活血化瘀法治疗老年人难治性高血压临床观察

[目的]探讨中药活血化瘀法治疗老年人难治性高血压的临床疗效。[方法]通过对使用西药治疗难治性高血压效果欠佳的老年患者,结合中药活血化瘀辨证治疗,观察疗效。[结果]中西医结合治疗在血压下降幅度、理想降压率等方面取得良好效果,能更有效地降血压。[结论]中药活血化瘀法治疗老年人难治性高血压有良好的效果。     

中药治疗足跟痛79例临床观察

足跟痛是一种常见病症,笔者经过长期临床实践,对该病的病因有了一些新的看法和认识,并摸索出了一种比较有效的治疗方法,现将体会介绍如下.     

Effect of berberine on the pharmacokinetics of substrates of CYP3A and P‐gp

The in vivo effects of berberine (BBR), the widely used bioactive herbal ingredient from many traditional Chinese medicinal herbs, on the pharmacokinetics of carbamazepine (CBZ, a substrate of CYP3A) and its metabolite carbamazepine 10,11‐epoxide (ECBZ), digoxin (DIG, a substrate of P‐gp) and cyclosporine A (CsA, a dual substrate of CYP3A and P‐gp) were evaluated in rats. After a 2‐week pretreatment with BBR, the pharmacokinetic parameters of i.g. administered CBZ and ECBZ were not significantly altered. The pharmacokinetics of i.v. administered DIG was not modified by single and 2‐week pretreatments with BBR, but a dose‐dependent increase in AUC and C_max was observed in the i.g. administered DIG parameters in rats. The AUCs of DIG with BBR (30 mg/kg, 100 mg/kg) were 133%, 170% (single) and 123%, 169% (2‐week) of control, respectively. The AUC and C_max of i.g. administered CsA with a 2‐week pretreatment with BBR increased by 62% and 43% (BBR 30 mg/kg, p < 0.05), 96% and 60% (BBR 100 mg/kg, p < 0.01), compared with the control. In conclusion, berberine produced a dose‐dependent increased bioavailability of digoxin and cyclosporine A by inhibition of intestinal P‐gp. No significant changes in CYP3A activity by berberine were observed. Copyright © 2009 John Wiley & Sons, Ltd.     

榆耳多糖对动物免疫功能的影响

目的：研究榆耳多糖对动物免疫功能的影响。方法：通过体外培养淋巴细胞增殖试验,快速免疫比浊法测定免疫球蛋白G、A、M的含量试验;对大鼠免疫器官脾脏重量的影响试验,证明其免疫提高作用。结果：高剂量组与对照组相比,淋巴细胞增殖试验有显著差异（P〈0．01）,体液免疫实验及免疫器官脾脏重量试验有显著性差异（P〈0．05）。结论：榆耳多糖具有提高动物免疫力的作用。     

温针灸结合手法治疗椎动脉型颈椎病32例观察

目的：观察大椎穴温针灸结合手法治疗椎动脉型颈椎病的疗效。方法：治疗组32例采用大椎穴温针灸结合手法治疗,对照组30例用电针夹脊穴治疗。每周治疗6次,12天为一疗程。治疗2个疗程后观察疗效。结果：治疗组总有效率93．75％,对照组80．00％,两组比较有显著性差异（P〈0．05）。结论：大椎穴温针灸结合手法治疗椎动脉型颈椎病疗效明显。     

胺碘酮在心脏瓣膜病术后心律失常的应用

目的:观察胺碘酮治疗心脏瓣膜病手术后心律失常的治疗结果。方法:总结分析60例风湿性心瓣膜病术后出现室性或快速室上性心律失常患者应用胺碘酮的疗效及安全性。结果:胺碘酮治疗后有效率为91.7%,能较好地控制心率,且对血压影响不明显。结论:胺碘酮治疗心脏瓣膜病手术后室性或快速室上性心律失常的疗效较好。     

西咪替丁治疗小儿毛细支气管炎的临床分析

目的:评价西咪替丁治疗小儿毛细支气管炎的疗效。方法:将108例毛细支气管炎患儿随机分为对照组和治疗组,对照组采用综合抗病毒治疗,治疗组在此基础上加用西咪替丁治疗。结果:喘憋消失、气促缓解、哮鸣音消失及平均住院时间等指标治疗组与对照组比较明显缩短。治疗组和对照组比较总有效率有显著性差异(P<0.01)。结论:抗病毒综合治疗联合西咪替丁治疗小儿毛细支气管炎能增强疗效,缓解症状,缩短病程,提高治愈率。     

中药制剂口服吸收生物利用度改善方法探讨

本文通过文献研究并结合实验室工作成果,以中药活性成分口服吸收机制为出发点,提出通过改善难溶性中药活性成分的溶解度和溶出速度、控制中药活性成分在胃肠道中代谢、改善中药活性成分的胃肠吸收和转运、发挥中药组合活性成分之间的有益影响等方式提高中药活性成分的口服吸收生物利用度.