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101.
Nobuhiro Takemae Tung Nguyen Long Thanh Ngo Yasuaki Hiromoto Yuko Uchida Vu Phong Pham Tsutomu Kageyama Shizuko Kasuo Shinichi Shimada Yasutaka Yamashita Kaoru Goto Hideyuki Kubo Vu Tri Le Hung Van Vo Hoa Thi Do Dang Hoang Nguyen Tsuyoshi Hayashi Aya Matsuu Takehiko Saito 《Archives of virology》2013,158(4):859-876
The antigenicity of the influenza A virus hemagglutinin is responsible for vaccine efficacy in protecting pigs against swine influenza virus (SIV) infection. However, the antigenicity of SIV strains currently circulating in Japan and Vietnam has not been well characterized. We examined the antigenicity of classical H1 SIVs, pandemic A(H1N1)2009 (A(H1N1)pdm09) viruses, and seasonal human-lineage SIVs isolated in Japan and Vietnam. A hemagglutination inhibition (HI) assay was used to determine antigenic differences that differentiate the recent Japanese H1N2 and H3N2 SIVs from the H1N1 and H3N2 domestic vaccine strains. Minor antigenic variation between pig A(H1N1)pdm09 viruses was evident by HI assay using 13 mAbs raised against homologous virus. A Vietnamese H1N2 SIV, whose H1 gene originated from a human strain in the mid-2000s, reacted poorly with post-infection ferret serum against human vaccine strains from 2000-2010. These results provide useful information for selection of optimal strains for SIV vaccine production. 相似文献
102.
Ogura Sho Kimura Muneyoshi Takagi Shinsuke Mitsuki Takashi Yuasa Mitsuhiro Kageyama Kosei Kaji Daisuke Nishida Aya Taya Yuki Ishiwata Kazuya Yamamoto Hisashi Asano-Mori Yuki Yamamoto Go Uchida Naoyuki Wake Atsushi Taniguchi Shuichi Araoka Hideki 《European journal of clinical microbiology & infectious diseases》2021,40(5):941-948
European Journal of Clinical Microbiology & Infectious Diseases - The aim of this study is to clarify the characteristics of gram-negative bacteremia (GNB), including extended-spectrum... 相似文献
103.
Keiko Hijiya Yuji Masuda Takeshi Miyamoto Ryosuke Shimono Takafumi Kato Toru Kageyama Kazuhiro Yamada 《Journal of oral biosciences / JAOB, Japanese Association for Oral Biology》2021,63(2):210-216
ObjectivesDeterioration of lip function in the elderly is a form of oral hypofunction. It is important to understand age-related changes in lip function to improve oral health. This study aimed to quantitatively compare the maximum lip-closing force (LCF) and the ability to control LCF during voluntary lip-pursing movements between elderly and young adults and clarify the influence of aging on both measurements.MethodsUsing a multidirectional LCF measurement system, we measured six-directional maximum LCFs (upper, upper right, lower right, lower, lower left, upper right) of 20 healthy elderly men (69.6 ± 4.2 years) and 20 healthy young men (25.1 ± 3.8 years). The ability to control the LCF in each direction was assessed based on the accuracy rate. The directional LCF and the ability to control LCF were compared between the elderly and young adults.ResultsThe maximum directional LCF in the elderly adults was significantly smaller than that in the young adults in three directions from the lower lip; moreover, the accuracy rate of the elderly adults was significantly lower than that of young adults in five of the six directions.ConclusionsOur findings suggest that the influence of aging on the accuracy of LCF may be different from that on muscle strength. Hypofunction of the lips due to aging may result not only from decreased muscle strength but also from reduced LCF accuracy. 相似文献
104.
105.
