Attempting to distinguish between endogenous and contaminating cytokeratins in a corneal proteomic study

Background  

The observation of cytokeratins (CK's) in mass spectrometry based studies raises the question of whether the identified CK is a true endogenous protein from the sample or simply represents a contaminant. This issue is especially important in proteomic studies of the corneal epithelium where several CK's have previously been reported to mark the stages of differentiation from corneal epithelial stem cell to the differentiated cell.     

Ocular fat embolism syndrome

Ocular fat embolism syndrome in the complete absence of any cardiac defects is a rare phenomenon which is not commonly encountered in ophthalmic practice. We present a case of a 16-year-old girl with fat embolism syndrome and involvement of the retina after a tibial fracture without any cardiac defect.     

Surgical results of heavy silicone oil HWS-45 3000 as internal tamponade for inferior retinal detachment with PVR: a pilot study

Purpose  

To report the results of a prospective pilot study using a new heavy agent, HWS-45 3000, as endotamponade in complicated inferior retinal detachment.     

Chemical impurities and contaminants in different silicone oils in human eyes before and after prolonged use

Background  

Intraocular silicone oil (SiO) impurities as low molecular weight components (LMWC) and residual catalysts are thought to cause ocular toxicity. A case-control study was initiated to determine if highly purified SiOs of equal viscosity from two different manufacturers had a similar chemical stability after prolonged clinical use as a vitreous substitute in patients.     

A disposable system for rapid purification of autologous plasmin as an adjunct to vitrectomy — performance and safety profile

Background  

The generation of an atraumatic posterior vitreous detachment (PVD), a common goal in vitreoretinal surgery, is a challenge particularly in children and young trauma patients. Plasmin has been proposed as a surgical adjunct to enzymatically generate a PVD. This study assesses the performance and safety of a new system for rapid purification of plasmin as an adjunct to vitrectomy.     

Effect of menthol on ocular drug delivery

Background  

To assess how safe and effective it is to use menthol as a permeability enhancer in ophthalmic drug delivery systems.     

Ophthalmopathology in rats with MBP-induced experimental autoimmune encephalomyelitis

Purpose  

Multiple studies indicate that T-cells play a major role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, but recently an involvement of antibodies has also been discussed. The aim of our study was to examine the effects of myelin basic protein (MBP) immunization on survival of neurons, alteration of antibody reactivity, and microglia in the retinal ganglion cell layer.