全文获取类型
收费全文 | 3068篇 |
免费 | 337篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 113篇 |
儿科学 | 75篇 |
妇产科学 | 57篇 |
基础医学 | 398篇 |
口腔科学 | 50篇 |
临床医学 | 276篇 |
内科学 | 510篇 |
皮肤病学 | 68篇 |
神经病学 | 318篇 |
特种医学 | 138篇 |
外科学 | 380篇 |
综合类 | 58篇 |
预防医学 | 103篇 |
眼科学 | 57篇 |
药学 | 361篇 |
中国医学 | 47篇 |
肿瘤学 | 469篇 |
出版年
2023年 | 10篇 |
2022年 | 35篇 |
2021年 | 61篇 |
2020年 | 49篇 |
2019年 | 115篇 |
2018年 | 109篇 |
2017年 | 102篇 |
2016年 | 106篇 |
2015年 | 110篇 |
2014年 | 143篇 |
2013年 | 164篇 |
2012年 | 211篇 |
2011年 | 193篇 |
2010年 | 131篇 |
2009年 | 128篇 |
2008年 | 183篇 |
2007年 | 227篇 |
2006年 | 167篇 |
2005年 | 175篇 |
2004年 | 138篇 |
2003年 | 139篇 |
2002年 | 123篇 |
2001年 | 72篇 |
2000年 | 76篇 |
1999年 | 61篇 |
1998年 | 41篇 |
1997年 | 33篇 |
1996年 | 35篇 |
1995年 | 29篇 |
1994年 | 18篇 |
1993年 | 24篇 |
1992年 | 32篇 |
1991年 | 23篇 |
1990年 | 28篇 |
1989年 | 27篇 |
1988年 | 24篇 |
1987年 | 20篇 |
1986年 | 12篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 12篇 |
1981年 | 7篇 |
1980年 | 4篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1971年 | 4篇 |
排序方式: 共有3478条查询结果,搜索用时 15 毫秒
81.
Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu 《Asian journal of andrology》2015,17(5):821-825
We investigated the prostate cancer detection rates upon transrectal ultrasound (TRUS)-guided biopsy in relation to digital rectal examination (DRE) and prostate-specific antigen (PSA), and risk factors of prostate cancer detection in the Chinese population. Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database. The prostate cancer detection rates with reference to DRE finding and PSA level of < 4, 4–10, 10.1–20, 20.1–50 and > 50 ng ml−1 were investigated. Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection. A total of 2606 Chinese men were included. In patients with normal DRE, the cancer detection rates were 8.6%, 13.4%, 21.8%, 41.7% and 85.2% in patients with PSA < 4, 4–10, 10.1–20, 20.1–50 and > 50 ng ml−1 respectively. In patients with abnormal DRE, the cancer detection rates were 12.4%, 30.2%, 52.7%, 80.6% and 96.4% in patients with PSA < 4, 4–10, 10.1–20, 20.1–50 and > 50 ng ml−1 respectively. Older age, smaller prostate volume, larger number of biopsy cores, presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses (P < 0.001). Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population. Taking the different risk factors into account, an individualized approach to the decision of TRUS-guided biopsy can be adopted. 相似文献
82.
83.
84.
Park YH Lee HC Song HG Jung S Ryu SH Shin JW Chung YH Lee YS Suh DJ 《Journal of gastroenterology and hepatology》2003,18(8):927-933
BACKGROUND AND AIM: Recently, antibiotic-resistant microorganisms have been increasingly noted in Korean patients with spontaneous bacterial peritonitis (SBP). The present study investigated the changing pattern of antibiotic resistance and its effects on the clinical outcome in treating SBP. METHODS: The present study retrospectively analyzed 87 episodes of SBP in 1995, 222 in 1998, and 271 in 1999. The isolated microorganisms and their antibiotic susceptibility were compared, and prognostic factors for survival were analyzed. RESULTS: Microorganisms were isolated in 41% of total episodes. The three most frequently isolated organisms were Escherichia coli (48%), Klebsiella pneumoniae (15%), and Aeromonas (8%). Strains that were resistant to cefotaxime in Gram-negative bacilli significantly increased from 7% in 1995 to 28% in 1999, and those to ciprofloxacin increased from 10% to 32%. Treatment failure also increased from 6% to 23%. Combined hepatocellular carcinoma and SBP caused by extended-spectrum beta-lactamase-producing strains were two independent prognostic factors for survival. CONCLUSION: Considering the increase in antibiotic-resistant microorganisms related to SBP, measures to prevent the in-hospital spread of resistant strains and the indiscriminate use of antibiotics should be instituted more stringently. 相似文献
85.
86.
Fa‐Po Chung Ying‐Chieh Liao Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Chin‐Yu Lin Ting‐Yung Chang Jennifer Jeanne B. Vicera Chye‐Gen Chin Cheng‐I Wu Chih‐Min Liu Po‐Tseng Lee Ting‐Chun Huang Isaiah C. Lugtu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(1):9-17
87.
