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31.
A Batak Indonesian from North Sumatra with hemoglobin (Hb) D Punjab (alpha 2 beta 2 121----Gln) and hemoglobin Constant Spring (Hb CoSp) is described. The 24-year-old man did not have clinical symptoms, and his hematological indices were normal. However, he had a persistent slight elevation of fetal hemoglobin level. His mother and his brother were heterozygous for Hb D Punjab; his father had Hb CoSp trait. A sister did not have any abnormal hemoglobin. To show the exact molecular defect leading to the synthesis of Hb CoSp in this family, genomic DNA from the father was analyzed by hybridization with synthetic oligonucleotides. Genomic DNA was digested with Sst I and Hind III producing a 1.05-kb fragment from the 3' end segment of the alpha 2-globin gene, including the termination codon. Two nonadecamers were synthesized to serve as probes: one, entirely homologous to the normal 3' end of alpha 2A-globin gene sequence, including the termination codon TAA, the other different from it by a replacement of the T in the termination codon TAA with C, changing it to CAA, the codon for the amino acid glutamine. DNA from normal controls gave a positive signal with the normal alpha 2TAA oligonucleotide probe but negative with the alpha 2 CAA probe. The father of propositus who had Hb CoSp trait gave a positive signal with the normal alpha 2TAA oligonucleotide probe as well as with the alpha 2CAA oligonucleotide probe, showing him to be heterozygous for the alpha 2CAA-globin gene. This result shows that the Hb CoSp in the Batak family is indeed due to a replacement of T by C in the TAA termination codon of the alpha 2-globin gene changing it to CAA the condon for glutamine. This explains the resulting readthrough of the untranslated sequence of the mRNA. 相似文献
32.
CAILU LIUSHUZHENG 《Biomedical and environmental sciences : BES》1992,5(1):46-52
Human lymphocytes pre-exposed to 10 mGy or 50mGy of X-rays become less sensitive to subsequent large dose irradiation,exhibited lower rate of chromosome aberration than expected.This adaptive response could be inhibited by cycloheximide,a protein synthesis inhibitor for successive 2h period ranging from 0.5h before to 4h after the low dose exposure,indicating that the adaptive response was directly related with the protein synthesis. 相似文献
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34.
B超和彩色多普勒超声对原发性甲状旁腺功能亢进的诊断价值 总被引:11,自引:0,他引:11
报道应用B型超声及彩色多普勒超声对76例原发性甲状旁腺功能亢进症进行系统研究的结果。总的诊断效率:敏感性72%,特异性92%,正确率87%,阳性预测值69%,阴性预测值92%,以正常位置腺瘤的诊断效率最高,B型超声及彩色多普勒超声的诊断效率进行比较,敏感性有显著差异(P<0.05),正确率有非常显著差异(P<0.01),说明彩色多普勒超声的诊断正确率较高。本文还讨论了B型超声对甲状旁腺病变的定位价值、各类甲状旁腺病变的鉴别;同时对异位甲状旁腺病变、原发性甲旁亢危象、各种影像诊断的比较等也进行了讨论。 相似文献
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37.
目的 探讨西藏地区农、牧民生活习俗与包囊虫病的关系。方法 自制问卷对 7个县 2 40个家庭 163 1名成员与包囊虫感染有关的生活习俗进行调查分析。结果 饭前便后洗手的人仅有 16 1%,餐具一般都用天然水洗 ,大部家庭用天然绵羊绒擦洗茶具。大多数人都喝过河溪水 ,池塘水 ,人人都吃半生不熟的肉 ,半数以上的吃生肉和生血肠 ,绝大多数人喝未经消毒的鲜牛、羊奶。 10 0 %家庭养狗 ,所有人员与狗、羊、牛、马接触密切。包囊虫病人占调查人数 0 43 %( 7/ 163 1) ,有典型症状者占 0 67%( 11/ 163 1)。结论 当地居民感染包囊虫与不良生活习俗有关 相似文献
38.
以氯铂酸钾为原料,经硫酸氨铂(Ⅱ)中间体制得抗肿瘤药物顺糖氨铂(Ⅱ),操作简便,总收率46.1%。 相似文献
39.
现将本院2006年1月-2006年12月54例经DSA全脑造影及栓塞术的麻醉处理总结如下。
1资料与方法
1.1一般资料
本组54例患者中,男29例,女25例,年龄11-70岁,ASAⅡ-Ⅲ级,急诊11例。术前昏迷5例,术中动脉瘤破裂2例。 相似文献
40.
Summary In order to study the immune function of patients on maintenance hemodialysis (MHD), we assayed NK cell cytotoxicity against
K562 targets in 40 patients on MHD, and the production of IL-2 and IFN in peripheral blood mononuclear cells (PBMC) after PHA
stimulation, in contrast to those in normal controls. The results showed that NK cell activity and IL-2 and IFN levels were
markedly lower in the patients than in the controls. Afeter a single dialysis, NK cell activity as well as IL-2 and IFN levels
were elevated to different extent. But there was no significant change in patients after long-term dialysis. There was a positive
correlation between the NK cell activity and IL-2 and IFN activity in the controls, but no such correlation was found in the
patients on MHD. There was a positive correlation between the NK cell activity and IL-2 activity in patients after dialysis,
suggesting that immune function were impaired in the patients on MHD, with a decline in the activity of NK cell and IL-2 and
IFN, and a disorder of immune regulation cycle. These abnormal immune impairments in the patients could be partly corrected
by hemodialysis. However, long-term hemodialysis is not much helpful in the improvement of patient’s immune function. 相似文献