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1.
外固定架在前臂严重粉碎及多段骨折中的应用 总被引:1,自引:0,他引:1
目的:探讨应用单侧多功能外固定支架治疗前臂骨干严重粉碎性及多段骨折的临床疗效。方法:回顾性分析本院1993至2002年间收治的前臂骨干严重粉碎性及多段骨折患共22例。其中开放性骨折5例,均急诊清创复位外固定架固定;闭合性骨折17例,以切开复位单侧多功能外固定架固定结合简单内固定为主要治疗方法。运用Anderson标准进行前臂功能评价。结果:22例患中发生1例骨延迟愈合,1例骨不愈合,均经二次手术植骨后得到愈合。按Anderson标准评价,优7例,良10例,不满意3例,失败2例,优良率78%。结论:单侧多功能外固定支架在前臂尺桡骨骨干严重粉碎性及多段骨折的治疗中有独特的优势,闭合复位外固定架固定或切开复位外固定架固定结合运用简单的内固定可发挥内外固定各自长处,在取得良好固定作用的同时,减少骨折端血运的破坏,达到生物学固定的要求. 相似文献
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目的探讨晚期非小细胞肺癌患者血中T细胞亚群、CD4+CD25+调解性T细胞(Treg)及免疫球蛋白的改变,观察康莱特注射液(KLT)联合化疗对晚期非小细胞肺癌患者免疫功能的影响。方法将68例晚期非小细胞肺癌患者随机分为2组,对照组应用多西他赛、顺铂联合化疗,不予康莱特及其他提高免疫力的治疗措施;治疗组同时给予康莱特注射液200 m L静点,连用14 d。2组均以21 d为1个周期,2个周期后评价T细胞亚群及免疫球蛋白的变化情况。另选30例健康人作为正常对照组。结果化疗前对照组及治疗组患者T细胞亚群CD3+、CD4+、CD8+比例及CD4+CD25+Treg与正常对照组比较差异有统计学意义(P均0.05)。化疗后对照组免疫球蛋白、CD3+、CD4+、CD8+、CD4+/CD8+比值及治疗组CD4+CD25+Treg与化疗前比较差异有统计学意义(P均0.05)。化疗后对照组与治疗组CD3+、CD4+、CD8+及CD4+/CD8+比值、Ig G比较差异有统计学意义(P均0.05)。结论康莱特注射液可保护晚期非小细胞肺癌患者的免疫功能,降低免疫耐受。 相似文献
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Li Yingxian Chen Wei Zhao Linchun Zhang Ji-Quan Zhao Yonglong Li Chun Guo Bing Tang Lei Yang Yuan-Yong 《RSC advances》2022,12(32):20550
Amide is a fundamental group that is present in molecular structures of all domains of organic chemistry and the construction of this motif with high atom economy is the focus of the current research. Specifically, N-methyl amides are valuable building blocks in natural products and pharmaceutical science. Due to the volatile nature of methyl amine, the generation of N-methyl amides using simple acids with high atom economy is rare. Herein, we disclose an atom economic protocol to prepare this valuable motif under DABCO/Fe3O4 cooperative catalysis. This protocol is operationally simple and compatible with a range of aliphatic and (hetero)aromatic acids with very good yields (60–99%). Moreover, the Fe3O4 can be easily recovered and high efficiency is maintained for up to ten cycles.The generation of N-methyl amides using simple acids with high atom economy is rare owning to the volatile nature of methyl amine. Herein, an atom economic protocol was disclosed to prepare this valuable motif under DABCO/Fe3O4 cooperative catalysis.Amide is a fundamental group that is present in molecular structures of all domains of organic chemistry.1 It is widely distributed in natural products, synthetic drugs and functional polymers, and is also the key chemical connection in proteins.2 It has been shown that amide bond formation alone accounts for 65% of all preliminary screening reactions in the pharmaceutical industry.3 This means the generation of amide bonds with high atom efficiency is of high practical importance. And not surprisingly, ‘amide formation avoiding poor atom economy reagents’ was voted as the top challenge for organic chemistry by the ACS Green Chemistry Institute in 2007.3From synthetic point of view, the ideal way to produce amide bonds would be the direct coupling of readily available carboxylic acids and amines, but this process is thermodynamically unfavourable due to the formation of the corresponding carboxylate-ammonium salt,4 therefore, stoichiometric amount of coupling reagents, such as DCC, DIC, EDCI, HATU, HBTU, HCTU, SOCl2, BOP, acid chloride etc, are generally required to sidestep thermal conditions for amide bond formation.5 These reagents are highly successful, but the process generally suffers from poor atom economy and side products removal issue especially in the large-scale applications.5 To overcome these drawbacks, “nonclassical” amide bonds formation routes were investigated.6 In these processes, the catalyst takes the role of a coupling reagent in generating an active ester suitable for amidation in a waste-free manner. However, these processes have not been applied in the preparation of N-methyl amides, probably because the methyl amine was delivered in its hydrochloride salt, alcoholic or aqueous form due to its volatile nature.On a different note, N-methyl amides are extensively presented in numerous natural products and pharmaceutical molecules, as shown in Fig. 1,7 and the methylation of amides is a promising way to improve the pharmacological property of molecules.8 However, the synthesis of N-methyl amides compounds relies heavily on non-catalytic approaches.5,9 Catalytic approaches were also investigated by Hisaeda,10 Kundu,11 Li,12 Guo,13 Yu,14 Maruoka,15 Wang,16 Chen,17 Lamaty18 and their co-workers starting from nitriles, primiary amides, aldoximes, aldehydes, lignin, carbamoylsilane and alcohols. Until recently, Thakur,19 Marce,20 Sadeghzadeh21 and their co-workers developed elegant N-methyl amidation approach starting from carboxylic acids under nano-MgO, diatomite Earth@IL/ZrCl4 and Mg(NO3)2·6H2O catalysis respectively, while limitations like poor substrate scope or sophisticated tailored catalyst still persist. Mindful of all the above issues, developing an N-methyl amidation process of simple carboxylic acids, which is still of great challenge in synthesis, and establishing a broad (hetero)aryl scope with high atom economy from commercial available reagents and catalysts were critical considerations in this study. Moreover, the significance of N-methyl amides combined with our interests in the development of green synthetic approaches motivated us to explore the direct coupling of the carboxylic acids and isothiocyanates. To the best of our knowledge, this is the first successful work using isothiocyanatomethane to prepare N-methyl amides.Open in a separate windowFig. 1Marketed drugs bearing N-methyl amide group.Our initial investigation begins with phenylacetic acid and isothiocyanatomethane as model substrate for condition optimization. Using acetonitrile as solvent, only trace amount of product was detected under catalyst free or p-toluenesulfonic acid (PTSA) catalysis conditions ( Entry Additive Time (h) Catalyst Yield (%) 1 — 24 — 5 2 — 24 PTSA — 3 — 48 TEA 17 4 — 48 DBU 45 5 — 48 DMAP 43 6 — 48 DBN 51 7 — 48 DABCO 65 8 LiBr 48 DABCO 71 9 Mn(OAc)2 48 DABCO 75 10 MnO 48 DABCO 79 11 MgO 48 DABCO 88 12 Al2O3 48 DABCO 85 13 Fe3O4 48 DABCO 98 14 Fe3O4 24 DABCO 75 15b Fe3O4 48 DABCO 80