全文获取类型
收费全文 | 184637篇 |
免费 | 34116篇 |
国内免费 | 2582篇 |
专业分类
耳鼻咽喉 | 5572篇 |
儿科学 | 5998篇 |
妇产科学 | 2713篇 |
基础医学 | 7616篇 |
口腔科学 | 2501篇 |
临床医学 | 29048篇 |
内科学 | 55872篇 |
皮肤病学 | 8074篇 |
神经病学 | 17470篇 |
特种医学 | 7678篇 |
外科学 | 46591篇 |
综合类 | 464篇 |
现状与发展 | 72篇 |
预防医学 | 8161篇 |
眼科学 | 3982篇 |
药学 | 3961篇 |
中国医学 | 100篇 |
肿瘤学 | 15462篇 |
出版年
2024年 | 700篇 |
2023年 | 4944篇 |
2022年 | 1544篇 |
2021年 | 3686篇 |
2020年 | 6293篇 |
2019年 | 2576篇 |
2018年 | 7926篇 |
2017年 | 7761篇 |
2016年 | 8959篇 |
2015年 | 9012篇 |
2014年 | 16217篇 |
2013年 | 16571篇 |
2012年 | 6936篇 |
2011年 | 7135篇 |
2010年 | 11282篇 |
2009年 | 15020篇 |
2008年 | 7205篇 |
2007年 | 5516篇 |
2006年 | 8017篇 |
2005年 | 5443篇 |
2004年 | 4608篇 |
2003年 | 3574篇 |
2002年 | 3733篇 |
2001年 | 5037篇 |
2000年 | 4396篇 |
1999年 | 4437篇 |
1998年 | 4118篇 |
1997年 | 3835篇 |
1996年 | 3734篇 |
1995年 | 3516篇 |
1994年 | 2250篇 |
1993年 | 1863篇 |
1992年 | 2204篇 |
1991年 | 2153篇 |
1990年 | 1796篇 |
1989年 | 1966篇 |
1988年 | 1728篇 |
1987年 | 1502篇 |
1986年 | 1498篇 |
1985年 | 1291篇 |
1984年 | 1007篇 |
1983年 | 859篇 |
1982年 | 712篇 |
1981年 | 561篇 |
1980年 | 537篇 |
1979年 | 600篇 |
1978年 | 567篇 |
1977年 | 579篇 |
1975年 | 417篇 |
1972年 | 447篇 |
排序方式: 共有10000条查询结果,搜索用时 796 毫秒
991.
992.
Shuji Kurane MD Marjorie T. Arca MD Atsushi Aruga MD PhD Robert A. Krinock BS John C. Krauss MD Dr. Alfred E. Chang MD 《Annals of surgical oncology》1997,4(7):579-585
Background: We examined alternative methods of delivering cytokines as an adjunct for priming lymph node (LN) cells draining sites of vaccine inoculation for the purpose of generating immune cells for adoptive immunotherapy.
Methods: Using syngeneic murine tumors we examined the ability of IL-2, IL-4, or GM-CSF delivered locally to a site of tumor inoculum to induce antitumor reactive draining LN cells. Mice were inoculated subcutaneously with tumor cells transduced to secrete cytokine; tumor cells admixed with fibroblasts transduced to secrete cytokine; or intralesional inoculation of cytokine in established tumor to induce sensitized LN cells capable of mediating tumor regression in adoptive transfer.
Results: Both IL-4 and GM-CSF cytokines were effective in enhancing the antitumor reactivity of vaccine-primed LN cells compared to IL-2, which was ineffective. The local delivery of GM-CSF by autocrine or paracrine secretion of genetically engineered cells, as well as direct intratumoral delivery was capable of upregulating LN sensitization compared to systemic administration, which did not.
Conclusions: The local delivery of GM-CSF as an adjuvant for tumor vaccination can be accomplished by various methods, including direct injection, which avoids the need for gene transfer. 相似文献
993.
Sidestream versus mainstream carbon dioxide analyzers 总被引:1,自引:0,他引:1
994.
995.
J. Gong B. D. Rawal C. F. Högman MD G. N. Vyas B. Nilsson and I. Gustafsson 《Vox sanguinis》1994,66(3):166-170
We report studies on the complement sensitivity of four strains of Yersinia enterocolitica , serotypes O:3, O:9, O:5,27, and O:20, isolated from blood units involved in transfusion fatalities. Complement in fresh CPD plasma killed Y. enterocolitica within 4 h at 22°C in 100% of the experiments. The bactericidal action was serotype and complement activation pathway dependent. Both classic and alternate pathways seemed to be active, but the latter to a lesser degree. When the classic pathway was blocked by chelation of Ca2+ no complete killing was obtained. Complement did not enhance or condition Yersinia for leucocyte filter retention. Direct removal of Yersinia by filtration was also related to serotype; all strains were reduced by filtration in heat-inactivated plasma, and all except serotype O:5,27 were reduced in Ca2+ -chelated plasma. Our findings may explain why plasma products and platelet concentrates are rarely involved in Yersinia sepsis related to transfusion. 相似文献
996.
997.
Y Watanabe H Kanayama K Kato T Kanbe H Matsui S Mitani M Yoshino Y Nishiyama M Kanzaki 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(10):1311-1316
A 56-year-old man was admitted to our hospital with right chest pain. Chest X-ray, CT scan and MRI revealed a chest wall tumor and enlarged mediastinal lymph nodes. Percutaneous lung biopsy was performed, and the pathological diagnosis of pleomorphic rhabdomyosarcoma was obtained. The only significant abnormal laboratory finding was elevation of serum NSE (24.5 ng/ml). Although chemotherapy (VAC-ADM) and radiation therapy were performed, the patient died about 7 months after admission. To our knowledge, only 17 cases of chest wall rhabdomyosarcoma have been reported in Japan. 相似文献
998.
James F. Meschia MD Robert M. Pascuzzi MD José Biller MD 《Journal of stroke and cerebrovascular diseases》1997,6(6):434-435
Limited randomized clinical trial data favor the use of anticoagulation in patients with cerebral venous thrombosis. We present a patient with deep cerebral venous thrombosis in whom anticoagulation was withheld because of coexistent intraventricular hemorrhage. She had a benign clinical course without anticoagulation, suggesting that close observation may be a management option in these patients. 相似文献
999.
1000.