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排序方式: 共有779条查询结果,搜索用时 171 毫秒
31.
Yuri Nagamine Urata Eduardo Carneiro de Lyra Maria Lucia Hirata Katayama Ricardo Alves Basso Paulo Eduardo Zuccolotto de Assis Ana Paula Torres Cardoso Rosimeire Aparecida Roela Suely Nonogaki João Carlos Guedes Sampaio Góes M. Mitzi Brentani Maria Aparecida Azevedo Koike Folgueira 《Clinical nutrition (Edinburgh, Scotland)》2014
32.
Michio Shimabukuro Satoshi Higa Tatsushi Shinzato Hisashi Yoshida Fumio Nagamine Kiyoshi Takashiba Nobuyuki Takasu 《Catheterization and cardiovascular interventions》1996,39(1):103-105
We report on an unusual patient with a threatened occlusive dissection, in whom prolonged (48-hr) inflation of a balloon catheter with localized heparin infusion proved successful. This intracoronary infusion catheter maintained distal coronary flow on a unique spiral coil design, and may provide an alternative or a bridge to emergency operation or stent implantation. © 1996 Wiley-Liss, Inc. 相似文献
33.
Nobuhiro Koyanagi Kiyoshi Inokuchi Kazushige Beppu Kenji Nagamine Makoto Hashizume Keizo Sugimachi 《Surgery today》1985,15(2):134-139
The time of appearance of the left gastric vein on serial celiac arteriograms in patients with portal hypertension and esophageal
varices was compared with that of the portal vein to assess regional hemodynamics in the left venous portion of the stomach,
an area located in close proximity to the varices. In two thirds of all the patients with cirrhosis or non-cirrhotic idiopathic
portal hypertension (IPH), the left gastric vein was visualized earlier or simultaneously than or with the portal vein, while
in all but one patient with prehepatic portal obstruction, there was a delayed opacification of the left gastric vein. These
results suggest the presence of a hyperdynamic circulatory state which promotes venous hypertension in the left gastric venous
area of the stomach of a considerable number of patients with cirrhosis or IPH. In such a hemodynamic state, selective decompression
of varices can be achieved by a left gastric venous caval shunt. 相似文献
34.
Control of expression of Agrobacterium vir genes by synergistic actions of phenolic signal molecules and monosaccharides 总被引:26,自引:1,他引:26 下载免费PDF全文
Shimoda N Toyoda-Yamamoto A Nagamine J Usami S Katayama M Sakagami Y Machida Y 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(17):6684-6688
Most virulence (vir) genes of Agrobacterium tumefaciens that are required for the formation of crown gall tumors are expressed in response to such plant signal molecules as acetosyringone and lignin precursors. The phenolic signals are transduced through a receptor VirA protein in the inner membrane of the bacterial cell. The expression of these genes triggers the transfer of a specific DNA segment, called transferred DNA (T-DNA), from the Ti plasmid to plant cells, and its integration into their nuclear DNA. We show here that a group of aldoses (L-arabinose, D-xylose, D-lyxose, D-glucose, D-mannose, D-idose, D-galactose, and D-talose) can markedly enhance acetosyringone-dependent expression of vir genes when the concentration of acetosyringone is limited (10 microM) but does not enhance the expression of noninducible genes. Likewise, a 2-deoxy-D-glucose, a nonmetabolized sugar, is also effective. When a deletion was introduced into the virA gene in the region encoding the periplasmic portion of the VirA protein, enhancement by glucose disappeared, but vir expression was induced by acetosyringone in this mutant. These results suggest that these sugars directly enhance a signaling process initiated by phenolic inducers that results in an increase in expression of the vir genes. 相似文献
35.
Masanori Daibata Yuiko Nemoto Kentaro Bandobashi Norihiro Kotani Masayuki Kuroda Mutsumi Tsuchiya Heiwa Okuda Tetsuya Takakuwa Shosuke Imai Taro Shuin Hirokuni Taguchi 《Clinical cancer research》2007,13(12):3528-3535
PURPOSE: Bone morphogenetic proteins (BMP), belonging to the transforming growth factor-beta superfamily, are important regulators of cell growth, differentiation, and apoptosis. The biological effects of BMPs on malignant lymphoma, however, remain unknown. Promoter methylation of the BMP-6 gene in lymphomas was investigated. EXPERIMENTAL DESIGN: We investigated BMP-6 promoter methylation and its gene expression in various histologic types of 90 primary lymphomas and 30 lymphoma cell lines. The effect of BMP-6 promoter hypermethylation on clinical outcome was also evaluated. RESULTS: BMP-6 was epigenetically inactivated in subsets of lymphomas. The silencing occurred with high frequency in diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphoma in association with aberrant BMP-6 promoter methylation. The methylation was observed in 60% (21 of 35) of DLBCL cases and 100% (7 of 7) of DLBCL cell lines, and in 83% (5 of 6) of Burkitt's lymphoma cases and 86% (12 of 14) of Burkitt's lymphoma cell lines. In contrast, other histologic types of primary lymphomas studied had little or no detectable methylation (1 of 49; 2%). The presence of BMP-6 promoter hypermethylation in DLBCL statistically correlated with a decrease in disease-free survival (P = 0.014) and overall survival (P = 0.038). Multivariate analysis showed that the methylation profile was an independent prognostic factor in predicting disease-free survival (P = 0.022) and overall survival (P = 0. 046). CONCLUSION: BMP-6 promoter was hypermethylated more often in aggressive types of lymphomas, and the hypermethylation is likely to be related to the histologic type of lymphomas. BMP-6 promoter methylation may be a potential new biomarker of risk prediction in DLBCL. 相似文献
36.
