冠心病心绞痛患者行丹参多酚酸盐治疗的效果

目的分析冠心病心绞痛患者采取丹参多酚酸盐治疗效果及安全影响。方法选取本院2017年7月-2018年6月接收的冠心病心绞痛患者72例为研究对象,随机分为两组,各36例,对照组行丹参注射液治疗方案,研究组则接受丹参多酚酸盐治疗方案,对比两组临床疗效及不良反应发生率。结果在治疗总有效率方面,对照组是72.22%,研究组是94.44%,研究组较对照组更高,差异有统计学意义(P<0.05);在不良反应发生率方面,对照组与研究组分别是8.33%和5.56%,研究组与对照组差异统计学无意义(P>0.05);研究组心绞痛发作次数较对照组更低,差异存在统计学意义(P<0.05);而运动诱发ST段压低1 mm时间、运动诱发心绞痛发作时间及总运动代谢量,对照组与研究组差异统计学无意义(P>0.05)。结论冠心病心绞痛疾病治疗期间,应用丹参多酚酸盐治疗方案,不仅可以减少冠心病心绞痛发作次数,同时有助于改善患者临床症状,促进治疗效果的提高,此外,具有较高的安全性。     

彩色多普勒超声对肝圆韧带架桥门-腔静脉分流术后桥血管通畅性的评价

目的探讨彩色多普勒超声对肝圆韧带架桥门-腔静脉分流术后桥血管通畅性的观察,进而对手术疗效进行评价。方法肝圆韧带架桥门-腔静脉分流术后病人共43例,用二维超声及彩色多普勒分别于术后3、12及24个月观察桥血管通畅情况,依据桥血管不同的超声表现,分为桥血管通畅组和桥血管狭窄组两组。结果术后3个月,有41例血管通畅,2例血管狭窄;术后12个月38例血管通畅,5例血管狭窄;术后24个月30例血管通畅,13例血管狭窄,随着时间的延长桥血管发生狭窄的概率增加,术后3个月与24个月比较,P <0. 05。结论术后彩色多普勒超声监测桥血管是评价手术效果的重要手段。     

A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population

Amnestic mild cognitive impairment (MCI) might be more likely to progress to Alzheimer’s disease than single non-memory MCI and multiple domain MCI. After excluding those who did not conform to the inclusion criteria of amnestic MCI or healthy controls, a neuropsychologic battery that included the Mini-Mental State Examination, Clinical Dementia Rating, Chinese version of the Montreal Cognitive Assessment, Instrumental Activities of Daily Living scale and Auditory Verbal Learning Test was performed on 150 amnestic MCI and 150 normal control patients. The Chinese version of the Montreal Cognitive Assessment was measured for its test-retest reliability, sensitivity and specificity. Blood was collected for apolipoprotein E (APOE) genotyping. Compared with the control group, the amnestic MCI group performed significantly worse on all neuropsychological tests, and non-APOE-??4 carriers in the amnestic MCI group performed better than APOE-??4 carriers in the amnestic MCI group. The set of neuropsychological tests in our study could distinguish amnestic MCI participants from normal elderly participants accurately. APOE did have a role in amnestic MCI patients, but the magnitude and mechanism of its influence are not fully understood.     

医德养成教育和医学理性精神对医德建设的启示

系统性和实践性的医德养成教育应该使从医人员和医学生清醒而明确地认识和把握医德对人类社会健康生活产生的社会作用、医德的基本要求、医学目的内涵和始终坚持慎独,加强医德修养,树立医学理性精神等问题.明晰医学理性精神的基本要素、惰性因素和医学应当与医学理性精神的统一性是一个现实命题.     

基于VR技术的人体科学馆虚拟场景模型构建

以虚拟现实技术为基础,以新乡医学院人体科学馆为研究对象,分析、设计、构建了人体科学馆虚拟场景三维模型,并通过实例为读者提供实现虚拟场景构建的思路与方法.同时,分析了三维模型的优劣对虚拟场景交互系统的影响.     

以痛为输火针点刺治疗枕神经痛随机对照研究

目的 比较以痛为输火针点刺与卡马西平（以下简称对照组）治疗枕神经痛的疗效差异及安全性.方法 将枕神经痛患者以抽签法随机分为火针组和对照组,火针组30例以痛为输选取阿是穴行火针点刺治疗,对照组27例予口服卡马西平,于治疗前和治疗1疗程后采用视觉模拟评分（VAS）进行疗效评定.结果 两组VAS治疗后较治疗前均明显降低（P＜0.01）,治疗后火针组VAS较对照组更为减低,组间比较差异有统计学意义（P＜0.01）;治疗后火针组显愈率为90.0％,对照组分为51.8％,组间比较差异具有统计学意义（P＜0.01）.结论 以痛为输火针点刺治疗枕神经痛止痛效果更好,且安全性好,具有更好的的疗效.     

海水浸泡与低温对腹部开放伤大鼠血清VEGF含量的影响

目的研究海水浸泡与低温对腹部开放伤大鼠血清中血管内皮生长因子（VEGF）含量的影响。方法将sD大鼠随机分为腹部开放伤合并常温生理盐水浸泡组（对照组）、腹部开放伤合并低温生理盐水浸泡组（低温组）、腹部开放伤合并常温海水浸泡组（常温海水组）和腹部开放伤合并低温海水浸泡组（低温海水组）,各组浸泡1h后,分别检测实验大鼠血清中VEGF含量。结果海水浸泡、低温及其两者的交互作用对大鼠血清VEGF含量的影响均有统计学意义（P〈0．05或P〈0．01）。结论海水浸泡可引起大鼠血清VEGF含量升高,低温不能独立促使血清VEGF含量升高,但是可以加重海水浸泡引起的血清VEGF含量升高。     

Emodin from Aloe Inhibits Porcine Reproductive and Respiratory Syndrome Virus via Toll-Like Receptor 3 Activation

Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe reproductive failure in sows and respiratory diseases in growing and finishing pigs and results in great economic losses to the swine industry. Although vaccines are available, PRRSV remains a major threat to the pig farms. Thus, there is an urgent need to develop antiviral drugs to compensate for vaccines. In this study, we report that Aloe extract (Ae) can strongly inhibit PRRSV in Marc-145 cells and porcine alveolar macrophages lines (iPAMs) in vitro. Furthermore, we identified a novel anti-PRRSV molecule, Emodin, from Ae by high-performance liquid chromatography (HPLC). Emodin exerted its inhibitory effect through targeting the whole stages of PRRSV infectious cycle. Moreover, we also found that Emodin can inactivate PRRSV particles directly. Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-α (p < 0.05) and IFN-β expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect. These findings imply that the Emodin from Aloe could hamper the proliferation of PRRSV in vitro and might constitute a new approach for treating PRRSV infection.     

重组人白细胞介素11对正常及骨髓抑制小鼠的促血小板生？…

本试验的目的是观察国产重组人白细胞介素１１（ｒｈＩＬ－１１）皮下注射对正常小鼠和骨髓抑制小鼠的血液学效应。给正常小鼠ｒｈＩＬ－１１ ２００及４００μｇ／ｋｇ皮下注射,连续７天,第５天时外周血血小板数轻度升高,起效较平缓,停药后血小板数可在４天内恢复到给药前水平。对骨髓抑制小鼠,ｒｈＩＬ－１１的治疗可明显地减轻外周血小板计数的下降程度,促进血小板计数的恢复。ｒｈＩＬ－１１在每天１００－１００μｇ／ｋ     

The effect of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus

International Journal of Diabetes in Developing Countries - The objective is to investigate the effects of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus. Thirty-two...