排序方式: 共有43条查询结果,搜索用时 0 毫秒
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Jonathan London Antoine Martin Michael Soussan Isabelle Badelon Thomas Gille Yurdagul Uzunhan Bénédicte Giroux-Leprieur Ursula Warzocha Alexis Régent Olivier Galatoire Robin Dhote Sébastien Abad 《Medicine》2015,94(43)
Adult onset asthma and periocular xanthogranuloma (AAPOX) is a rare non-Langerhans histiocytosis characterized histopathologically by a periocular infiltration of foamy histiocytes and Touton giant cells. Benign hyperplasia with plasma cell infiltration is classically described in eyelids or lymph nodes of AAPOX patients. It is also a characteristic feature of IgG4-related disease (IgG4-RD), a new entity defined by an IgG4-bearing plasma cell infiltration of organs.To determine if AAPOX syndrome shares clinical, biological, and histopathological characteristics with IgG4-RD, we used the comprehensive clinical diagnostic criteria for IgG4-RD in a retrospective case series of three consecutive patients with histologically-proven AAPOX. Patients who were diagnosed with AAPOX at a French academic referral center for orbital inflammation between November 1996 and March 2013 were enrolled. Biopsies from ocular adnexa or other organs were systematically reexamined. For each patient, clinical and serological data, radiologic findings, and treatment were retrospectively analyzed.Two AAPOX patients fulfilled all of the diagnostic criteria for a definite IgG4-RD. One patient who lacked the serological criteria fulfilled the criteria of a probable IgG4-RD.These 3 cases of AAPOX patients fulfilled the IgG4-RD comprehensive clinical diagnostic criteria. To our knowledge, this is the first observational case report study to clearly show a strong relationship between IgG4-RD and AAPOX syndrome. 相似文献
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Carla Maldini Raphaèle Seror Olivier Fain Robin Dhote Zahir Amoura Michel De Bandt Jean‐Luc Delassus Géraldine Falgarone Loïc Guillevin Véronique Le Guern François Lhote Olivier Meyer Jacky Ramanoelina Karim Sacré Yurdagul Uzunhan Jean‐Louis Leroux Xavier Mariette Alfred Mahr 《Arthritis care & research》2014,66(3):454-463
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Emel Ahishali Kadir Demir Bulent Ahishali Filiz Akyuz Binnur Pinarbasi Sule Poturoglu Duygu Ibrisim Mine Gulluoglu Sadakat Ozdil Fatih Besisik Sabahattin Kaymakoglu Gungor Boztas Yilmaz Cakaloglu Zeynel Mungan Yurdagul Canberk Atilla Okten 《Journal of gastroenterology and hepatology》2010,25(3):619-626
Background and Aims: Non‐alcoholic fatty liver disease has long been accepted as benign; however, recent evidence suggests that the disease may progress to cirrhosis and hepatocellular carcinoma, although the natural course of the disease is still unclear. This study was designed to comparatively evaluate electron microscopic features of non‐alcoholic fatty liver (NAFL) and non‐alcoholic steatohepatitis (NASH). Methods: Quantitative and semi‐quantitative ultrastructural evaluations were performed on liver biopsies from 23 patients, 10 with NAFL and 13 with NASH. Results: No statistically significant difference was noted between NAFL and NASH patients in ultrastructural features of hepatocytes including megamitochondria, intramitochondrial crystalline inclusions, mitochondrial matrix granules, foamy cytoplasmic appearance, electron‐lucent and glycogen‐containing nuclear regions, lipofuscin granules, or an increased frequency of vesicles containing electron‐dense material in peribiliary Golgi zone; however, the mitochondrial diameter was significantly higher in the NASH patients. Intercellular distance and microvilli between hepatocytes, collagen and electron‐dense material accumulation in the space of Disse, electron‐dense material accumulation and microvillus density in bile canaliculi did not differ significantly between the groups. Conclusions: Our data show that, although NAFL and NASH can be distinguished by their distinct light microscopic features, ultrastructural characteristics are similar, which suggests that NAFL may also have the potential to progress to fibrosis and cirrhosis like NASH. 相似文献
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Jean-Simon Rech Bertrand Arnulf Constance de Margerie-Mellon Alexis Talbot Marion Malphettes Marguerite Vignon Bruno Royer David Lavergne Marianne Kambouchner Véronique Meignin Anne Bergeron Grégoire Prevot Pierre-Yves Brillet Emmanuel Martinod Franck Bridoux Hilario Nunes Arnaud Jaccard Dominique Valeyre Yurdagül Uzunhan 《American journal of hematology》2019,94(11):1214-1226
Lower-respiratory-tract (LRT) amyloidosis has rarely been investigated. Our study presents characteristics, outcomes and survival of LRT amyloidosis. This multicenter retrospective study, from 1995 to 2017, included 73 patients with amyloidosis and LRT involvement. Respiratory patterns were: tracheobronchial (n = 17), nodular (n = 10), interstitial (n = 14) or composite (several respiratory involvements, n = 32). Interstitial and composite patterns were associated with multi-organ amyloidosis (n = 37, 80%) while tracheobronchial and nodular patterns were associated with organ-limited amyloidosis (n = 21, 78%). Amyloid light chain (AL) amyloidosis was diagnosed in 43 patients (59%), mainly of lambda type (n = 33, 77%). Smokers’ proportion was higher in tracheobronchial (71%) and nodular (90%) patterns than in interstitial (14%) and composite (34%) patterns. The B-cell neoplasms involved 15 patients (21%), solid neoplasms 8 (11%), connective tissue diseases 8 (11%) and multiple myeloma 6 (8%). The B-cell and solid neoplasms were most prevalent in nodular pattern. Median follow-up was 4.4 years (2.2-8.9). Twenty-four patients died, mostly from respiratory infection. Survival at 1, 5, 10 years was respectively 88%, 70% and 54% for multi-organ amyloidosis, 96%, 89% and 69% for organ-limited amyloidosis (P = .125). Tracheobronchial and nodular patterns survival was better than in other respiratory patterns (P = .039). Death risk factors (multivariate analysis) were: cardiac localization (hazard-ratio [HR] 4.3 [95% confidence interval 1.6-11.5]; P = .004), age (HR 2.1 [1.2-3.7]; P = .008) and dyspnea at diagnosis (HR 4.0 [1.3-12.3]; P = .014). Various LRT amyloidosis patterns depend on smoking habits, organ-limited or multi-organ extension and comorbidities. They are associated with a different survival, which is also predicted by age, cardiac localization and dyspnea at presentation. 相似文献
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Seray Nural S??an Tu??e Aksu Uzunhan Nur Ayd?nl? Emine Eraslan Bar?? Ekici Mine ?al??kan 《Annals of Indian Academy of Neurology》2013,16(3):342-346