全文获取类型
收费全文 | 3087篇 |
免费 | 173篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 153篇 |
妇产科学 | 59篇 |
基础医学 | 358篇 |
口腔科学 | 57篇 |
临床医学 | 163篇 |
内科学 | 685篇 |
皮肤病学 | 60篇 |
神经病学 | 164篇 |
特种医学 | 108篇 |
外科学 | 727篇 |
综合类 | 12篇 |
预防医学 | 56篇 |
眼科学 | 101篇 |
药学 | 243篇 |
中国医学 | 31篇 |
肿瘤学 | 284篇 |
出版年
2024年 | 2篇 |
2023年 | 18篇 |
2022年 | 36篇 |
2021年 | 89篇 |
2020年 | 43篇 |
2019年 | 70篇 |
2018年 | 88篇 |
2017年 | 79篇 |
2016年 | 75篇 |
2015年 | 99篇 |
2014年 | 123篇 |
2013年 | 134篇 |
2012年 | 184篇 |
2011年 | 235篇 |
2010年 | 109篇 |
2009年 | 119篇 |
2008年 | 182篇 |
2007年 | 221篇 |
2006年 | 185篇 |
2005年 | 203篇 |
2004年 | 217篇 |
2003年 | 173篇 |
2002年 | 192篇 |
2001年 | 33篇 |
2000年 | 33篇 |
1999年 | 29篇 |
1998年 | 30篇 |
1997年 | 31篇 |
1996年 | 27篇 |
1995年 | 26篇 |
1994年 | 18篇 |
1993年 | 13篇 |
1992年 | 14篇 |
1991年 | 19篇 |
1990年 | 19篇 |
1989年 | 14篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1976年 | 4篇 |
1969年 | 3篇 |
1968年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有3286条查询结果,搜索用时 218 毫秒
101.
Yoshimura Y Tachikawa N Oosawa T Kosuge Y Kamei K 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2012,86(3):291-294
Paracoccidioidomycosis (PCM) is the most common systemic fungal disease in central-south America, but is rare in Japan. We experiensed a case of PCM in a patient, who came from Bolivia and presented with mouth pain and reduced dietary intake but no fever. Adrenal insufficiency was diagnosed with extremely high serum adrenocorticotropic hormone (ACTH) and was resolved with hormone supplementation. The PCM was treated with trimethoprim-sulfamethoxazole which was switched to itraconazole and improvement was achieved. 相似文献
102.
103.
104.
Yukihiro Iida Masato Matsuoka Ichirou Shimizu Takashi Wakisaka Akitoshi Katsumata 《Oral Radiology》2013,29(1):56-63
Objectives
We examined the usefulness of micro-computed tomography (micro-CT) to measure the distributions of contrast media in materials that simulated the properties of test foods for videofluoroscopic (VF) swallowing studies (VFSS).Methods
Food samples that simulated rice, rice gruel, custard pudding, udon noodles, and liquids were prepared with barium sulfate and iodine contrast media. These samples and simulated foods containing no contrast medium were subjected to micro-CT. The micro-CT scanning was performed using a ScanXmate-RB090SS. Each sample was used to fill a cylindrical container with an inner diameter of 8 mm and a height of 35 mm or a 1-mL plastic syringe, and images were acquired at a voltage of 90 kV, current of 45 μA, and magnification power of 2.5. From the acquired data, 610 × 610-pixel 8-bit image slices were prepared and observed using OsiriX software. The image densities (pixel values) were measured for regions of interest. The obtained pixel values were then normalized on the basis of the density of the barium sulfate contrast medium and water.Results
The infiltration or distributions of the contrast media in the VF test materials were successfully observed, and their values ranged widely compared with the barium sulfate contrast medium.Conclusions
Micro-CT imaging was capable of numerically presenting or visualizing the density and distribution of VF test materials, thereby showing its usefulness as an objective evaluation method. Using this technique, it may be possible to adjust test foods to the optimum contrast properties for clinical VF examinations. 相似文献105.
Atsushi Okada Takahiro Yasui Kazumi Taguchi Kazuhiro Niimi Yasuhiko Hirose Shuzo Hamamoto Ryosuke Ando Yasue Kubota Yukihiro Umemoto Keiichi Tozawa Shoichi Sasaki Yutaro Hayashi Kenjiro Kohri 《Urological research》2013,41(6):487-492
To evaluate the efficacy of company-initiated training of urologists on shock wave lithotripsy (SWL) treatment results, we retrospectively assessed 602 patients who underwent SWL in Nagoya City University Hospital between January 2004 and June 2011 using Lithotripter S (Dornier MedTech, Japan). Training—provided by a training specialist of the company in June 2010—focused on the targeting of renal and proximal ureter stones with a combination of radiography and ultrasonography (US). The stretcher wedges were positioned in the semi-prone position or the semi-supine position for middle and distal ureter stones, respectively. Success rates between 519 pre-training treatments and 83 post-training treatments were compared. Patient age and stone location, burden, number, and composition did not significantly differ between pre- and post-training. Training improved the overall success rate from 66.3 to 87.2 % (P < 0.0001). The mean number of SWL treatments decreased from 1.8 ± 1.8 to 1.4 ± 1.3 (P = 0.01). The first SWL treatment success rate increased from 67.1 to 83.7 % (P = 0.002), and the need for multiple treatments decreased. The frequency of detection of renal and proximal ureter stones by both radiography and US increased from 10.5 % before training to 58.2 % after training (P < 0.0001). Significant factors for successful SWL were determined to be training and prone position for distal ureter stones by multivariate analysis and ultrasonic detection for renal and proximal ureter stones by univariate analysis. Skills in targeting stones using ultrasonography and selecting the proper therapeutic position are essential for improving the success rate of stone removal. 相似文献
106.