Jennifer Jeanne B. Vicera Yenn‐Jiang Lin Po‐Tseng Lee Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Fa‐Po Chung Chin‐Yu Lin Ting‐Yung Chang Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Cheng‐I Wu Chih‐Min Liu Chung‐Hsing Lin Chieh‐Mao Chuang Chun‐Chao Chen Chye Gen Chin Shin‐Huei Liu Wen‐Han Cheng Le Phat Tai Sung‐Hao Huang Ching‐Yao Chou Isaiah Lugtu Ching‐Han Liu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(6):1436-1447
88.
Chan Ho Kim Hyung Jung Oh Mi Jung Lee Young Eun Kwon Yung Ly Kim Ki Heon Nam Kyoung Sook Park Seong Yeong An Kwang Il Ko Hyang Mo Koo Fa Mee Doh Seung Hyeok Han Tae-Hyun Yoo Beom Seok Kim Shin-Wook Kang Kyu Hun Choi 《Yonsei medical journal》2014,55(1):141-148
Purpose
The effect of different peritoneal dialysis (PD) modalities on the decline in residual renal function (RRF) is unclear due to inconsistencies among studies. In particular, the effect of automated peritoneal dialysis (APD) modalities [continuous cyclic peritoneal dialysis (CCPD) and nightly intermittent peritoneal dialysis (NIPD)] on RRF has not been examined in a large cohort.Materials and Methods
We conducted a single-center retrospective study to investigate the association between PD modalities and decline in RRF in 142 incident PD patients [34 on CCPD, 36 on NIPD, and 72 on continuous ambulatory peritoneal dialysis (CAPD)]. RRF was measured within 2 months from PD start and at 1 year after PD initiation.Results
The RRF at 1 year after PD initiation was 1.98±2.20 mL/min/1.73 m2 in CCPD patients and 3.63±3.67 mL/min/1.73 m2 in NIPD patients, which were moderately lower than 4.23±3.51 mL/min/1.73 m2 in CAPD patients (p=0.064). Moreover, there was no significant difference in the 1-year rate of decline of RRF between CCPD and NIPD patients, although APD patients had a faster 1-year RRF decline rate than CAPD patients (CCPD and NIPD vs. CAPD: -45.68 and -36.69 vs. 1.17%/year, p=0.045). APD was associated with a more rapid decline in RRF in patients with end-stage renal disease undergoing PD, although multivariate analysis attenuated the significance of this finding (β=-31.50; 95% CI, -63.61 to 0.62; p=0.052).Conclusion
Our results suggest that CAPD might be more helpful than APD for preserving RRF during the first year of dialysis therapy, although there was no significant difference in the 1-year rate of decline of RRF between the two APD modalities. 相似文献89.
Laurentiu Zolotusca Pernille Jorgensen Odette Popovici Adriana Pistol Florin Popovici Marc‐Alain Widdowson Viorel Alexandrescu Alina Ivanciuc Po‐Yung Cheng Diane Gross Caroline S. Brown Joshua A. Mott 《Influenza and other respiratory viruses》2014,8(1):8-12
Background
Limited data are available from Central and Eastern Europe on risk factors for severe complications of influenza. Such data are essential to prioritize prevention and treatment resources and to adapt influenza vaccination recommendations.Objectives
To use sentinel surveillance data to identify risk factors for fatal outcomes among hospitalized patients with severe acute respiratory infections (SARI) and among hospitalized patients with laboratory-confirmed influenza.Methods
Retrospective analysis of case-based surveillance data collected from sentinel hospitals in Romania during the 2009/2010 and 2010/2011 winter influenza seasons was performed to evaluate risk factors for fatal outcomes using multivariate logistic regression.Results
During 2009/2010 and 2010/2011, sentinel hospitals reported 661 SARI patients of which 230 (35%) tested positive for influenza. In the multivariate analyses, infection with influenza A(H1N1)pdm09 was the strongest risk factor for death among hospitalized SARI patients (OR: 6·6; 95% CI: 3·3–13·1). Among patients positive for influenza A(H1N1)pdm09 virus infection (n = 148), being pregnant (OR: 7·1; 95% CI: 1·6–31·2), clinically obese (OR: 2·9;95% CI: 1·6–31·2), and having an immunocompromising condition (OR: 3·7;95% CI: 1·1–13·4) were significantly associated with fatal outcomes.Conclusion
These findings are consistent with several other investigations of risk factors associated with influenza A(H1N1)pdm09 virus infections. They also support the more recent 2012 recommendations by the WHO Strategic Advisory Group of Experts on Immunization (SAGE) that pregnant women are an important risk group for influenza vaccination. Ongoing sentinel surveillance can be useful tool to monitor risk factors for complications of influenza virus infections during each influenza season, and pandemics as well. 相似文献90.
Ann Moen Pamela J. Kennedy Po‐Yung Cheng Goldie MacDonald 《Influenza and other respiratory viruses》2014,8(2):201-208