M. Edama H. Onishi K. Kumaki I. Kageyama H. Watanabe S. Nashimoto 《Scandinavian journal of medicine & science in sports》2015,25(2):242-250
Muscle injury frequently occurs in the medial head of the gastrocnemius (MG), and stretching is used for treatment. However, there are no studies based on anatomical considerations and biomechanics. This study therefore examined the macroscopic anatomical structure of the triceps surae muscle to design an effective and selective MG stretching method, before quantitatively verifying that method by ultrasonography. The macroscopic anatomy was analyzed in 16 Japanese cadavers (25 legs). Based on the anatomical findings and the arrangement of fascicles in the MG, we concluded that ankle inversion might be advantageous for selective stretching of the tendon fiber bundles into which the MG inserts. We devised a method in which the limb was initially positioned with the knee joint in extension and the ankle joint in plantar flexion. Then, the ankle was dorsiflexed and inverted. The proposed method was compared with standard stretching and verified by ultrasonography in eight healthy adult males. This method effectively and selectively stretched the MG, producing a significantly decreased pennation angle and increased muscle fiber length. This method may be beneficial for preventing future injuries and may enhance the effect of therapy on the MG. 相似文献
106.
107.
Novel image monitoring system using a head‐mounted display for assistants in da Vinci surgery
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108.
Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin
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Ryuzo Kawamori Kohei Kaku Toshiaki Hanafusa Katsuhisa Ioriya Shigeru Kageyama Nigishi Hotta 《Journal of diabetes investigation.》2016,7(2):253-259
Aims/Introduction
The aim of the present study was to evaluate the long‐term efficacy and safety of adding repaglinide in patients with type 2 diabetes mellitus whose blood glucose levels were not sufficiently controlled by treatment with a dipeptidyl peptidase‐4 inhibitor, sitagliptin, in addition to diet and exercise therapies.Materials and Methods
This was a multicenter, uncontrolled, dose‐titration study with a treatment period of 52 weeks. The primary end‐point was the change in glycated hemoglobin levels from baseline.Results
The glycated hemoglobin level was 7.43 ± 0.57% (mean ± standard deviation) at baseline, and decreased to 6.93 ± 0.91% at the end of the study. The mean changes in glycated hemoglobin levels at 4 weeks and at the end of the study were −0.44 ± 0.28% and −0.50 ± 0.82%, respectively. The glycated hemoglobin‐lowering effect was maintained for 52 weeks. The rate of adverse events was 86.0% (86/100), and there were 352 adverse events. The rate of adverse drug reactions was 21.0% (21/100). Hypoglycemia was reported in 5.0% (5/100) of patients, but there was no incidence of ‘major hypoglycemia’.Conclusions
Combination therapy with repaglinide and sitagliptin was considered effective for a long term without clinical safety problems in patients with type 2 diabetes mellitus. 相似文献109.
Torikai E Kageyama Y Suzuki M Ichikawa T Nagano A 《Modern rheumatology / the Japan Rheumatism Association》2008,18(5):486-491
It has been reported that nearly 90% of patients with rheumatoid arthritis (RA) have problems with their feet. Several methods
of treating hallux valgus deformity in RA have previously been reported, including arthrodesis and joint resection, and good
results have been observed with surgical procedures. In this report, we compare the clinical and radiological outcomes of
resection arthroplasty alone (the first method) and resection arthroplasty with arthrodesis of the first MTP joint (the second
method) for the treatment of forefoot deformities of RA patients. On clinical assessment, the American Orthopaedic Foot and
Ankle Society (AOFAS) scale score significantly improved in both methods; however, the second method gave better results than
the first method in relation to the footwear and alignment components. On radiographic assessment, in the first method there
were no significant changes in the valgus angle (H–V angle) and the fifth metatarsal bone (M1/5) angle between preoperation
and last follow-up. In contrast, these angles were decreased in the second method. One of the most important issues in the
treatment of forefoot deformities in RA patients is to correct splaying foot deformity. We believe that the second method,
which can correct splaying foot deformity, is currently the most reliable treatment method. 相似文献
110.
Tomohiko Imamura Yuji Tanaka Yumiko Ninomiya Masao Yoshinaga 《Pediatrics international》2015,57(4):716-718
Congenital junctional ectopic tachycardia is a rare tachyarrhythmia with high mortality. A pharmacological approach in early infancy is regarded as the first‐line therapeutic option. Pharmacologically, amiodarone alone or in combination with other drugs is the most commonly reported effective agent for congenital junctional ectopic tachycardia, but it has many adverse effects. Here we report the case of a 40‐day‐old infant. The clinical course suggests that combined oral flecainide and propranolol is an effective alternative therapy for early infants. Esophageal lead electrocardiography may give a clear diagnosis of junctional ectopic tachycardia. 相似文献