全文获取类型
收费全文 | 8821篇 |
免费 | 508篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 182篇 |
妇产科学 | 88篇 |
基础医学 | 1115篇 |
口腔科学 | 227篇 |
临床医学 | 553篇 |
内科学 | 2180篇 |
皮肤病学 | 232篇 |
神经病学 | 613篇 |
特种医学 | 675篇 |
外科学 | 1412篇 |
综合类 | 66篇 |
预防医学 | 298篇 |
眼科学 | 350篇 |
药学 | 501篇 |
中国医学 | 27篇 |
肿瘤学 | 764篇 |
出版年
2023年 | 47篇 |
2022年 | 99篇 |
2021年 | 149篇 |
2020年 | 96篇 |
2019年 | 122篇 |
2018年 | 167篇 |
2017年 | 129篇 |
2016年 | 177篇 |
2015年 | 191篇 |
2014年 | 219篇 |
2013年 | 275篇 |
2012年 | 359篇 |
2011年 | 391篇 |
2010年 | 275篇 |
2009年 | 224篇 |
2008年 | 391篇 |
2007年 | 426篇 |
2006年 | 421篇 |
2005年 | 472篇 |
2004年 | 389篇 |
2003年 | 413篇 |
2002年 | 442篇 |
2001年 | 343篇 |
2000年 | 325篇 |
1999年 | 276篇 |
1998年 | 118篇 |
1997年 | 94篇 |
1996年 | 64篇 |
1995年 | 61篇 |
1994年 | 69篇 |
1993年 | 53篇 |
1992年 | 203篇 |
1991年 | 169篇 |
1990年 | 155篇 |
1989年 | 161篇 |
1988年 | 136篇 |
1987年 | 153篇 |
1986年 | 143篇 |
1985年 | 152篇 |
1984年 | 102篇 |
1983年 | 78篇 |
1982年 | 46篇 |
1979年 | 66篇 |
1978年 | 44篇 |
1977年 | 36篇 |
1976年 | 38篇 |
1975年 | 44篇 |
1971年 | 38篇 |
1970年 | 38篇 |
1969年 | 40篇 |
排序方式: 共有9367条查询结果,搜索用时 15 毫秒
31.
32.
A transparent polyvinyl alcohol (PVA) hydrogel was prepared from a PVA solution in a mixed solvent consisting of water and a water miscible organic solvent by cooling. The physical properties were evaluated in comparison with commercially available soft contact lens materials, such as polyhydroxyethyl methacrylate (PHEMA) and copolymers of methyl methacrylate (MMA) and N-vinyl pyrrolidone (VP). The PVA hydrogel showed higher tensile strength and elongation at break than the other materials, while it had high water content and oxygen permeability the latter being comparable to those of PMMA/VP copolymers. The protein adsorption of the PVA hydrogel was much less than those of the other materials. The PVA hydrogel soft contact lenses were applied on rabbit eyes for 12 weeks. The influence on the cornea was studied by biomicroscopy, ultrasonic corneal pachymetry and histopathological examination. These examinations revealed no abnormal findings in the cornea. These results suggest that the PVA hydrogel may be promising as a new soft contact lens material. 相似文献
33.
OBJECTIVE: We aimed to determine whether or not the potential distribution of the sympathetic skin response (SSR) on the palm and dorsum of the hand can be described by an equivalent current dipole (ECD) as an SSR source model. METHODS: The SSR of 22 normal subjects were simultaneously obtained from two electrodes placed on the palm and the dorsum of hand, with an indifferent electrode on the thumbnail. We then measured the SSR potential distribution in 10 of the 20 subjects who had responded to stimulation with a clear dorsal SSR. To do this, 18 electrodes were attached to the palm and dorsum of the hand. SSR-evoking stimulation (sound, voice and rapid inspiration) were randomly delivered to the subject at time intervals of more than 1min to minimize the habituation effect. We estimated the ECD from the measured potential distribution. RESULTS AND CONCLUSIONS: The SSR-evoked by stimulation was negative in potential at the palmar sites of all 22 subjects, and was positive in potential at the dorsal sites of the hand in 20 of the 22 subjects. The SSR potential distribution, which was measured in 10 subjects, reached its maximum negative and positive potential near the base of the middle finger on the palm, and near the corresponding site on the dorsum of the hand, respectively. The SSR potential measured on the dorsum of the hand, however, was about 1/3 in amplitude of those on the palmar sites. These results suggest that the SSR source is located on the palm (probably the sweat glands) as confirmed by the estimated ECD (a negative pole on the palm and a positive pole on the dorsum of the hand). We speculate that the SSR may result from the potential difference caused by the Na(+) concentration gradient in the sweat, which results from intracanal reabsorption of Na(+). SIGNIFICANCE: The ECD resulting from the Na(+) concentration gradient within the canal of sweat glands is thought to be the source of the SSR from the negative pole on the palm to the positive pole on the dorsum. 相似文献
34.
