全文获取类型
收费全文 | 5721篇 |
免费 | 301篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 92篇 |
儿科学 | 176篇 |
妇产科学 | 188篇 |
基础医学 | 452篇 |
口腔科学 | 169篇 |
临床医学 | 448篇 |
内科学 | 1598篇 |
皮肤病学 | 99篇 |
神经病学 | 314篇 |
特种医学 | 228篇 |
外科学 | 960篇 |
综合类 | 127篇 |
一般理论 | 5篇 |
预防医学 | 402篇 |
眼科学 | 216篇 |
药学 | 351篇 |
中国医学 | 25篇 |
肿瘤学 | 252篇 |
出版年
2024年 | 9篇 |
2023年 | 52篇 |
2022年 | 107篇 |
2021年 | 200篇 |
2020年 | 117篇 |
2019年 | 146篇 |
2018年 | 184篇 |
2017年 | 128篇 |
2016年 | 149篇 |
2015年 | 214篇 |
2014年 | 236篇 |
2013年 | 324篇 |
2012年 | 462篇 |
2011年 | 466篇 |
2010年 | 285篇 |
2009年 | 222篇 |
2008年 | 413篇 |
2007年 | 441篇 |
2006年 | 402篇 |
2005年 | 371篇 |
2004年 | 285篇 |
2003年 | 235篇 |
2002年 | 190篇 |
2001年 | 64篇 |
2000年 | 60篇 |
1999年 | 58篇 |
1998年 | 39篇 |
1997年 | 32篇 |
1996年 | 16篇 |
1995年 | 20篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 14篇 |
1991年 | 21篇 |
1990年 | 15篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 12篇 |
1986年 | 6篇 |
1985年 | 10篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1932年 | 1篇 |
1931年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有6102条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
Apparent mineralocorticoid excess (AME) syndrome is a rare autosomal recessive disorder due to the deficiency of 11β hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2). Mutations in this gene affect the enzymatic activity resulting to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor leading to inherited hypertension. This is a potentially fatal but treatable disorder. We present clinical and molecular studies on two sisters diagnosed as AME. 相似文献
55.
Ashish Soni Pankaj Kumar Das Abdul Wahab Hashmi Mohammad Yusuf Hesam Kamyab Shreeshivadasan Chelliapan 《Sustainable Chemistry and Pharmacy》2022
Strict environmental concern, depletion, and price hike of building construction materials are driving scientific studies for the search of alternative materials for building construction. To this end sustainable building materials could be a fruitful solution. This review aims to discern the environmental efficacy of solid waste management (SWM) and its relationship with four stimuli i.e., economic structure, regulatory structure, science, and time. The study also highlights the investigation of governance network to figure out the regulatory structure and governance of waste management. Extensive details on solid waste with their sources, recycling potential and their current utilization for substantial development are outlined. A throughout of the production process, properties, advantages, disadvantages, and the global economy of building material developed through recycling of solid waste are discussed. This article also deals with the sustainability, social, and environmental impact of green building materials. The study identifies the future direction for the effective utilization of solid waste for developing building materials. Further, the scope of the present also focusses on the concept of circular economy for developing construction materials through recycling of solid waste, which provides an easy reference for solid waste processing towards sustainability. 相似文献
56.
Ali Kamran Benjamin Zendejas Jay Meisner Sukgi S. Choi Carlos Munoz-San Julian Peter Ngo Michael Manfredi Jessica L. Yasuda C Jason Smithers Thomas E. Hamilton Russell W. Jennings 《Journal of the American College of Surgeons》2021,232(5):690-698
- Download : Download high-res image (339KB)
- Download : Download full-size image
57.
58.
59.
60.
Inhibition of the proteasome has emerged as a clinically effective anticancer therapeutic approach in recent years. Bortezomib (Velcade®) showed extremely high potency against a wide range of cancer cell lines. Ixazomib (MLN9708-MLN2238), the second-generation proteasome inhibitor, selectivity and potency were similar to that of bortezomib, is currently being investigated in phase I studies. It shows superior antitumor activity in hematologic malignancy, especially multiple myelomas. In this study, for the first time, we evaluated and compared the antiproliferative and apoptotic effects of the novel proteasome inhibitor MLN2238 (the active form of MLN9708) with bortezomib using in vitro chronic myeloid leukemia. Cytotoxic and apoptotic effects of MLN2238 and bortezomib were determined by trypan blue dye exclusion assays, WST-1 cell proliferation assay, increased AnnexinV-PI binding capacity, changes in caspase-3 activity and loss of mitochondrial membrane potential (JC-1). Associated with proteasome pathway NFκB1 and c-myc mRNA expression levels were examined by the qRT-PCR method. We observed that cytotoxic and apoptotic effects on K562 cells were started at 5?μm of MLN2238 and 1?μm of bortezomib after 24 and 48?h. Also, MLN2238 and bortezomib downregulated NFκB1 and c-myc mRNA expression at 24?h. Our result revealed that MLN22238 and bortezomib had significant cytotoxic and apoptotic effects on K562 cells. Here, we first demonstrate in vitro data that support the development of MLN2238, by direct comparison with bortezomib on K562 cells. 相似文献