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941.
942.
X T Fu E Klohe C Alber W Y Yu G B Ferrara M P Pistillo M Ballas R W Karr 《Human immunology》1992,33(3):193-201
In a previous study, we used transfectants expressing hybrid HLA-DR(beta 1*0403)/DR(beta 1*0701) chains to map sequences involved in polymorphic antibody binding epitopes on DR(alpha, beta 1*0403) or DR(alpha, beta 1*0701) molecules. Amino acids 1-40 of the beta 1 domain were found to make the major contributions to most of the antibody binding epitopes studied. To begin to localize sequences that contribute to polymorphic antibody epitopes on DR(alpha,beta 1*0101), DR(alpha,beta 1*1101) and DR(alpha,beta 3*0202) molecules, we used indirect immunofluorescence and flow cytometry to assess the binding of mAb to transfectants expressing hybrid DR(beta 1*0101)/DR(beta 1*1101) or DR(beta 1*1101)/DR(beta 3*0202) chains that divide the DR beta chain into three segments: amino acids 1-40, 41-97, and the beta 2 domain. The results indicate that amino acids 41-97 of the beta 1 domain on DR(beta 1*0101), DR(beta 1*1101), or DR(beta 3*0202) are critical in most of the epitopes, including those recognized by human antibodies MP4 and MP12, and mouse mAb GS88.2, I-LR1, 21r5, and 7.3.19.1, whereas amino acids 1-40 of DR(beta 1*1101) are critical in the epitope recognized by the MCS-7 mAb, and both segments 1-40 and 41-97 of DR(beta 1*1101) are important in the epitopes recognized by the I-LR2 and UL-52 mAbs. Based on these data and comparison of DR beta allelic protein sequences, the residues that may play critical roles in these antibody binding epitopes are predicted. 相似文献
943.
944.
945.
Changes in HIV-1 incidence in heroin users in Guangxi Province, China 总被引:10,自引:0,他引:10
Lai S Liu W Chen J Yang J Li ZJ Li RJ Liang FX Liang SL Zhu QY Yu XF 《Journal of acquired immune deficiency syndromes (1999)》2001,26(4):365-370
Guangxi Province, China recently experienced an outbreak of HIV-1 infection among heroin users. We studied HIV-1 incidence rates and associated risk factors for HIV-1 infection among heroin users residing in Pingxiang City. A total of 318 heroin users were followed from February 1998 through January 1999 (median follow-up: 8.1 months). Of these, 130 were prospectively followed from January through September 1999 (median follow-up: 8.3 months). HIV-1 and hepatitis C virus (HCV) incidence rates for each period were calculated. A generalized estimating equation approach was implemented to identify independent risk factors associated with HIV-1 infection across both periods. Among 318 study participants, 97.2% were men. The median age was 22 years. Approximately 60% reported sharing needles. HIV-1 prevalence at baseline was 15.4%. During the first follow-up period, HIV-1 incidence was 2.38 per 100 person years (py), and HCV incidence was 26.8 per 100 py. During the second follow-up period, HIV-1 incidence was 6.86 per 100 py, and HCV incidence was 28.9 per 100 py. After controlling for age and other factors, HCV seropositivity, history of sexually transmitted diseases, and sharing needles were independently associated with HIV-1 infection. These data suggest that HIV-1 incidence was rising over time in Pingxiang City, Guangxi Province. The high incidence of HCV heightens the importance of enhanced prevention programs to reduce injection and needle sharing among heroin users. 相似文献
946.
I. A. Leneva P. V. Gulak Yu. N. Dubrov A. S. Sobolev 《Bulletin of experimental biology and medicine》1990,109(5):641-644
Department of Biomembranes, Research Center for Development and Introduction of Modern Methods of Molecular Diagnosis, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR I. P. Ashmarin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 5, pp. 483–485, May, 1990. 相似文献
947.
L. G. Krymskaya N. Yu. Gromykhina V. A. Kozlov 《Bulletin of experimental biology and medicine》1988,105(3):366-367
Laboratory of Regulation of Immunopoiesis, Institute of Clinical Immunology, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 105, No. 3, pp. 311–313, March, 1988. 相似文献
948.
V. V. Evdokimov V. I. Erasova V. I. Kirpatovskii V. M. Kodentsova O. A. Vrzhesinskaya N. A. Beketova L. F. Kurilo T. V. Ostroumova L. V. Shileiko I. Yu. Sakharov I. Yu. Nefedov 《Bulletin of experimental biology and medicine》1998,126(6):1221-1223
Reduction in the epididymis weight and in the spermatozoid concentration together with marked morphological changes in the
seminiferous tubules were observed in the progeny of irradiated rats. Vitamin E content in the testes increased 2.8-fold,
while that of vitamin B2 decreased 1.6-fold.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 652–654, December, 1998. 相似文献
949.
Nerve growth factor (first of three parts). 总被引:7,自引:0,他引:7
W C Mobley A C Server D N Ishii R J Riopelle E M Shooter 《The New England journal of medicine》1977,297(20):1096-1104
950.
F Z Yu K Sugano H Ohkura S Mori 《Rinsho byori. The Japanese journal of clinical pathology》1991,39(10):1087-1092
A sandwich radioimmunometric assay using monoclonal antibodies 6G10 and SV2-61 gamma directed to the extracellular domain of the c-erbB-2 oncogene product was developed and the antigen levels in sera from normal donors and patients with breast carcinoma were determined. The antigen levels in normal donors were uniformly low (9.52 +/- 0.91 ng/ml) and 3.0% (2/66 cases) slightly exceeded the cutoff value (11.4 ng/ml). In patients with breast carcinoma, serum c-erbB-2 protein levels increased and the positivity was as high as 45.7% (16/35 cases) in recurrent cases. Determination of c-erbB-2 protein may be a useful marker for serological diagnosis of breast carcinoma. 相似文献