Yuichi Yamada Teruhiko Kido Masao Ishizaki Ryumon Honda Ikiko Tsuritani Haruki Yamaya Kôji Nogawa 《International archives of occupational and environmental health》1988,60(1):7-14
Summary Forty-nine out of 54 male workers engaged in the production of an epoxy compound, t-methyl-3-phenylglycidate, showed skin symptoms in varing degrees that may be due to the skin-irritative effect of the compound. The exposed workers were also shown to have subjective symptoms which may be related to the irritative property of the compound on surface tissue. Laboratory examinations on the blood obtained from the exposed workers showed significantly higher values of leukocyte concentration as compared with the non-exposed controls. This was chiefly caused by the increase of neutrophilic granulocytes and T-cell lymphocytes. Serum IgA levels of the exposed workers were shown to be significantly lower than those of the control group. Hemoglobin concentration, hematocrit value and red cell count of the exposed workers remained at the same level as those of the control subjects. Liver or kidney damage was not found in biochemical analyses on the sera of exposed workers. 相似文献
35.
36.
T Yamada T Saito Y Matsue Y Honda T Fuchigami M Fujii M Ross 《Electroencephalography and clinical neurophysiology》1992,84(6):492-498
Using a conditioning-test paradigm, we studied the recovery function of tibial nerve somatosensory evoked potentials (SEPs) conditioned by preceding peroneal nerve stimulation. The inter-stimulus intervals (ISIs) ranged from 0 to 400 msec, where 0 msec indicated simultaneous arrival of tibial and peroneal nerve volleys at the L1 spine. The recovery curve was W-shaped, showing two peaks of SEP suppression, maximum at 6 msec ISI (1st phase) and 50-75 ISI msec (2nd phase). In the 1st phase suppression, we found distinct differences in wave forms between 0-2 msec ISI and 4-6 msec ISI. At 0-2 msec ISI, P40-N50-P60 amplitude decreased and latencies shortened, while P31 and N35 were unchanged. At 4-6 msec ISI, all peaks, possibly excluding P31, were markedly depressed. We attribute the former change to an "occlusive effect" and the latter to an "inhibitory effect," each mediated via a central synaptic network between the two nerves. The attenuation of the 2nd but not the 1st phase suppression by peroneal nerve block distal to the stimulating electrodes provided evidence that the 2nd phase suppression resulted primarily from interfering afferent signals generated by peroneal nerve peripheral receptors, activated by foot movement. 相似文献
37.
Y Honda M Kuriyama I Higuchi J Fujiyama H Yoshida M Osame 《Journal of the neurological sciences》1992,108(2):189-195
We investigated the pathological and biochemical changes of skeletal muscle in rats with lysosomal acid lipase deficiency, which is an animal counterpart of human Wolman's disease. In the affected rats, the acid lipase activity for three different substrates, 4-methylumbelliferyl-oleate (18.9% of the normal control level), [14C]cholesteryl oleate (23.5%), and [14C]triolein (26.9%), was similarly decreased in the lysosomal fraction of skeletal muscle which was obtained by differential centrifugation. Histochemical studies showed that acid phosphatase activity was high in the endomysium and perimysium and in some muscle fibers. Some fibers showed vacuolar degeneration resembling "rimmed vacuoles". Ultrastructural studies demonstrated many membrane-bound lipid droplets in the muscle fibers, especially in the subsarcolemmal space, indicating that a low density lipoprotein (LDL) uptake pathway apparently existed in the muscle cells. However, such lipid accumulation was much greater in the interstitial cells and the endothelial cells. This distribution also suggests that LDL/cholesterol is supplied to muscle cells predominantly through endothelial cells. 相似文献
38.
Key words intractable pain - celiac plexus neurolysis - ultrasonography 相似文献
39.
T. Tsuji R. M. Alborno M. Ehara T. Honda T. Miwatani 《European journal of epidemiology》1989,5(2):199-201
IgA protease produced by various strains of Haemophilus infuenzae can digest serum IgA and yield its fragments which can react with anti-IgA serum. We assayed IgA protease activity by detecting the digests of IgA by SDS-PAGE and immunoblotting. The digests were separated with SDS-PAGE, transferrend to nitrocellulose membranes and detected with anti- ( chain of human IgA, its Fab and its Fc) immunoglobulin conjugated peroxidases.Using this method, we can determine which type of IgA protease is produced by various of H. infuenzae strains. All the 20 strains isolated from respiratory tracts produced IgA protease. 相似文献
40.
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease 总被引:1,自引:0,他引:1
Castellani RJ Honda K Zhu X Cash AD Nunomura A Perry G Smith MA 《Ageing research reviews》2004,3(3):319-326
Metal-catalyzed hydroxyl radicals are potent mediators of cellular injury, affecting every category of macromolecule, and are central to the oxidative injury hypothesis of Alzheimer disease (AD) pathogenesis. Studies on redox-competent copper and iron indicate that redox activity in AD resides exclusively within the neuronal cytosol and that chelation with deferoxamine, DTPA, or, more recently, iodochlorhydroxyquin, removes this activity. We have also found that while proteins that accumulate in AD possess metal-binding sites, metal-associated cellular redox activity is primarily dependent on metals associated with nucleic acid, specifically cytoplasmic RNA. These findings indicate aberrations in iron homeostasis that, we suspect, arise primarily from heme, since heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in AD, and mitochondria, since mitochondria turnover, mitochondrial DNA, and cytochrome C oxidative activity are all increased in AD. These findings, as well as studies demonstrating a reduction in microtubule density in AD neurons, suggest that mitochondrial dysfunction, acting in concert with cytoskeletal pathology, serves to increase redox-active heavy metals and initiates a cascade of abnormal events culminating in AD pathology. 相似文献