全文获取类型
收费全文 | 426605篇 |
免费 | 24746篇 |
国内免费 | 16608篇 |
专业分类
耳鼻咽喉 | 3388篇 |
儿科学 | 9561篇 |
妇产科学 | 5598篇 |
基础医学 | 49532篇 |
口腔科学 | 5845篇 |
临床医学 | 43948篇 |
内科学 | 65588篇 |
皮肤病学 | 3284篇 |
神经病学 | 28614篇 |
特种医学 | 18090篇 |
外国民族医学 | 119篇 |
外科学 | 53858篇 |
综合类 | 45830篇 |
现状与发展 | 55篇 |
一般理论 | 16篇 |
预防医学 | 35825篇 |
眼科学 | 9359篇 |
药学 | 37664篇 |
217篇 | |
中国医学 | 15367篇 |
肿瘤学 | 36201篇 |
出版年
2024年 | 969篇 |
2023年 | 3888篇 |
2022年 | 10092篇 |
2021年 | 12759篇 |
2020年 | 9619篇 |
2019年 | 8191篇 |
2018年 | 29884篇 |
2017年 | 24903篇 |
2016年 | 26561篇 |
2015年 | 12391篇 |
2014年 | 15112篇 |
2013年 | 14148篇 |
2012年 | 26132篇 |
2011年 | 41292篇 |
2010年 | 32744篇 |
2009年 | 22720篇 |
2008年 | 32943篇 |
2007年 | 35090篇 |
2006年 | 13398篇 |
2005年 | 14242篇 |
2004年 | 11953篇 |
2003年 | 12609篇 |
2002年 | 9490篇 |
2001年 | 6097篇 |
2000年 | 5881篇 |
1999年 | 5291篇 |
1998年 | 3478篇 |
1997年 | 3488篇 |
1996年 | 2501篇 |
1995年 | 2384篇 |
1994年 | 2129篇 |
1993年 | 1437篇 |
1992年 | 1751篇 |
1991年 | 1667篇 |
1990年 | 1451篇 |
1989年 | 1232篇 |
1988年 | 1095篇 |
1987年 | 962篇 |
1986年 | 804篇 |
1985年 | 638篇 |
1984年 | 507篇 |
1983年 | 410篇 |
1982年 | 361篇 |
1981年 | 286篇 |
1980年 | 272篇 |
1979年 | 257篇 |
1978年 | 217篇 |
1977年 | 228篇 |
1976年 | 209篇 |
1974年 | 179篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
Marlene L Hauck Susan M LaRue William P Petros Jean M Poulson Daohai Yu Ivan Spasojevic Amy F Pruitt Allison Klein Beth Case Donald E Thrall David Needham Mark W Dewhirst 《Clinical cancer research》2006,12(13):4004-4010
PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a low temperature sensitive liposome (LTSL) when given concurrently with local hyperthermia to canine solid tumors. EXPERIMENTAL DESIGN: Privately owned dogs with solid tumors (carcinomas or sarcomas) were treated. The tumors did not involve bone and were located at sites amenable to local hyperthermia. LTSL-doxorubicin was given (0.7-1.0 mg/kg i.v.) over 30 minutes during local tumor hyperthermia in a standard phase I dose escalation study. Three treatments, given 3 weeks apart, were scheduled. Toxicity was monitored for an additional month. Pharmacokinetics were evaluated during the first treatment cycle. RESULTS: Twenty-one patients were enrolled: 18 with sarcomas and 3 with carcinomas. Grade 4 neutropenia and acute death secondary to liver failure, possibly drug related, were the dose-limiting toxicities. The maximum tolerated dose was 0.93 mg/kg. Other toxicities, with the possible exception of renal damage, were consistent with those observed following free doxorubicin administration. Of the 20 dogs that received > or = 2 doses of LTSL-doxorubicin, 12 had stable disease, and 6 had a partial response to treatment. Pharmacokinetic variables were more similar to those of free doxorubicin than the marketed liposomal product. Tumor drug concentrations at a dose of 1.0 mg/kg averaged 9.12 +/- 6.17 ng/mg tissue. CONCLUSION: LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors. It was well tolerated and resulted in favorable response profiles in these patients. Additional evaluation in human patients is warranted. 相似文献
12.
高压氧综合治疗持续植物状态30例疗效分析 总被引:14,自引:0,他引:14
目的评估高压氧综合治疗持续植物状态的疗效和探讨最佳治疗方案。方法回顾性分析了1999年—2005年应用高压氧治疗的30例持续植物状态病例,主要分析了原发病因、高压氧治疗次数以及高压氧治疗时机与疗效的关系。结果脑外伤组显效率和好转率明显高于非脑外伤组(P<0.05),开始治疗时间≤30d组及31~60d组好转率明显高于≥61d组(P<0.05)。结论高压氧综合治疗对脑外伤所致持续植物状态患者60d以内开始行高压氧治疗的患者疗效较好。 相似文献
13.
14.
15.
16.
17.
The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing 总被引:1,自引:0,他引:1
Kevin Conway MRCS ; Patricia Price PhD ; Keith G. Harding FRCS ; Wen G. Jiang MD 《Wound repair and regeneration》2006,14(1):2-10
Wound healing involves a number of cellular and molecular events, many of which are controlled by soluble growth factors. In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles during several stages of this complex biological process. Produced primarily by stromal fibroblasts, hepatocyte growth factor regulates angiogenesis, vascular permeability, cell migration, matrix deposition and degradation, and other biological processes. The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair. 相似文献
18.
培养护生养成阅读药物说明书的习惯 总被引:2,自引:0,他引:2
同类药物因原料来源、附加成分和生产厂家不同而商品名称各异,有些名称相似的药物其性能却完全不同。临床实习护生常反映课本讲授的药物知识与临床用药相差甚远,不知如何记住所有的药物。为此,作者在临床教学中培养学生养成阅读药物说明书的习惯,收到良好效果。 相似文献
19.
20.
A new semi-empirical formula for the evaluation of (n,(3)He) reaction cross-sections at the energy of 14.6 and 20 MeV is presented. Formula was derived using the analytical expression for the evaluation of the (3)He spectrum within the frame of pre-equilibrium exciton model. The systematics obtained is compared with the empirical formula for the (n,(3)He) reaction cross-section. 相似文献