Ikemoto T Hojo Y Kondo H Takahashi N Hirose M Nishimura Y Katsuki T Shimada K Kario K 《Heart and vessels》2012,27(4):344-351
Recent clinical studies have revealed that the expression of endoglin, an accessory protein for the TGF-β receptor, is increased in patients with atherosclerotic diseases. The plasma endoglin level is thought to represent endothelial activation, inflammation, and senescence. To clarify the significance of plasma endoglin in chronic coronary artery disease. Human umbilical vein endothelial cells (HUVECs) were cultured to examine changes in soluble endoglin (s-endoglin) levels caused by atherogenic stimulation in vitro. We studied 318 patients with stable coronary artery disease who underwent a successful percutaneous coronary intervention (PCI). Patients with acute coronary syndrome were excluded. Major adverse cardiovascular events (MACE) were congestive heart failure, acute myocardial infarction, stroke, and sudden cardiac death. All patients were followed-up to examine MACE after the procedure. We confirmed that the levels of s-endoglin was increased in the culture medium of HUVECs by senescence, tumor necrosis factor-α and hydrogen peroxide. In a clinical study, mean follow-up period was 1055?±?612?days (49–2136?days) with 27 incidents of MACE (8.5%). We divided patients into three groups according to the plasma s-endoglin levels. Kaplan–Meier curves revealed that the highest endoglin group had a significantly higher MACE rate than the lowest endoglin group (log-rank test, p?=?0.009). A Cox proportional hazards model showed that chronic kidney disease, left ventricular ejection fraction and s-endoglin level were significant factors to predict MACE. Plasma endoglin could be a marker to predict cardiovascular events in patients with chronic coronary artery disease after PCI. 相似文献
107.
108.
Keisuke Uehara Yuichiro Yoshioka Tomoki Ebata Yukihiro Yokoyama Masanao Nakamura Naoki Ohmiya Hidemi Goto Masato Nagino 《Surgery today》2013,43(9):1062-1065
The clinical introduction of double-balloon endoscopy (DBE) has brought about a revolution in the diagnosis and the treatment of diseases of the small intestine. DBE allows not only direct observation of the entire small intestine, but also interventional therapies, tissue sampling and India ink marking (tattooing). Single incision laparoscopic surgery (SILS) was developed from conventional laparoscopic surgery to further reduce the degree of invasiveness. SILS requires only one umbilical incision, thus resulting in almost scarless surgery. This report presents three cases of small intestinal bleeding successfully treated by SILS following tattooing under DBE. The average operative time was 67 min and average blood loss was 5 ml. All patients immediately recovered without any complications. SILS, in conjunction with presurgical tattooing by DBE for small intestinal bleeding is considered to be an ideal approach in terms of minimal surgical trauma and aesthetics. 相似文献
109.
Shunji Tsutsui Ryohei Kagotani Hiroshi Yamada Hiroshi Hashizume Akihito Minamide Yukihiro Nakagawa Hiroshi Iwasaki Munehito Yoshida 《European spine journal》2013,22(9):2010-2014
Introduction
Decompression with fusion is usually recommended in patients with lumbar spinal stenosis (LSS) combined with degenerative lumbar scoliosis (DLS). However, elderly patients with LSS and DLS often have other comorbidities, and surgical treatment must be both safe and effective. The aim of this study was to investigate whether decompression surgery alone alleviates low back pain (LBP) in patients with LSS and DLS, and to identify the predictors of postoperative residual LBP.Materials and methods
A total of 75 patients (33 males and 42 females) with a mean age of 71.8 years (range 53–86 years) who underwent decompression surgery for LSS with DLS (Cobb angle ≥ 10°) and had a minimum follow-up period of 1 year, were retrospectively reviewed using the Japanese Orthopaedic Association scoring system for the assessment of lumbar spinal diseases (JOA score). Radiographic measurements included coronal and sagittal Cobb angles, apical vertebral rotation (Nash-Moe method), and anteroposterior and lateral spondylolisthesis. Logistic regression analysis was performed to investigate the predictors of residual LBP after surgery.Results
Forty-nine patients had preoperative LBP, of which 29 (59.1 %) experienced postoperative relief of LBP. Logistic regression analysis demonstrated that the degree of apical vertebral rotation on preoperative radiography was significantly associated with postoperative residual LBP (odds ratio, 8.16, 95 % confidence interval, 1.55–83.81, p = 0.011).Conclusion
A higher degree of apical vertebral rotation may therefore be an indicator of mechanical LBP in patients with LSS and DLS. Decompression with fusion should be recommended in these patients. 相似文献110.