh Tuan Tran Chau Quyen Nguyen Lien Hanh Nguyen Huu Hoan Bui Thi Huong Lan Phung Thi Hau Ha Huy Tue Truong Viet Dung Ryohei Tsuji Yuta Watanabe Naoki Yamamoto Osamu Kanauchi 《Nutrients》2022,14(3)
Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 1011 count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID. 相似文献
80.
Harumi Hotta Kazuto Masamoto Sae Uchida Yuta Sekiguchi Hiroyuki Takuwa Hiroshi Kawaguchi Kazuhiro Shigemoto Ryo Sudo Kazuo Tanishita Hiroshi Ito Iwao Kanno 《Journal of cerebral blood flow and metabolism》2013,33(9):1440-1447
To clarify mechanisms through which activation of the nucleus basalis of Meynert (NBM) increases cerebral cortical blood flow, we examined whether cortical parenchymal arteries dilate during NBM stimulation in anesthetized mice. We used two-photon microscopy to measure the diameter of single penetrating arteries at different depths (∼800 μm, layers I to V) of the frontal cortex, and examined changes in the diameter during focal electrical stimulation of the NBM (0.5 ms at 30 to 50 μA and 50 Hz) and hypercapnia (3% CO2 inhalation). Stimulation of the NBM caused diameter of penetrating arteries to increase by 9% to 13% of the prestimulus diameter throughout the different layers of the cortex, except at the cortical surface and upper part of layer V, where the diameter of penetrating arteries increased only slightly during NBM stimulation. Hypercapnia caused obvious dilation of the penetrating arteries in all cortical layers, including the surface arteries. The diameters began to increase within 1 second after the onset of NBM stimulation in the upper cortical layers, and later in lower layers. Our results indicate that activation of the NBM dilates cortical penetrating arteries in a layer-specific manner in magnitude and latency, presumably related to the density of cholinergic nerve terminals from the NBM. 相似文献