From a study to find anti-parasitic agents from natural resources, we found that curcumin showed the cytotoxicity against leishmania in vitro. The LD50 value of this activity was 37.6+/-3.5 microM. 相似文献
37.
Abdul Manan Bhutto Kayo Taira Yasushi Nagamine Motoyoshi Maruno Atsushi Takamiyagi Shigeo Nonaka 《The Journal of dermatology》1995,22(2):107-110
A young Japanese man developed localized trichorrhexis nodosa (LTN) of the scalp hair in the winter season. To investigate the roles of shampoo, severe sunlight exposure and/or mechanical injuries, we performed the following studies. Hair was collected from the patient and from a control. The study was performed in two steps. In the first step, hair was put into shampoo, rinsed with saline water, and then exposed to ultraviolet B (UVB) radiation once a day for one week. In the second step, the hair was similarly treated, but each shaft was bent gently with forceps before UVB exposure. Scanning electron microscopic studies revealed cuticular changes when the hair was treated only with shampoo and UVB. When it was treated with shampoo, UVB, and mechanical bending, the patient's hair developed longitudinal and transverse fractures of the hair shafts, while the control hair showed only partial damage to the hair shaft. On the basis on the above findings, we conclude that mechanical bending may damage the hair shaft. 相似文献
38.
39.
Male Fischer 344 rats initiated with 1,2-dimethylhydrazine 2HCl (100 mg/kg) given 18 hr after partial hepatectomy and exposed to a diet containing 1% orotic acid for 13 months developed a 100% incidence of hepatocellular carcinoma. The creation of nucleotide pool imbalances by dietary orotic acid, for e.g., an increase in uridine nucleotides and a decrease in adenine nucleotides, was considered as a possible mechanism for the promotional effect of orotic acid on liver carcinogenesis. The significance of this hypothesis is that altered nucleotide pools affect both genomic as well as membrane organization. Consistent with this hypothesis is our finding that feeding rats with a diet containing 1% orotic acid for 10 weeks resulted in a liver DNA damage as monitored by its slower sedimentation in alkaline sucrose gradients compared to the corresponding controls. To assess the general applicability of this hypothesis, nucleotide pool imbalances were created by using methods other than feeding orotic acid and their effect on the incidence of gamma-glutamyltransferase positive foci in carcinogen initiated rats was determined. The results obtained indicated that rats initiated with 1,2-dimethylhydrazine.2HCl (100 mg/kg) given 18 hr after partial hepatectomy and exposed to diet deficient in arginine, a regimen that causes an increased synthesis and excretion of orotic acid, or were fed diets containing 1% thymidine or 1% thymine developed greater number of gamma-glutamyltransferase positive foci compared to the corresponding controls fed the basal diets. These results were interpreted to indicate that orotic acid exerts its promotional effect probably by creating an imbalance in nucleotide pools. One of the mechanisms by which an imbalance of nucleotide pools influences the pathogenesis of the carcinogenic process may be by inducing perturbations in the DNA. 相似文献
40.
Takashima I Seto Y Nagamine I Kegoya Y Kodoi A Nakayama H 《Gan to kagaku ryoho. Cancer & chemotherapy》2005,32(4):503-505
A 72-year-old woman underwent total gastrectomy for CA19-9 producing gastric cancer. TS-1 was administered for recurrent gastric cancer because the duodenal stump was histologically positive and the serum CA19-9 level elevated after temporary regression. The dose was reduced from 80 mg/body/day to 50 mg/body/day because of grade 3 neutropenia. One course consisted of consecutive administration for 28 days followed by 14 days' rest. Upon the completion of the second course, the serum CA19-9 level became within normal limits, and no recurrence nor remarkable adverse reaction has been recognized for 6 courses. Adjuvant use of TS-1 for gastric cancer is ongoing as clinical trials, however, the incidence of adverse reaction does not seem to be negligible with administration of the recommended dose. Low-dose administration of TS-1 is thought to be one effective method of postoperative adjuvant chemotherapy for gastric cancer. 相似文献